公开(公告)号：US09987237B2

公开(公告)日：2018-06-05

申请号：US14833210

申请日：2015-08-24

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli ,  Daniel Anthony Dickman

IPC: C07D487/04 ,  A61K31/4188 ,  A61P35/00 ,  A61K31/045 ,  A61K31/05 ,  A61K45/06 ,  A61K31/165 ,  A61K47/48 ,  A61K31/415 ,  A61K31/4015 ,  A61K31/325 ,  A61N5/10 ,  C07C271/22 ,  C07D231/12 ,  C07D207/26

CPC classification number: A61K31/045 ,  A61K31/05 ,  A61K31/165 ,  A61K31/325 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K45/06 ,  A61K47/54 ,  A61K47/55 ,  A61N5/10 ,  C07B2200/07 ,  C07C271/22 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04 ,  A61K2300/00

Abstract: The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

公开(公告)号：US20200170961A1

公开(公告)日：2020-06-04

申请号：US16675605

申请日：2019-11-06

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli ,  Daniel Anthony Dickman

IPC: A61K31/045 ,  A61K47/54 ,  A61K47/55 ,  A61N5/10 ,  A61K31/4015 ,  A61K31/4188 ,  A61K31/415 ,  A61K31/325 ,  A61K31/165 ,  A61K45/06 ,  A61K31/05 ,  C07D207/26 ,  C07D487/04 ,  C07D231/12 ,  C07C271/22

Abstract: The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

公开(公告)号：US20180280317A1

公开(公告)日：2018-10-04

申请号：US15997300

申请日：2018-06-04

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli ,  Daniel Anthony Dickman

IPC: A61K31/045 ,  A61K47/54 ,  A61K31/05 ,  C07D207/26 ,  C07D487/04 ,  C07D231/12 ,  C07C271/22 ,  A61N5/10 ,  A61K31/4015 ,  A61K47/55 ,  A61K45/06 ,  A61K31/165 ,  A61K31/415 ,  A61K31/4188 ,  A61K31/325

Abstract: The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

公开(公告)号：US20150359754A1

公开(公告)日：2015-12-17

申请号：US14833210

申请日：2015-08-24

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas CHEN ,  Daniel Levin ,  Satish Pupalli ,  Daniel Anthony Dickman

IPC: A61K31/045 ,  A61N5/10 ,  A61K47/48 ,  A61K45/06 ,  A61K31/325

CPC classification number: A61K31/045 ,  A61K31/05 ,  A61K31/165 ,  A61K31/325 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K45/06 ,  A61K47/54 ,  A61K47/55 ,  A61N5/10 ,  C07B2200/07 ,  C07C271/22 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04 ,  A61K2300/00

Abstract: The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

Abstract translation: 本发明提供了治疗诸如癌症的疾病的方法，包括向患者施用治疗有效量的单萜烯或倍半萜烯（或其衍生物）的异构体或类似物，例如异环戊醇。 本发明还提供了治疗疾病的方法，其包括向患者施用治疗有效量的单萜或倍半萜的异构体或类似物的衍生物，例如异哌环醇氨基甲酸酯的步骤。 衍生物可以是与治疗剂如化学治疗剂缀合的异环戊醇。 给药途径可以变化，包括吸入，鼻内，口服，透皮，静脉内，皮下或肌内注射。