公开(公告)号：US09895389B2

公开(公告)日：2018-02-20

申请号：US15134016

申请日：2016-04-20

Applicant: Novartis AG

Inventor： Gregory Raymond Bebernitz ,  Mark G. Bock ,  Dumbala Srinivas Reddy ,  Atul Kashinath Hajare ,  Vinod Vyavahare ,  Sandeep Bhausaheb Bhosale ,  Suresh Eknath Kurhade ,  Videsh Salunkhe ,  Nadim S. Shaikh ,  Debnath Bhuniya ,  P. Venkata Palle ,  Lili Feng ,  Jessica Liang

IPC: A61K31/7048 ,  A61K31/706 ,  A61K31/7052 ,  C07D405/10 ,  C07D407/10 ,  C07D413/10 ,  C07H7/04

CPC classification number: A61K31/7052 ,  A61K31/7048 ,  A61K31/706 ,  C07D405/10 ,  C07D407/10 ,  C07D413/10 ,  C07H7/04

Abstract: This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.

公开(公告)号：US11530213B2

公开(公告)日：2022-12-20

申请号：US17071311

申请日：2020-10-15

Applicant: NOVARTIS AG

Inventor： Guillaume Barbe ,  Gregory Raymond Bebernitz ,  Sicong Geng ,  Hatice Belgin Gulgeze Efthymiou ,  Lv Liao ,  Fupeng Ma ,  Ruowei Mo ,  David Thomas Parker ,  Yunshan Peng ,  Stefan Peukert ,  Nichola Smith ,  Ken Yamada ,  Kayo Yasoshima

IPC: A61P9/00 ,  A61P9/06 ,  C07D471/04 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/675 ,  A61K45/06 ,  C07F9/6561

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R1, R3-R6, X2 and X3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：USRE49080E1

公开(公告)日：2022-05-24

申请号：US16793734

申请日：2020-02-18

Applicant: Novartis AG

Inventor： Gregory Raymond Bebernitz ,  Mark G. Bock ,  Dumbala Srinivas Reddy ,  Atul Kashinath Hajare ,  Vinod Vyavahare ,  Sandeep Bhausaheb Bhosale ,  Suresh Eknath Kurhade ,  Videsh Salunkhe ,  Nadim S. Shaikh ,  Debnath Bhuniya ,  P. Venkata Palle ,  Lili Feng ,  Jessica Liang

IPC: A61K31/7052 ,  A61K31/7048 ,  A61K31/706 ,  C07D405/10 ,  C07D407/10 ,  C07D413/10 ,  C07H7/04

Abstract: This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.

公开(公告)号：US10266531B2

公开(公告)日：2019-04-23

申请号：US15788248

申请日：2017-10-19

Applicant: NOVARTIS AG

Inventor： Guillaume Barbe ,  Gregory Raymond Bebernitz ,  Sicong Geng ,  Hatice Belgin Gulgeze Efthymiou ,  Lv Liao ,  Fupeng Ma ,  Ruowei Mo ,  David Thomas Parker ,  Yunshan Peng ,  Stefan Peukert ,  Ken Yamada ,  Kayo Yasoshima

IPC: C07D487/04 ,  C07D471/04 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/675 ,  A61K45/06 ,  C07F9/6561 ,  A61P9/06

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R1, R3-R6, X2 and X3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20170042925A1

公开(公告)日：2017-02-16

申请号：US15134016

申请日：2016-04-20

Applicant: NOVARTIS AG

Inventor： Gregory Raymond Bebernitz ,  Mark G. Bock ,  Dumbala Srinivas Reddy ,  Atul Kashinath Hajare ,  Vinod Vyavahare ,  Sandeep Bhausaheb Bhosale ,  Suresh Eknath Kurhade ,  Videsh Salunkhe ,  Nadim S. Shaikh ,  Debnath Bhuniya ,  P. Venkata Palle ,  Lili Feng ,  Jessica Liang

IPC: A61K31/7052 ,  A61K31/706

CPC classification number: A61K31/7052 ,  A61K31/7048 ,  A61K31/706 ,  C07D405/10 ,  C07D407/10 ,  C07D413/10 ,  C07H7/04

Abstract: This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.

Abstract translation: 其中所述变量如上文所定义，其可用于治疗由D-葡萄糖共转运蛋白（SGLT）介导的疾病和病症，例如， 糖尿病。 本发明还提供了治疗这些疾病和病症以及组合物等的治疗方法。