公开(公告)号：US10266566B2

公开(公告)日：2019-04-23

申请号：US14904715

申请日：2014-07-15

Applicant: North Carolina State University

Inventor： Stefano Menegatti ,  Benjamin G. Bobay ,  Ruben G. Carbonell

IPC: C07K1/22 ,  C07K7/06 ,  C07K7/08 ,  C07K16/06

Abstract: This invention relates generally to the discovery of novel protease-resistant peptide ligands and uses thereof. Specifically, the present invention provides a protease-resistant peptide with three to twenty amino acids capable of binding a biological and comprising one or more basic amino acid(s) and I or aromatic amino acids, wherein one or more of the amino acids is substituted with a non-naturally occurring amino acid analog.

公开(公告)号：US20160159859A1

公开(公告)日：2016-06-09

申请号：US14904715

申请日：2014-07-15

Applicant: NORTH CAROLINA STATE UNIVERSITY

Inventor： Stefano Menegatti ,  Benjamin G. Bobay ,  Ruben G. Carbonell

IPC: C07K7/06 ,  C07K1/22 ,  C07K16/06

CPC classification number: C07K7/06 ,  C07K1/22 ,  C07K7/08 ,  C07K16/065

Abstract: This invention relates generally to the discovery of novel protease-resistant peptide ligands and uses thereof. Specifically, the present invention provides a protease-resistant peptide with three to twenty amino acids capable of binding a biological and comprising one or more basic amino acid(s) and I or aromatic amino acids, wherein one or more of the amino acids is substituted with a non-naturally occurring amino acid analog.

Abstract translation: 本发明一般涉及新蛋白酶抗性肽配体的发现及其用途。 具体地说，本发明提供一种能够结合生物学并含有一个或多个碱性氨基酸和I或芳族氨基酸的3-20个氨基酸的蛋白酶抗性肽，其中一个或多个氨基酸被取代 与非天然存在的氨基酸类似物。