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    SHEET-LIKE HEMOSTATIC MATERIAL EMPLOYING POLY-GAMMA-GLUTAMIC ACID, AND METHOD OF MANUFACTURING SAME
    1.
    发明申请
    SHEET-LIKE HEMOSTATIC MATERIAL EMPLOYING POLY-GAMMA-GLUTAMIC ACID, AND METHOD OF MANUFACTURING SAME 审中-公开

    公开(公告)号：US20190134260A1

    公开(公告)日：2019-05-09

    申请号：US16095317

    申请日：2017-04-18

    Applicant: NIPRO CORPORATION

    Inventor： Yusuke Nakamura ,  Yoshikatsu Sugahara ,  Kazuhisa Matsuda

    IPC: A61L24/04 ,  A61L24/10 ,  A61L24/00 ,  A61L24/08

    Abstract: A sheet-like hemostatic material is provided with: an adhesive layer which serves as an affixing surface to a bleeding site and which is formed from at least poly-γ-glutamic acid (γ-PGA); and a covering layer which is a sheet formed from at least one biodegradable material (covering material) other than γ-PGA, and which serves as an opposite surface to the affixing surface. At least one of the adhesive layer and the covering layer is a single sheet. If the adhesive layer is a single sheet, the adhesive layer should be a sponge-like sheet, and if the adhesive layer is a partial layer, the adhesive layer should be a sponge-like sheet or a nonporous layer. Alternatively, in another sheet-like hemostatic material, a sheet which is formed from at least poly-γ-glutamic acid (γ-PGA) and to which at least one of a saccharide and collagen has been added is provided as the adhesive layer.

    Antiadhesive Material
    3.
    发明申请
    Antiadhesive Material 审中-公开
    防粘材料

    公开(公告)号：US20150209481A1

    公开(公告)日：2015-07-30

    申请号：US14419260

    申请日：2013-07-23

    Applicant: Nipro Corporation

    Inventor： Yusuke Nakamura ,  Kazuhisa Matsuda

    IPC: A61L31/06

    CPC classification number: A61L31/06 ,  A61L31/047 ,  A61L31/14 ,  A61L31/145 ,  A61L2300/424 ,  A61L2400/06

    Abstract: An antiadhesive material is provided and contains a poly-γ-glutamic acid having a weight-average molecular weight of 600,000 to 13,000,000, or a kinematic viscosity at 37° C. of 2 cSt to 15 cSt when dissolved in distilled water at a concentration of 0.05% by mass and/or a salt thereof, as an effective ingredient. The antiadhesive material may have any form such as powder or gel form, and therefore, for example, is easy to handle even in relatively localized surgery such as endoscopic surgery and can more reliably prevent adhesion.

    Abstract translation: 提供了一种防粘附材料，并且当溶于蒸馏水中时，其重量平均分子量为600,000至13,000,000或37℃时的运动粘度为2cSt至15cSt，浓度为 0.05质量％和/或其盐作为有效成分。 抗粘剂材料可以具有粉末或凝胶形式的任何形式，因此例如即使在诸如内窥镜手术的相对局部手术中也容易处理，并且可以更可靠地防止粘附。

    Method for preventing postoperative adhesion of an organ in a wound site
    4.
    发明授权
    Method for preventing postoperative adhesion of an organ in a wound site 有权

    公开(公告)号：US10744234B2

    公开(公告)日：2020-08-18

    申请号：US15715210

    申请日：2017-09-26

    Applicant: Nipro Corporation

    Inventor： Yusuke Nakamura ,  Kazuhisa Matsuda

    IPC: A61L31/06 ,  A61L31/14 ,  A61L31/04

    Abstract: Provided is a method for preventing postoperative adhesion of an organ in a wound site using the application of an antiadhesive material thereto. The antiadhesive material contains a poly-γ-glutamic acid having a weight-average molecular weight of 600,000 to 13,000,000, or a kinematic viscosity at 37° C. of 2 cSt to 15 cSt when dissolved in distilled water at a concentration of 0.05% by mass and/or a salt thereof, as an effective ingredient. The antiadhesive material may be in a form such as powder, and therefore, for example, is easy to handle even in relatively localized surgery such as endoscopic surgery and can more reliably prevent adhesion.

    Antiadhesive Kit and Method of Adhesion Prevention
    6.
    发明申请
    Antiadhesive Kit and Method of Adhesion Prevention 审中-公开
    防粘套和防粘连方法

    公开(公告)号：US20160121031A1

    公开(公告)日：2016-05-05

    申请号：US14939374

    申请日：2015-11-12

    Applicant: Nipro Corporation

    Inventor： Yukihiro Morinaga ,  Ryosuke Kamimura ,  Kazuhisa Matsuda ,  Akio Shirasu

    IPC: A61L31/14

    CPC classification number: A61L31/148

    Abstract: An adhesion preventive kit and a method of preventing adhesion are provided which have a preventive effect on adhesion in a surrounding part of an edge of an injured or deficient tissue in guided regeneration therapy for an injured tissue. Specifically, the adhesion preventive kit includes: (A) a first membrane of at least two layers having a biodegradable base layer and an adhesion preventive layer provided respectively at outermost surfaces thereof and a second membrane of at least one layer having an adhesion preventive layer provided at an outermost surface thereof; or (B) an adhesion preventive membrane including a biodegradable base layer and an adhesion preventive layer, which membrane has an outermost surface constituted of the adhesion preventive layer and has a tissue sandwiching part.

    Abstract translation: 提供了一种防粘连剂和防止粘合的方法，其对受伤组织的引导再生治疗中对损伤组织或缺损组织的边缘的周围部分的粘附具有预防作用。 具体而言，粘合防止用具包括：（A）具有生物降解性基底层的至少两层的第一膜和分别在其最表面设置的防粘附层，和具有防粘层的至少一层的第二膜， 在其最外表面; 或（B）具有生物降解性基底层和防粘附层的防粘连膜，该膜具有由防粘附层构成的最外表面，并具有组织夹持部。

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