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公开(公告)号:US20200009273A1
公开(公告)日:2020-01-09
申请号:US16491046
申请日:2018-03-05
Inventor: Masato KIRIU , Hiroaki ICHIKAWA , Yuki OKUMURA , Hiroshi TANAKA
IPC: A61K51/04 , C07B59/00 , C07C309/77 , C07C41/22 , C07C43/174 , C07D401/14 , C07D471/04
Abstract: There is provided a labeling precursor compound represented by the general formula (2): wherein S represents a substrate, L represents a straight alkyl group having 1 to 6 carbon atoms which may contain an ether group, R1 and R2 each independently represent a straight or branched alkyl group having 1 to 30 carbon atoms, or a substituted or unsubstituted monocyclic or condensed polycyclic aryl group, R3 each independently represent an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms, and p represents an integer of 0 to 4.
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公开(公告)号:US20190169169A1
公开(公告)日:2019-06-06
申请号:US16211434
申请日:2018-12-06
Inventor: Akihiro IZAWA , Kei AKAMA , Yuki OKUMURA , Yurie FUKUI , Nobuya KOBASHI , Tsutomu ABE , Yoshihiro DOI , Miho IKENAGA , Hideo SAJI , Hiroyuki KIMURA , Mitsuhide NARUSE
IPC: C07D401/14 , A61K51/04 , A61K51/00 , A61K31/4439
CPC classification number: C07D401/14 , A61K31/4439 , A61K51/00 , A61K51/0455 , C07B2200/05
Abstract: Provided is a medicament comprising the compound represented by the following general formula (1) or a salt thereof: In the formula, R1, R2, R3, R4, R5, X1, X2, and X3 are defined. Methods for producing various radioactive compounds are also provided.
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公开(公告)号:US20170158668A1
公开(公告)日:2017-06-08
申请号:US15321972
申请日:2015-06-25
Inventor: Akihiro IZAWA , Kei AKAMA , Yuki OKUMURA , Yurie FUKUI , Nobuya KOBASHI , Tsutomu ABE , Yoshihiro DOI , Miho IKENAGA , Hideo SAJI , Hiroyuki KIMURA , Mitsuhide NARUSE
IPC: C07D401/14 , A61K51/04
CPC classification number: C07D401/14 , A61K31/4439 , A61K51/00 , A61K51/0455 , C07B2200/05
Abstract: Provided is a compound represented by general formula (1) or a salt thereof as well as a medicine containing the compound or the salt. In the formula, R1, R2, R3, R4, R5, X1, X2, and X3 are defined.
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公开(公告)号:US20230248854A1
公开(公告)日:2023-08-10
申请号:US17769657
申请日:2020-10-16
Applicant: NIHON MEDI-PHYSICS CO., LTD.
Inventor: Akihiro IZAWA , Yu OGAWA , Hiroaki ICHIKAWA , Minoru KAWATANI , Hideaki TAKEMORI , Yuki OKUMURA
IPC: A61K51/10
CPC classification number: A61K51/10
Abstract: The production method of a radioactive metal-labeled antibody of the present invention includes a step of conducting a click reaction of a radioactive metal complex and an antibody site-specifically modified with a peptide to produce a radioactive metal-labeled antibody. The click reaction is performed between a first atomic group of the radioactive metal complex and a second atomic group directly or indirectly linked to the peptide. The second atomic group is an atomic group containing an azide group, or an atomic group containing trans-cyclooctene.
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公开(公告)号:US20210060186A1
公开(公告)日:2021-03-04
申请号:US16958427
申请日:2018-12-20
Inventor: Akihiro IZAWA , Yuki OKUMURA , Yurie FUKUI , Hiroaki ICHIKAWA , Yoshifumi MAYA , Miho IKENAGA , Hiroyuki OKUDAIRA , Yoshihiro DOI , Mitsuhide NARUSE
IPC: A61K51/04 , C07B59/00 , C07D401/14
Abstract: Provided are a compound represented by the following formula (1): wherein X1 represents a hydrogen atom or a halogen atom, X2 represents a fluorine atom or a nitrile group, and X3 represents a radioactive halogen atom, or a salt thereof, and a medicament including the same.
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