公开(公告)号：US20130303499A1

公开(公告)日：2013-11-14

申请号：US13946794

申请日：2013-07-19

Applicant: Nicox S.A.

Inventor： Francesca BENEDINI ,  Annalisa BONFANTI ,  Valerio CHIROLI ,  Rebecca STEELE ,  Ennio ONGINI ,  Stefano BIONDI

IPC: C07J71/00

CPC classification number: C07J71/0031 ,  C07J41/005

Abstract: The invention relates to nitrooxy derivatives of fluocinolone acetonide, triamcinolone acetonide, betamethasone and beclomethasone, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for treating diabetic macular edema, diabetic retinopathy, macular degeneration, age-related macular degeneration and other diseases of retina and macula lutea.

Abstract translation: 本发明涉及氟轻松，丙酸钠，倍他米松和倍氯米松的硝基氧基衍生物，其制备方法，含有这些化合物的药物组合物，以及使用这些化合物和组合物治疗糖尿病性黄斑水肿，糖尿病性视网膜病变，黄斑变性， 黄斑变性等视网膜黄斑病变。

公开(公告)号：US20140288142A1

公开(公告)日：2014-09-25

申请号：US14300049

申请日：2014-06-09

Applicant: NICOX S.A.

Inventor： Nicoletta ALMIRANTE ,  Stefano BIONDI ,  Ennio ONGINI ,  Laura STORONI ,  Alessia NICOTRA

IPC: C07C229/20 ,  A61K31/27 ,  A61K45/06 ,  C07C229/24 ,  A61K31/265 ,  C07D207/16 ,  A61K31/40 ,  A61K31/223 ,  C07D209/52 ,  A61K31/403 ,  C07C271/22 ,  A61K31/225

CPC classification number: C07C229/20 ,  A61K31/223 ,  A61K31/225 ,  A61K31/265 ,  A61K31/27 ,  A61K31/40 ,  A61K31/403 ,  A61K45/06 ,  C07C203/02 ,  C07C229/08 ,  C07C229/22 ,  C07C229/24 ,  C07C229/26 ,  C07C229/36 ,  C07C237/08 ,  C07C271/22 ,  C07C279/14 ,  C07C291/02 ,  C07C323/58 ,  C07D207/16 ,  C07D209/52

Abstract: The invention relates to nitric oxide donor compounds and their use for treating cardiovascular diseases, inflammation, pain, fever, gastrointestinal disorders, ophthalmic diseases, hepatic disorders, renal diseases, respiratory disorders, immunological diseases, bone metobolisms dysfunctions, central and peripheral nervous system diseases, sexual dysfunctions, infectious diseases, for the inhibition of platelet aggregation and platelet adhesion, for treating pathological conditions resulting from abnormal cell proliferation, vascular diseases. The invention also relates to compositions comprising at least one nitric oxide releasing compounds of the invention and composition comprising at least one nitric oxide releasing compounds according to the invention and at least one 15 therapeutic agent.

Abstract translation: 本发明涉及一氧化氮供体化合物及其用于治疗心血管疾病，炎症，疼痛，发烧，胃肠道疾病，眼科疾病，肝脏疾病，肾脏疾病，呼吸系统疾病，免疫疾病，骨骼甲状腺功能异常，中枢和周围神经系统疾病 ，性功能障碍，感染性疾病，用于抑制血小板聚集和血小板粘附，用于治疗由异常细胞增殖，血管疾​​病引起的病理状况。 本发明还涉及包含至少一种本发明的一氧化一氮释放化合物和包含至少一种根据本发明的一氧化氮释放化合物和至少一种治疗剂的组合物的组合物。