公开(公告)号：US12215338B2

公开(公告)日：2025-02-04

申请号：US17053733

申请日：2019-05-08

Applicant: Neuracle Science Co., Ltd. ,  Neuracle Genetics

Inventor： Jong-Mook Kim ,  Dong Sik Kim ,  Juwon Shim ,  Soon-gu Kwon

IPC: A61K48/00 ,  C07K16/24 ,  C12N15/86 ,  A61K39/00

Abstract: The present disclosure provides adeno-associated vims (AAV) vectors and uses thereof. In certain embodiments, the AAV vectors comprise a nucleic acid that encodes an antagonist against a family with sequence similarity 19, member A5 (FAM19A5) protein, e.g., anti-FAM19A5 antibody, e.g., anti-FAM19A5 scFv.

公开(公告)号：US12247070B2

公开(公告)日：2025-03-11

申请号：US17418681

申请日：2019-12-26

Applicant: NEURACLE SCIENCE CO., LTD.

Inventor： Bongcheol Kim ,  Dong Sik Kim ,  Jae-Keun Lee ,  Juwon Shim

IPC: C07K16/24 ,  A61P9/10 ,  A61K39/00

Abstract: The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to treat an atherosclerosis in a subject in need thereof.

公开(公告)号：US11746149B2

公开(公告)日：2023-09-05

申请号：US16626630

申请日：2018-06-27

Applicant: Neuracle Science Co., Ltd.

Inventor： Bongcheol Kim ,  Dong Sik Kim ,  Soon-gu Kwon

IPC: A61K39/395 ,  A61K39/00 ,  C07K16/24

CPC classification number: C07K16/24 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76

Abstract: The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to treat a glaucoma in a subject in need thereof.

公开(公告)号：US11634484B2

公开(公告)日：2023-04-25

申请号：US17050056

申请日：2019-04-24

Applicant: Neuracle Science Co., Ltd.

Inventor： Bongcheol Kim ,  Dong Sik Kim ,  Soon-Gu Kwon

IPC: C07K16/24 ,  A61P25/02 ,  A61K45/06

Abstract: The present disclosure provides a method for the treatment of a neuropathic pain including a central neuropathic pain or a peripheral neuropathic pain in a subject comprising the administration of antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. The present disclosure also provides methods for treating a neuropathic pain including a symptom of neuropathic pain, and/or an underlining cause of a neuropathic pain, by administering an antibody that specifically binds to human FAM19A5. In a specific aspect, the method comprises administering antibodies specifically bind to human FAM19A5, e.g., binds to soluble human FAM19A5 with a KD of 10 nM or less, or binds to membrane bound human FAM19A5 with a KD of 10 nM or less, or both, as measured by a method known in the art, e.g., ELISA.

公开(公告)号：US11618783B2

公开(公告)日：2023-04-04

申请号：US16626624

申请日：2018-06-27

Applicant: Neuracle Science Co., Ltd.

Inventor： Bongcheol Kim ,  Jae-Keun Lee ,  Dong Sik Kim ,  Junho Chung ,  Junyeong Jin

IPC: C07K16/00 ,  A61K39/395 ,  C07K16/24 ,  A61P35/00 ,  G01N33/50 ,  G01N33/574 ,  A61K39/00

Abstract: The present disclosure provides antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. Also provided herein are methods for treating fibrosis or cancer using the anti-FAM19A5 antibodies.

公开(公告)号：US11155613B2

公开(公告)日：2021-10-26

申请号：US16626621

申请日：2018-06-27

Applicant: Neuracle Science Co., Ltd.

Inventor： Bongcheol Kim ,  Jae-Keun Lee ,  Dong Sik Kim

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/24 ,  G01N33/68

Abstract: The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to treat or to diagnose a fibrosis and/or a fibrosis-associated disease in a subject in need thereof.

公开(公告)号：US12077579B2

公开(公告)日：2024-09-03

申请号：US17475214

申请日：2021-09-14

Applicant: Neuracle Science Co., Ltd.

Inventor： Bongcheol Kim ,  Jae-Keun Lee ,  Dong Sik Kim

IPC: G01N33/53 ,  C07K16/24 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/24 ,  G01N33/6863 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76

Abstract: The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to treat or to diagnose a fibrosis and/or a fibrosis-associated disease in a subject in need thereof.

公开(公告)号：US11560425B2

公开(公告)日：2023-01-24

申请号：US16626625

申请日：2018-06-27

Applicant: Neuracle Science Co., Ltd.

Inventor： Bongcheol Kim ,  Eun Bee Cho ,  Dong Sik Kim ,  Jae-Keun Lee ,  Soon-gu Kwon ,  Jae Young Seong ,  Juwon Shim ,  Tae Woo Kim ,  Shin-hyuk Kang

IPC: C07K16/24 ,  C07K16/30 ,  A61P35/00 ,  A61K45/06 ,  A61K39/00 ,  C07K16/28 ,  A61K39/395

Abstract: The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to promote a blood vessel normalization and treat a disease (e.g., cancer) in a subject in need thereof, e.g., by promoting a blood vessel normalization.