公开(公告)号：US20140093555A1

公开(公告)日：2014-04-03

申请号：US14039993

申请日：2013-09-27

Applicant: Nitto Denko Corporation

Inventor： Masato NISHIMURA ,  Yoshitaka INOUE ,  Yoshiaki ITO

IPC: A61K9/70 ,  A61K31/4418 ,  A61K31/404

CPC classification number: A61K9/7061 ,  A61K9/7046 ,  A61K31/404 ,  A61K31/4418

Abstract: The present invention provides a patch preparation containing a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a drug, amine oxide, a low-polar liquid component based on an organic compound having an angle of 0-19° as calculated by the formula (I): angle(°)=arctan(inorganic value/organic value)×(180/π) and using an inorganic value and an organic value on an organic conceptual diagram, and an adhesive base, and the adhesive layer has an amine oxide content of 0.1-5 wt % and a low-polar liquid component content of 30-50 wt %.

Abstract translation: 本发明提供了一种在载体的至少一个表面上含有支持体和粘合剂层的贴片制剂，其中粘合剂层含有药物，氧化胺，基于角度为0的有机化合物的低极性液体组分 -19°，角度（°）= arctan（无机值/有机值）×（180 /＆pgr），在有机概念图上使用无机值和有机值，粘合剂 碱，并且粘合剂层的氧化胺含量为0.1-5重量％，低极性液体组分含量为30-50重量％。

公开(公告)号：US20160367494A1

公开(公告)日：2016-12-22

申请号：US15185657

申请日：2016-06-17

Applicant: NITTO DENKO CORPORATION

Inventor： Yu TACHIKAWA ,  Satoshi AMEYAMA ,  Eriko ABE ,  Tetsuya NAKAMURA ,  Naoko URUSHIHARA ,  Jun ISHIKURA ,  Kazuhiro AOYAGI ,  Yoshitaka INOUE ,  Akira YOKOUCHI ,  Tomoya TANAKA

IPC: A61K9/70 ,  A61K31/27 ,  A61K31/428 ,  A61K31/137 ,  A61K47/14

CPC classification number: A61K9/7061 ,  A61K31/137 ,  A61K31/27 ,  A61K31/428 ,  A61K47/14 ,  A61L15/44 ,  A61L15/58 ,  C08L33/06

Abstract: A patch preparation includes a support and a pressure-sensitive adhesive layer formed on one surface of the support. The pressure-sensitive adhesive layer includes: (A) a polymer prepared by copolymerizing monomer components including a hydroxyl group-containing monomer and an alkyl (meth)acrylate monomer; (B) a polymer prepared by copolymerizing monomer components including a methyl methacrylate monomer and a butyl methacrylate monomer; and (C) a basic drug, provided that bisoprolol and a salt thereof are excluded.

Abstract translation: 贴片制剂包括支撑体和形成在支撑体的一个表面上的压敏粘合剂层。 压敏粘合剂层包括：（A）通过使包含含羟基的单体和（甲基）丙烯酸烷基酯单体的单体成分共聚而制备的聚合物; （B）通过使包含甲基丙烯酸甲酯单体和甲基丙烯酸丁酯单体的单体组分共聚制备的聚合物; 和（C）碱性药物，条件是排除比索洛尔及其盐。