公开(公告)号：US20180118677A1

公开(公告)日：2018-05-03

申请号：US15561885

申请日：2016-01-28

Applicant: NICOX S.A.

Inventor： Nicoletta ALMIRANTE ,  Laura STORONI ,  Elena BASTIA ,  Stefania BRAMBILLA ,  Francesco IMPAGNATIELLO

IPC: C07C405/00 ,  A61K31/5575 ,  A61P27/06

CPC classification number: C07C405/0016 ,  A61K31/5575 ,  A61P27/06 ,  C07C2601/08

Abstract: The present invention relates to 15-nitrooxyderivatives of fluprostenol, their use for the treatment of glaucoma and ocular hypertension and formulation containing 15-nitrooxy derivatives of fluprostenol.

公开(公告)号：US20170354634A1

公开(公告)日：2017-12-14

申请号：US15527129

申请日：2015-11-17

Applicant: NICOX S.A.

Inventor： Nicoletta ALMIRANTE ,  Laura STORONI ,  Elena BASTIA ,  Francesco IMPAGNATIELLO

IPC: A61K31/34 ,  A61K31/5575 ,  A61K9/00

CPC classification number: A61K31/34 ,  A61K9/0048 ,  A61K31/164 ,  A61K31/191 ,  A61K31/343 ,  A61K31/5575 ,  A61K2300/00

Abstract: The present invention relates to compositions for treating glaucoma and elevated ocular pressure. The compositions comprise a nitric oxide releasing isomannide derivative and a prostaglandin F2α analog.

公开(公告)号：US20210322413A1

公开(公告)日：2021-10-21

申请号：US17265134

申请日：2019-07-31

Applicant: NICOX S.A.

Inventor： Nicoletta ALMIRANTE ,  Stefania BRAMBILLA ,  Laura STORONI ,  Francesco IMPAGNATIELLO ,  Elena BASTIA

IPC: A61K31/506 ,  A61K31/197 ,  A61K45/06 ,  A61P27/06 ,  A61K31/519 ,  C07D403/14 ,  C07D487/04

Abstract: The invention relates to nitric oxide releasing phosphodiesterase type 5 (PDE5) inhibitors of formula (I) or (Ib) or (II) or a stereoisomer or a pharmaceutically acceptable salt thereof: useful for the treatment of ocular condition associated with elevated intraocular pressure such as ocular hypertension, glaucoma or retinopathies. The invention further relates to 3-[(2S)-2,3-bis(nitrooxy)propoxy]propanoic acid and 6-(nitrooxy)hexanoic acid for use in the treatment of ocular condition associated with elevated intraocular pressure such as ocular hypertension, glaucoma or retinopathies.

公开(公告)号：US20180118676A1

公开(公告)日：2018-05-03

申请号：US15561919

申请日：2016-03-22

Applicant: Nicox S.A.

Inventor： Nicoletta ALMIRANTE ,  Laura STORONI ,  Elena BASTIA ,  Stefania BRAMBILLA ,  Francesco IMPAGNATIELLO

IPC: C07C405/00 ,  A61P27/02 ,  A61P27/06 ,  A61K9/00 ,  A61K31/5575 ,  A61K45/06

CPC classification number: C07C405/00 ,  A61K9/0048 ,  A61K31/5575 ,  A61K45/06 ,  A61P27/02 ,  A61P27/06 ,  C07C2601/08 ,  A61K2300/00

Abstract: The present invention relates to 15-nitrooxyderivatives of latanoprost and 15-nitrooxyderivatives of latanoprost free acid, their use for the treatment of glaucoma and ocular hypertension and formulation containing 15-nitrooxyderivatives of latanoprost and 15-nitrooxyderivatives of latanoprost free acid.

公开(公告)号：US20140288142A1

公开(公告)日：2014-09-25

申请号：US14300049

申请日：2014-06-09

Applicant: NICOX S.A.

Inventor： Nicoletta ALMIRANTE ,  Stefano BIONDI ,  Ennio ONGINI ,  Laura STORONI ,  Alessia NICOTRA

IPC: C07C229/20 ,  A61K31/27 ,  A61K45/06 ,  C07C229/24 ,  A61K31/265 ,  C07D207/16 ,  A61K31/40 ,  A61K31/223 ,  C07D209/52 ,  A61K31/403 ,  C07C271/22 ,  A61K31/225

CPC classification number: C07C229/20 ,  A61K31/223 ,  A61K31/225 ,  A61K31/265 ,  A61K31/27 ,  A61K31/40 ,  A61K31/403 ,  A61K45/06 ,  C07C203/02 ,  C07C229/08 ,  C07C229/22 ,  C07C229/24 ,  C07C229/26 ,  C07C229/36 ,  C07C237/08 ,  C07C271/22 ,  C07C279/14 ,  C07C291/02 ,  C07C323/58 ,  C07D207/16 ,  C07D209/52

Abstract: The invention relates to nitric oxide donor compounds and their use for treating cardiovascular diseases, inflammation, pain, fever, gastrointestinal disorders, ophthalmic diseases, hepatic disorders, renal diseases, respiratory disorders, immunological diseases, bone metobolisms dysfunctions, central and peripheral nervous system diseases, sexual dysfunctions, infectious diseases, for the inhibition of platelet aggregation and platelet adhesion, for treating pathological conditions resulting from abnormal cell proliferation, vascular diseases. The invention also relates to compositions comprising at least one nitric oxide releasing compounds of the invention and composition comprising at least one nitric oxide releasing compounds according to the invention and at least one 15 therapeutic agent.

Abstract translation: 本发明涉及一氧化氮供体化合物及其用于治疗心血管疾病，炎症，疼痛，发烧，胃肠道疾病，眼科疾病，肝脏疾病，肾脏疾病，呼吸系统疾病，免疫疾病，骨骼甲状腺功能异常，中枢和周围神经系统疾病 ，性功能障碍，感染性疾病，用于抑制血小板聚集和血小板粘附，用于治疗由异常细胞增殖，血管疾​​病引起的病理状况。 本发明还涉及包含至少一种本发明的一氧化一氮释放化合物和包含至少一种根据本发明的一氧化氮释放化合物和至少一种治疗剂的组合物的组合物。

公开(公告)号：US20140135389A1

公开(公告)日：2014-05-15

申请号：US14161520

申请日：2014-01-22

Applicant: NICOX S.A.

Inventor： Gael RONSIN ,  Laura STORONI ,  Francesca BENEDINI

IPC: C07C203/04 ,  A61K45/06 ,  C07D307/20 ,  A61K31/341 ,  A61K31/21 ,  C07C323/22

CPC classification number: C07C203/04 ,  A61K31/21 ,  A61K31/341 ,  A61K45/06 ,  C07C323/22 ,  C07C2601/16 ,  C07D307/20 ,  A61K2300/00

Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.