公开(公告)号：US20130303499A1

公开(公告)日：2013-11-14

申请号：US13946794

申请日：2013-07-19

Applicant: Nicox S.A.

Inventor： Francesca BENEDINI ,  Annalisa BONFANTI ,  Valerio CHIROLI ,  Rebecca STEELE ,  Ennio ONGINI ,  Stefano BIONDI

IPC: C07J71/00

CPC classification number: C07J71/0031 ,  C07J41/005

Abstract: The invention relates to nitrooxy derivatives of fluocinolone acetonide, triamcinolone acetonide, betamethasone and beclomethasone, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for treating diabetic macular edema, diabetic retinopathy, macular degeneration, age-related macular degeneration and other diseases of retina and macula lutea.

Abstract translation: 本发明涉及氟轻松，丙酸钠，倍他米松和倍氯米松的硝基氧基衍生物，其制备方法，含有这些化合物的药物组合物，以及使用这些化合物和组合物治疗糖尿病性黄斑水肿，糖尿病性视网膜病变，黄斑变性， 黄斑变性等视网膜黄斑病变。

公开(公告)号：US20140135389A1

公开(公告)日：2014-05-15

申请号：US14161520

申请日：2014-01-22

Applicant: NICOX S.A.

Inventor： Gael RONSIN ,  Laura STORONI ,  Francesca BENEDINI

IPC: C07C203/04 ,  A61K45/06 ,  C07D307/20 ,  A61K31/341 ,  A61K31/21 ,  C07C323/22

CPC classification number: C07C203/04 ,  A61K31/21 ,  A61K31/341 ,  A61K45/06 ,  C07C323/22 ,  C07C2601/16 ,  C07D307/20 ,  A61K2300/00

Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.