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1.发明公开公开(公告)号：US20230375539A1
公开(公告)日：2023-11-23
申请号：US18248296
申请日：2021-10-08
Applicant: North Carolina State University
Inventor： Stefano Menegatti , Michael Daniele , Katie Kilgour , Brendan Turner
IPC: G01N33/542 , G01N33/68
CPC classification number: G01N33/542 , G01N33/6854 , G01N2021/6439
Abstract: The present disclosure provides compositions, methods, and systems related to a dual-affinity ratiometric quenching bioassay. In particular, the present disclosure provides novel compositions and methods that combine selective biorecognition and quenching of fluorescence signals for rapid and sensitive quantification of antibodies in complex samples.
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公开(公告)号：US20250020640A1
公开(公告)日：2025-01-16
申请号：US18713047
申请日：2022-11-23
Applicant: North Carolina State University
Inventor： Stefano Menegatti , Michael Daniele , Brendan Turner , Katie Kilgour
IPC: G01N33/542 , G01N33/569 , G01N33/58
Abstract: The present disclosure provides compositions, methods, and systems related to a dual-affinity ratiometric quenching bioassay. In particular, the present disclosure provides novel compositions and methods that combine selective biorecognition and quenching of fluoescence signals for rapid and sensitive quantification of proteins in complex samples.
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公开(公告)号：US09162223B2
公开(公告)日：2015-10-20
申请号：US13724245
申请日：2012-12-21
Applicant: NORTH CAROLINA STATE UNIVERSITY
Inventor： Ruben G. Carbonell , Stefano Menegatti , Amith D. Naik
IPC: B01J39/26 , B01J20/286 , B01D15/38 , B01J20/32
CPC classification number: B01J39/26 , B01D15/3804 , B01J20/286 , B01J20/3251 , B01J20/3272
Abstract: This invention is directed to the production of improved chromatographic resins and method of making and using such resins.
Abstract translation: 本发明涉及改进色谱树脂的制备及其制备和使用方法。
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公开(公告)号：US20230399358A1
公开(公告)日：2023-12-14
申请号：US17766884
申请日：2020-10-08
Applicant: North Carolina State University
Inventor： Stefano Menegatti , Xingqing Xiao , Carol K. Hall , Hannah Reese
Abstract: The present invention provides synthetic peptides comprising an amino acid sequence of any one of SEQ ID NOs: 1-17 or an amino acid sequence having at least 80%, 85%, 90%, or 95% sequence identity to the amino acid sequence of any one of SEQ ID NOs:1-17. Also described herein are solid supports including peptides and methods of using such peptides and solid supports.
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公开(公告)号：US20230133133A1
公开(公告)日：2023-05-04
申请号：US17912211
申请日：2021-03-19
Applicant: NORTH CAROLINA STATE UNIVERSITY
Inventor： Milad Abolhasani , Keshav Raghuvanshi , Cheng Zhu , Mahdi Ramezani , Erik E. Santiso , Stefano Menegatti
Abstract: Aldehyde generation includes providing a first input stream, a second input, and an alkene substrate to a reactor system. The first input stream includes a catalyst, a ligand, and an organic solvent. The second input stream includes a mixture of carbon monoxide (CO) and hydrogen gas (H2). The alkene substrate is in either gaseous form or liquid form, the liquid form of the alkene substrate being provided with the first input stream, the gaseous form of the alkene substrate being provided with the second input stream. The reactor system includes a first reactor and a second reactor, where the second reactor is gas permeable and positioned within the first reactor.
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Patent Agency Ranking
公开(公告)号：US20250092089A1
公开(公告)日：2025-03-20
申请号：US18890289
申请日：2024-09-19
Applicant: North Carolina State University , Merck Sharp and Dohme LLC , EMD Millipore Corporation , Rensselaer Polytechnic Institute
Inventor： Stefano Menegatti , Ruben G. Carbonell , Jacob P. LeBarre , Cristiana Boi , Steven Cramer , Michael Phillips , David Roush
Abstract: The present disclosure provides methods related to the purification of a biologic. In particular, the present disclosure methods for purifying a biologic using a multifunctional chromatography medium comprising porous beads or particles having a defined pore diameter distribution and one or more ligands conjugated to the surface of the pores capable of removing process-related impurities and product-related impurities from a target biologic.
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公开(公告)号：US20250091034A1
公开(公告)日：2025-03-20
申请号：US18890315
申请日：2024-09-19
Applicant: North Carolina State University
Inventor： Stefano Menegatti , Jacob P. LeBarre
IPC: B01J20/283 , B01D15/32 , B01D15/36 , B01D15/38 , B01J20/28 , B01J20/288 , B01J20/292
Abstract: The present disclosure provides materials and methods related to the purification of a biologic. The present disclosure provides materials and methods related to the purification of a biologic. In particular, the present disclosure provides a multifunctional chromatography medium comprising porous beads or particles having a defined pore diameter distribution and one or more ligands conjugated to the surface of the pores capable of removing process-related impurities and product-related impurities from a target biologic.
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公开(公告)号：US20240174712A1
公开(公告)日：2024-05-30
申请号：US18060215
申请日：2022-11-30
Applicant: North Carolina State University
Inventor： Stefano Menegatti , Wenning Chu
IPC: C07K1/32
CPC classification number: C07K1/32
Abstract: The present disclosure provides compositions and methods related to the purification and/or isolation of α-1 antitrypsin (AAT). In particular, the present disclosure provides novel peptide ligands capable of binding recombinantly produced α-1 antitrypsin to facilitate its isolation and/or purification from processing fluid streams for subsequent therapeutic use.
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公开(公告)号：US10266566B2
公开(公告)日：2019-04-23
申请号：US14904715
申请日：2014-07-15
Applicant: North Carolina State University
Inventor： Stefano Menegatti , Benjamin G. Bobay , Ruben G. Carbonell
Abstract: This invention relates generally to the discovery of novel protease-resistant peptide ligands and uses thereof. Specifically, the present invention provides a protease-resistant peptide with three to twenty amino acids capable of binding a biological and comprising one or more basic amino acid(s) and I or aromatic amino acids, wherein one or more of the amino acids is substituted with a non-naturally occurring amino acid analog.
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公开(公告)号：US20160159859A1
公开(公告)日：2016-06-09
申请号：US14904715
申请日：2014-07-15
Applicant: NORTH CAROLINA STATE UNIVERSITY
Inventor： Stefano Menegatti , Benjamin G. Bobay , Ruben G. Carbonell
CPC classification number: C07K7/06 , C07K1/22 , C07K7/08 , C07K16/065
Abstract: This invention relates generally to the discovery of novel protease-resistant peptide ligands and uses thereof. Specifically, the present invention provides a protease-resistant peptide with three to twenty amino acids capable of binding a biological and comprising one or more basic amino acid(s) and I or aromatic amino acids, wherein one or more of the amino acids is substituted with a non-naturally occurring amino acid analog.
Abstract translation: 本发明一般涉及新蛋白酶抗性肽配体的发现及其用途。 具体地说，本发明提供一种能够结合生物学并含有一个或多个碱性氨基酸和I或芳族氨基酸的3-20个氨基酸的蛋白酶抗性肽，其中一个或多个氨基酸被取代 与非天然存在的氨基酸类似物。
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