公开(公告)号：US20190083628A1

公开(公告)日：2019-03-21

申请号：US16079290

申请日：2017-02-21

Applicant: NIPRO CORPORATION ,  ZENSEI PHARMACEUTICAL INDUSTRIES CO., LTD.

Inventor： Tomohiro HAYASHIDA ,  Yohei HOASHI ,  Shin IJITSU ,  Yoshio NAKANO ,  Junji YAMAZAKI ,  Katsuhisa INOUE ,  Atsushi AIZAWA

IPC: A61K47/38 ,  A61K9/20 ,  A61K47/32 ,  A61K9/00 ,  A61K31/136

Abstract: Provided are pharmaceutical composition particles which are capable of achieving both of masking of an unpalatable taste and improvement in dissolution properties; an orally disintegrating tablet including the pharmaceutical composition particles; and a method for manufacturing the pharmaceutical composition particles. Each of the pharmaceutical composition particles includes: a core particle containing a water-soluble gelling swelling substance; an intermediate layer containing a drug and coating an outside of the core particle; and an outer layer containing a water-insoluble substance and coating an outside of the intermediate layer. In addition, the orally disintegrating tablet includes the above-described pharmaceutical composition particles.

公开(公告)号：US20200214985A1

公开(公告)日：2020-07-09

申请号：US16641014

申请日：2018-08-20

Applicant: NIPRO CORPORATION ,  ZENSEI PHARMACEUTICAL INDUSTRIES CO.,LTD.

Inventor： Tomohiro HAYASHIDA ,  Yohei HOASHI ,  Shin IJITSU ,  Yoshio NAKANO ,  Junji YAMAZAKI ,  Katsuhisa INOUE ,  Atsushi AIZAWA

IPC: A61K9/28 ,  A61K9/48

Abstract: Pharmaceutical composition particle capable of masking an unpalatable taste and improvement in dissolution properties, an orally disintegrating tablet containing the pharmaceutical composition particle, and a method for manufacturing a pharmaceutical composition particle. The pharmaceutical composition particle includes a core particle containing a drug and a water-soluble gelling swelling substance; and an outer layer which contains a water-insoluble substance and constitutes a coating provided on the outer side of the core particle. The method for manufacturing includes: pulverizing a water-soluble gelling swelling substance to have an average particle diameter of 15 μm or less; a core particle manufacturing step of mixing the water-soluble gelling swelling substance pulverized and a drug to manufacture a core particle; and an outer layer formation step of coating the core particle with a water-insoluble substance on the outer side of the core particle.

公开(公告)号：US20220218617A1

公开(公告)日：2022-07-14

申请号：US17605860

申请日：2020-04-21

Applicant: NIPRO CORPORATION

Inventor： Yoshio NAKANO ,  Tomohiro HAYASHIDA ,  Yohei HOASHI ,  Keisuke EDAMURA ,  Yuki ICHIKAWA

IPC: A61K9/28 ,  A61K31/352 ,  A61K9/20 ,  A61K31/137

Abstract: Problem to be Solved
Provided is a method for manufacturing a pharmaceutical preparation, which safely and simply enables uniformization of contents of a small amount of a drug.
[Solution]
The method for manufacturing the pharmaceutical preparation includes: using a liquid for dispensing, the liquid containing a drug; and a first application step of applying the drug to a surface of a tablet or a capsule by a dispensing method. In addition, a pharmaceutical preparation according to the present invention includes: a base; and a drug which is applied to a surface of the base by a dispensing method, and the base is a tablet or a capsule.

公开(公告)号：US20190054029A1

公开(公告)日：2019-02-21

申请号：US16079288

申请日：2017-02-21

Applicant: NIPRO CORPORATION ,  ZENSEI PHARMACEUTICAL INDUSTRIES CO., LTD.

Inventor： Tomohiro HAYASHIDA ,  Yohei HOASHI ,  Shin IJITSU ,  Yoshio NAKANO ,  Junji YAMAZAKI ,  Katsuhisa INOUE ,  Atsushi AIZAWA

IPC: A61K9/20 ,  A61K9/00 ,  A61K31/137 ,  A61K47/32 ,  A61K47/38

Abstract: Provided are pharmaceutical composition particles which are capable of achieving both of masking of an unpalatable taste and improvement in dissolution properties; an orally disintegrating tablet including the pharmaceutical composition particles; and a method for manufacturing the pharmaceutical composition particles. Each of the pharmaceutical composition particles includes: a drug-containing core particle; an intermediate layer containing a gelling swelling substance and coating an outside of the core particle; and an outermost layer containing a water-insoluble substance and coating an outside of the intermediate layer. In addition, the method for manufacturing the pharmaceutical composition particles includes: a pulverization step of pulverizing the gelling swelling substance so as to have an average particle diameter of 15 μm or less; a suspension step of obtaining a suspension by suspending the gelling swelling substance pulverized at the pulverization step in an organic solvent; an intermediate layer formation step of forming an intermediate layer on an outside of a core particle by spraying the suspension obtained at the suspension step onto the core particle containing a drug; and an outer layer formation step of forming an outer layer by coating an outside of the intermediate layer with a water-insoluble substance.

公开(公告)号：US20170196816A1

公开(公告)日：2017-07-13

申请号：US15315449

申请日：2015-06-02

Applicant: NIPRO CORPORATION

Inventor： Yohei HOASHI ,  Shotaro IKUTA

IPC: A61K9/20 ,  A61K9/28 ,  A61K31/47 ,  A61J3/00

CPC classification number: A61K9/2072 ,  A61J3/005 ,  A61J3/007 ,  A61K9/2813 ,  A61K9/2866 ,  A61K9/2886 ,  A61K9/2893 ,  A61K31/47 ,  A61K31/505 ,  A61K31/551 ,  A61K45/00

Abstract: A laser-printable tablet has: a tablet containing an optically unstable drug, a first cover layer that covers the tablet and contains a first color change-inducing oxide, and a second cover layer that covers the first cover layer and contains a second color change-inducing oxide, the concentration in which the second color change-inducing oxide is contained in the second cover layer being different from the concentration in which the first color change-inducing oxide is contained in the first cover layer.