公开(公告)号：US11530213B2

公开(公告)日：2022-12-20

申请号：US17071311

申请日：2020-10-15

Applicant: NOVARTIS AG

Inventor： Guillaume Barbe ,  Gregory Raymond Bebernitz ,  Sicong Geng ,  Hatice Belgin Gulgeze Efthymiou ,  Lv Liao ,  Fupeng Ma ,  Ruowei Mo ,  David Thomas Parker ,  Yunshan Peng ,  Stefan Peukert ,  Nichola Smith ,  Ken Yamada ,  Kayo Yasoshima

IPC: A61P9/00 ,  A61P9/06 ,  C07D471/04 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/675 ,  A61K45/06 ,  C07F9/6561

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R1, R3-R6, X2 and X3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US10266531B2

公开(公告)日：2019-04-23

申请号：US15788248

申请日：2017-10-19

Applicant: NOVARTIS AG

Inventor： Guillaume Barbe ,  Gregory Raymond Bebernitz ,  Sicong Geng ,  Hatice Belgin Gulgeze Efthymiou ,  Lv Liao ,  Fupeng Ma ,  Ruowei Mo ,  David Thomas Parker ,  Yunshan Peng ,  Stefan Peukert ,  Ken Yamada ,  Kayo Yasoshima

IPC: C07D487/04 ,  C07D471/04 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/675 ,  A61K45/06 ,  C07F9/6561 ,  A61P9/06

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R1, R3-R6, X2 and X3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.