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公开(公告)号：US20240024252A1
公开(公告)日：2024-01-25
申请号：US18247612
申请日：2021-10-01
Inventor： Yusuke SATO , Hideyoshi HARASHIMA , Kazuki HASHIBA , Masamitsu TAGUCHI , Sachiko SAKAMOTO , Takuya SHISHIDO , Ayaka OTSU , Yoshiki MAEDA
IPC: A61K9/51 , C12N15/113 , A61K48/00 , C12N15/88
CPC classification number: A61K9/5123 , C12N15/113 , A61K48/0041 , C12N15/88 , C12N2320/32 , C12N2310/14
Abstract: The present invention addresses the problem of providing lipid nanoparticles which function as gene transfer carriers capable of selective transfer to the liver or spleen. Lipid nanoparticles which contain a pH-sensitive cationic lipid represented by formula (I) [a represents an integer of 3-5; b represents 0 or 1; R1 and R2 each independently represent a group represented by general formula (A) (R11 and R12 each independently represent a linear or branched C2-15 alkyl group; c represents 0 or 1; v represents an integer of 4-12); and X represents a group represented by general formula (B)(d represents an integer of 0-3; and R3 and R4 each independently represent a C1-4 alkyl group or C2-4 alkenyl group, while R3 and R4 may form a 5- to 7-membered non-aromatic heterocycle) or represents a 5- to 7-membered non-aromatic heterocyclic group]. (I) (R1)(R2)C(OH)—(CH2)a—(O—CO)b—X. (A): (R11)(R12)—CH—(CO—O)c—(CH2)v-. (B):—(CH2)d-N(R3)(R4).
(R1)(R2)C(OH)—(CH2)a—(O—CO)b—X (I)
(R11)(R12)—CH—(CO—O)c—(CH2)v- (A)
—(CH2)d—N(R3)(R4) (B)-
公开(公告)号：US20180326041A1
公开(公告)日：2018-11-15
申请号：US15777396
申请日：2016-11-28
Applicant: NITTO DENKO CORPORATION
Inventor： Takuya SHISHIDO , Daisuke ASARI , Eiji KIYOTOH , Kyohei MATSUSHITA , Wenjing LI , Masahiro FUKASAKA , Katsuyuki OKUBO , Mitsuhiko HORI
CPC classification number: A61K39/145 , A61K9/19 , A61K47/183 , A61K47/26 , A61K47/36 , A61K47/38 , A61K2039/5252 , A61K2039/542 , A61K2039/55511 , A61K2039/70 , A61P31/16
Abstract: The present invention provides a vaccine pharmaceutical composition for oral administration that enables stable storage of an influenza virus antigen and a method for producing the pharmaceutical composition. Provided is a vaccine pharmaceutical composition for oral administration containing an influenza virus antigen, an excipient, a disaccharide, and an amino acid.
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3.发明申请TAPE PREPARATION OF WT1 PEPTIDE CANCER VACCINE FOR TRANSDERMAL ADMINISTRATION 审中-公开WT1肽制剂用于转导管理的胶带制备公开(公告)号：US20140220105A1
公开(公告)日：2014-08-07
申请号：US14166954
申请日：2014-01-29
Applicant: Osaka University , NITTO DENKO CORPORATION
Inventor： Yoshiki MAEDA , Katsuyuki OKUBO , Daisuke ASARI , Arimichi OKAZAKI , Takuya SHISHIDO , Mitsuhiko HORI , Haruo SUGIYAMA
CPC classification number: A61K39/0011 , A61K9/7023 , A61K2039/54
Abstract: The present invention provides a cancer vaccine tape preparation for inducing cellular immunity, comprising: a support, an adhesive layer comprising an adhesive disposed on one side of the support, wherein the adhesive layer carries a combination of: (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a first cellular immunity induction promoter. The tape preparation can provides high efficacy.
