公开(公告)号：US20200025443A1

公开(公告)日：2020-01-23

申请号：US16499482

申请日：2018-04-02

Applicant: NITTO DENKO CORPORATION

Inventor： Chie MATSUMOTO ,  Takao YOSHIKAWA ,  Takuya SHISHIDO ,  Yuji TOYOTA ,  Sachiko SAKAMOTO ,  Yoshimitsu SHIMOMURA ,  Mitsuhiko HORI

IPC: F26B5/04 ,  F26B5/06 ,  A23L3/54 ,  A23L3/44

Abstract: The present invention aims to provide a method and an apparatus for producing a lyophilized body, each of which can achieve energy saving, low cost, and a reduction in processing time and can provide a lyophilized body less damaged by a freezing process and a drying process. The present invention relates to a method for lyophilizing a substance using an electromagnetic wave, and the lyophilization method includes freezing the substance under irradiation of at least an electromagnetic wave and reduced-pressure drying the frozen substance under irradiation of at least an electromagnetic wave.

公开(公告)号：US20240024252A1

公开(公告)日：2024-01-25

申请号：US18247612

申请日：2021-10-01

Applicant: National University Corporation Hokkaido University ,  Nitto Denko Corporation

Inventor： Yusuke SATO ,  Hideyoshi HARASHIMA ,  Kazuki HASHIBA ,  Masamitsu TAGUCHI ,  Sachiko SAKAMOTO ,  Takuya SHISHIDO ,  Ayaka OTSU ,  Yoshiki MAEDA

IPC: A61K9/51 ,  C12N15/113 ,  A61K48/00 ,  C12N15/88

CPC classification number: A61K9/5123 ,  C12N15/113 ,  A61K48/0041 ,  C12N15/88 ,  C12N2320/32 ,  C12N2310/14

Abstract: The present invention addresses the problem of providing lipid nanoparticles which function as gene transfer carriers capable of selective transfer to the liver or spleen. Lipid nanoparticles which contain a pH-sensitive cationic lipid represented by formula (I) [a represents an integer of 3-5; b represents 0 or 1; R1 and R2 each independently represent a group represented by general formula (A) (R11 and R12 each independently represent a linear or branched C2-15 alkyl group; c represents 0 or 1; v represents an integer of 4-12); and X represents a group represented by general formula (B)(d represents an integer of 0-3; and R3 and R4 each independently represent a C1-4 alkyl group or C2-4 alkenyl group, while R3 and R4 may form a 5- to 7-membered non-aromatic heterocycle) or represents a 5- to 7-membered non-aromatic heterocyclic group]. (I) (R1)(R2)C(OH)—(CH2)a—(O—CO)b—X. (A): (R11)(R12)—CH—(CO—O)c—(CH2)v-. (B):—(CH2)d-N(R3)(R4).


(R1)(R2)C(OH)—(CH2)a—(O—CO)b—X  (I)



(R11)(R12)—CH—(CO—O)c—(CH2)v-  (A)



—(CH2)d—N(R3)(R4)  (B)

公开(公告)号：US20140255466A1

公开(公告)日：2014-09-11

申请号：US14202319

申请日：2014-03-10

Applicant: Nitto Denko Corporation

Inventor： Tsuyoshi MUKOBATA ,  Arimichi OKAZAKI ,  Akinori HANATANI ,  Sachiko SAKAMOTO

IPC: A61K47/12 ,  A61K47/10 ,  A61K31/405 ,  A61K9/70 ,  A61K31/421 ,  A61K31/138

CPC classification number: A61K47/12 ,  A61K9/0014 ,  A61K9/7038 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7084 ,  A61K31/138 ,  A61K31/405 ,  A61K31/421 ,  A61K47/10

Abstract: The present invention relates to a composition for enhancing transdermal absorption of a drug, containing a polyvalent alcohol having 3 to 8 carbon atoms, an organic acid having 2 to 20 carbon atoms, and a higher alcohol having 12 to 20 carbon atoms, and a patch preparation containing a support and a drug-containing adhesive layer containing the composition on one surface of the support.

Abstract translation: 本发明涉及含有碳原子数3〜8的多元醇，碳原子数2〜20的有机酸和碳原子数为12〜20的高级醇的药物的透皮吸收用组合物和贴剂 在载体的一个表面上含有载体和含有该组合物的药物粘合剂层的制剂。

公开(公告)号：US20130084325A1

公开(公告)日：2013-04-04

申请号：US13630945

申请日：2012-09-28

Applicant: Nitto Denko Corporation

Inventor： Sachiko SAKAMOTO ,  Akinori HANATANI ,  Arimichi OKAZAKI ,  Tsuyoshi MUKOBATA

IPC: B32B38/00 ,  A61K31/415 ,  A61K31/343 ,  A61K31/196 ,  A61K9/70 ,  A61K31/554

CPC classification number: A61K9/7053 ,  A61K9/7061

Abstract: The invention provides a method of manufacturing a patch preparation comprising (a) pouring a composition for forming an adhesive layer into a container having a concave part with a shape corresponding to a patch preparation to be manufactured, wherein the composition contains a drug, an adhesive polymer, and an organic solvent; (b) removing the organic solvent from the composition through drying to form a drug-containing adhesive layer in the concave part; and (c) laminating a support on the drug-containing adhesive layer to provide the patch preparation comprising a support and the drug-containing adhesive layer formed on one surface of the support.

Abstract translation: 本发明提供了一种制造贴剂的方法，其包括（a）将用于形成粘合剂层的组合物倒入具有与要制造的贴片制剂相对应的形状的凹部的容器中，其中所述组合物含有药物，粘合剂 聚合物和有机溶剂; （b）通过干燥从组合物中除去有机溶剂，以在凹部中形成含药粘合剂层; 和（c）将载体层压在含药物粘合剂层上以提供包含载体的贴片制剂和形成在载体的一个表面上的含药物粘合剂层。