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1.发明申请公开(公告)号：US20190134260A1
公开(公告)日：2019-05-09
申请号：US16095317
申请日：2017-04-18
Applicant: NIPRO CORPORATION
Inventor： Yusuke Nakamura , Yoshikatsu Sugahara , Kazuhisa Matsuda
Abstract: A sheet-like hemostatic material is provided with: an adhesive layer which serves as an affixing surface to a bleeding site and which is formed from at least poly-γ-glutamic acid (γ-PGA); and a covering layer which is a sheet formed from at least one biodegradable material (covering material) other than γ-PGA, and which serves as an opposite surface to the affixing surface. At least one of the adhesive layer and the covering layer is a single sheet. If the adhesive layer is a single sheet, the adhesive layer should be a sponge-like sheet, and if the adhesive layer is a partial layer, the adhesive layer should be a sponge-like sheet or a nonporous layer. Alternatively, in another sheet-like hemostatic material, a sheet which is formed from at least poly-γ-glutamic acid (γ-PGA) and to which at least one of a saccharide and collagen has been added is provided as the adhesive layer.
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公开(公告)号：US20180015208A1
公开(公告)日：2018-01-18
申请号：US15715210
申请日：2017-09-26
Applicant: Nipro Corporation
Inventor： Yusuke Nakamura , Kazuhisa Matsuda
CPC classification number: A61L31/06 , A61L31/047 , A61L31/14 , A61L31/145 , A61L2300/424 , A61L2400/06
Abstract: Provided is a method for preventing postoperative adhesion of an organ in a wound site using the application of an antiadhesive material thereto. The antiadhesive material contains a poly-γ-glutamic acid having a weight-average molecular weight of 600,000 to 13,000,000, or a kinematic viscosity at 37° C. of 2 cSt to 15 cSt when dissolved in distilled water at a concentration of 0.05% by mass and/or a salt thereof, as an effective ingredient. The antiadhesive material may be in a form such as powder, and therefore, for example, is easy to handle even in relatively localized surgery such as endoscopic surgery and can more reliably prevent adhesion.
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公开(公告)号：US20150209481A1
公开(公告)日：2015-07-30
申请号：US14419260
申请日：2013-07-23
Applicant: Nipro Corporation
Inventor： Yusuke Nakamura , Kazuhisa Matsuda
IPC: A61L31/06
CPC classification number: A61L31/06 , A61L31/047 , A61L31/14 , A61L31/145 , A61L2300/424 , A61L2400/06
Abstract: An antiadhesive material is provided and contains a poly-γ-glutamic acid having a weight-average molecular weight of 600,000 to 13,000,000, or a kinematic viscosity at 37° C. of 2 cSt to 15 cSt when dissolved in distilled water at a concentration of 0.05% by mass and/or a salt thereof, as an effective ingredient. The antiadhesive material may have any form such as powder or gel form, and therefore, for example, is easy to handle even in relatively localized surgery such as endoscopic surgery and can more reliably prevent adhesion.
Abstract translation: 提供了一种防粘附材料，并且当溶于蒸馏水中时，其重量平均分子量为600,000至13,000,000或37℃时的运动粘度为2cSt至15cSt，浓度为 0.05质量％和/或其盐作为有效成分。 抗粘剂材料可以具有粉末或凝胶形式的任何形式，因此例如即使在诸如内窥镜手术的相对局部手术中也容易处理，并且可以更可靠地防止粘附。
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公开(公告)号：US10744234B2
公开(公告)日：2020-08-18
申请号：US15715210
申请日：2017-09-26
Applicant: Nipro Corporation
Inventor： Yusuke Nakamura , Kazuhisa Matsuda
Abstract: Provided is a method for preventing postoperative adhesion of an organ in a wound site using the application of an antiadhesive material thereto. The antiadhesive material contains a poly-γ-glutamic acid having a weight-average molecular weight of 600,000 to 13,000,000, or a kinematic viscosity at 37° C. of 2 cSt to 15 cSt when dissolved in distilled water at a concentration of 0.05% by mass and/or a salt thereof, as an effective ingredient. The antiadhesive material may be in a form such as powder, and therefore, for example, is easy to handle even in relatively localized surgery such as endoscopic surgery and can more reliably prevent adhesion.
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