Abstract translation: 本发明提供用于诱导细胞免疫的癌症疫苗胶带制剂，其包含：载体，包含设置在载体一侧的粘合剂的粘合剂层，其中所述粘合剂层携带以下组合：（i）WT1肽和/ 或修饰的WT1肽; 和（ii）第一细胞免疫诱导启动子。 胶带制剂可以提供高效率。
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公开(公告)号：US20200025443A1
公开(公告)日：2020-01-23
申请号：US16499482
申请日：2018-04-02
Applicant: NITTO DENKO CORPORATION
Inventor： Chie MATSUMOTO , Takao YOSHIKAWA , Takuya SHISHIDO , Yuji TOYOTA , Sachiko SAKAMOTO , Yoshimitsu SHIMOMURA , Mitsuhiko HORI
Abstract: The present invention aims to provide a method and an apparatus for producing a lyophilized body, each of which can achieve energy saving, low cost, and a reduction in processing time and can provide a lyophilized body less damaged by a freezing process and a drying process. The present invention relates to a method for lyophilizing a substance using an electromagnetic wave, and the lyophilization method includes freezing the substance under irradiation of at least an electromagnetic wave and reduced-pressure drying the frozen substance under irradiation of at least an electromagnetic wave.
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公开(公告)号：US20180147235A1
公开(公告)日：2018-05-31
申请号：US15570851
申请日：2016-04-28
Applicant: NITTO DENKO CORPORATION
Inventor： Kyohei MATSUSHITA , Masahiro FUKASAKA , Takuya SHISHIDO , Daisuke ASARI , Katsuyuki OKUBO , Mitsuhiko HORI
Abstract: The present invention provides an allergy vaccine composition that is useful as a prophylactic or therapeutic agent for an allergic disease and can safely and effectively induce immune tolerance. The vaccine composition is to be administered to a human or animal with an allergic disease for the prevention or treatment of the allergic disease. The vaccine composition contains: an immunomodulator which is a lipopolysaccharide derived from at least one gram-negative bacterium selected from the group consisting of Serratia, Leclercia, Rahnella, Acidicaldus, Acidiphilium, Acidisphaera, Acidocella, Acidomonas, Asaia, Belnapia, Craurococcus, Gluconacetobacter, Gluconobacter, Kozakia, Leahibacter, Muricoccus, Neoasaia, Oleomonas, Paracraurococcus, Rhodopila, Roseococcus, Rubritepida, Saccharibacter, Stella, Swaminathania, Teichococcus, Zavarzinia, Pseudomonas, Achromobacter, Bacillus, Methanoculleus, Methanosarcina, Clostridium, Micrococcus, Flavobacterium, Pantoea, Acetobacter, Zymomonas, Xanthomonas, and Enterobacter, or a salt of the lipopolysaccharide; and at least one allergen.
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Patent Agency Ranking
公开(公告)号：US20140220056A1
公开(公告)日：2014-08-07
申请号：US14166939
申请日：2014-01-29
Applicant: NITTO DENKO CORPORATION
Inventor： Takuya SHISHIDO , Katsuyuki OKUBO , Daisuke ASARI , Arimichi OKAZAKI , Yoshiki MAEDA , Kyohei MATSUSHITA , Wenjing LI , Mitsuhiko HORI , Haruo SUGIYAMA
CPC classification number: A61K39/12 , A61K9/0014 , A61K9/06 , A61K9/7084 , A61K39/0011 , A61K39/39 , A61K47/32 , A61K47/34 , A61K2039/54 , A61K2039/55583
Abstract: Disclosed is a vaccine composition for transdermal administration to induce cellular immunity, comprising an antigen, wherein Th1 cell ratio in a model animal for immunological evaluation that received the composition is 10% or more.
Abstract translation: 公开了一种用于透皮给药以诱导细胞免疫的疫苗组合物，其包含抗原，其中接受组合物的用于免疫评估的模型动物中的Th1细胞比率为10％以上。
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7.发明申请公开(公告)号：US20140220055A1
公开(公告)日：2014-08-07
申请号：US14166932
申请日：2014-01-29
Applicant: OSAKA UNIVERSITY , NITTO DENKO CORPORATION
Inventor： Katsuyuki OKUBO , Yoshiki MAEDA , Arimichi OKAZAKI , Daisuke ASARI , Takuya SHISHIDO , Mitsuhiko HORI , Haruo SUGIYAMA
CPC classification number: A61K9/0014 , A61K38/10 , A61K39/0011 , A61K2039/54
Abstract: The present invention provides a cancer vaccine composition for transdermal administration for inducing cellular immunity, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a cellular immunity induction promoter. The composition efficiently induces cellular immunity against a cancer in a subject.
Abstract translation: 本发明提供一种用于诱导细胞免疫的透皮给药的癌症疫苗组合物，其包含（i）WT1肽和/或修饰的WT1肽; 和（ii）细胞免疫诱导启动子。 组合物有效地诱导受试者中针对癌症的细胞免疫。
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8.发明申请公开(公告)号：US20180326042A1
公开(公告)日：2018-11-15
申请号：US15777441
申请日：2016-11-28
Applicant: NITTO DENKO CORPORATION
Inventor： Eiji KIYOTOH , Mitsuhiko HORI , Daisuke ASARI , Katsuyuki OKUBO , Takuya SHISHIDO , Masahiro FUKASAKA , Kyohei MATSUSHITA
IPC: A61K39/145 , A61K9/19 , A61K47/18 , A61K47/26
CPC classification number: A61K39/145 , A61K9/19 , A61K39/00 , A61K47/18 , A61K47/183 , A61K47/26 , A61K2039/5252 , A61K2039/55511 , A61P31/16
Abstract: The present invention provides a dried influenza vaccine preparation in which the activity of an influenza vaccine can be stably maintained even if the preparation is stored without strict temperature control and which can be stably supplied. The present invention also provides a method for producing the dried influenza vaccine preparation. Provided is a dried influenza vaccine preparation including: an influenza vaccine antigen; a disaccharide; and an-amino acid.
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9.发明申请公开(公告)号：US20170224812A1
公开(公告)日：2017-08-10
申请号：US15501339
申请日：2015-08-04
Applicant: NITTO DENKO CORPORATION
Inventor： Takuya SHISHIDO , Daisuke ASARI , Kyohei MATSUSHITA , Mitsuhiko HORI
IPC: A61K39/39 , A61K31/5377 , A61K31/4709 , A61K31/4545 , A61K31/4465 , A61K31/235
Abstract: The present invention aims to provide a humoral immunity induction-promoting composition and a vaccine pharmaceutical composition which can universally be used for inducing humoral immunity to various antigens and exert a high antibody production inducing effect. The present invention relates to a vaccine pharmaceutical composition for inducing humoral immunity containing an antigen and a humoral immunity induction promoter whose active ingredient is a thrombosis treatment drug.
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10.发明申请公开(公告)号：US20170216430A1
公开(公告)日：2017-08-03
申请号：US15501281
申请日：2015-08-04
Applicant: NITTO DENKO CORPORATION
Inventor： Takuya SHISHIDO , Daisuke ASARI , Kyohei MATSUSHITA , Mitsuhiko HORI
IPC: A61K39/39
CPC classification number: A61K39/39 , A61K45/00 , A61K2039/54 , A61K2039/572 , A61K2039/575
Abstract: The present invention aims to provide a composition for promoting immunity induction and a vaccine pharmaceutical composition which are universally usable for inducing immunity to various antigens and capable of exerting a high immunity inducing effect. The present invention relates to a composition for promoting immunity induction containing at least one nuclear receptor ligand and also relates to a vaccine pharmaceutical composition for inducing immunity containing an antigen and a composition for promoting immunity induction that is at least one nuclear receptor ligand.
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