公开(公告)号：US20210155606A1

公开(公告)日：2021-05-27

申请号：US17170690

申请日：2021-02-08

Applicant: NOVARTIS AG

Inventor： Luca ARISTA ,  Sreehari BABU ,  Jianwei BIAN ,  Kai CUI ,  Michael Patrick DILLON ,  Rene LATTMANN ,  Jialiang LI ,  Lv LIAO ,  Dimitrios LIZOS ,  Rita RAMOS ,  Nikolaus Johannes STIEFL ,  Thomas ULLRICH ,  Peggy USSELMANN ,  Xiaoyang WANG ,  Liladhar Murlidhar WAYKOLE ,  Sven WEILER ,  Yubo ZHANG ,  Yizong ZHOU ,  Tingying ZHU

IPC: C07D401/14 ,  C07D405/14 ,  C07D401/10 ,  C07D401/12 ,  C07D409/14 ,  C07D213/82 ,  C07D411/14 ,  C07D491/107 ,  A61P19/00 ,  C07D417/00 ,  C07D413/00 ,  C07D419/00 ,  A61P19/08 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D491/20

Abstract: The invention relates to a compound of formula (1) in free form or in pharmaceutically acceptable salt form to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.

公开(公告)号：US20210145831A1

公开(公告)日：2021-05-20

申请号：US17156785

申请日：2021-01-25

Applicant: Novartis AG ,  Palobiofarma S.L.

Inventor： Kai CUI ,  Julio Cesar CASTRO-PALOMINO LARIA ,  Weiyong KONG

IPC: A61K31/506 ,  A61K39/395 ,  A61K45/06 ,  C07D403/14 ,  C07K16/28

Abstract: This application relates to various crystalline forms of 5-bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine and salt thereof, as well as compositions and methods of using the same. In some embodiments the crystalline forms also contain water (“hydrates”). These materials are useful in the treatment of various diseases, including carcinomas, specifically lung cancer and more specifically non-small cell lung cancer.

公开(公告)号：US20200163963A1

公开(公告)日：2020-05-28

申请号：US16616844

申请日：2018-05-30

Applicant: Novartis AG ,  Palobiofarma S.L.

Inventor： Kai CUI ,  Julio Cesar CASTRO-PALOMINO LARIA ,  Weiyong KONG

IPC: A61K31/506 ,  A61K39/395 ,  C07K16/28 ,  C07D403/14 ,  A61K45/06

Abstract: This application relates to various crystalline forms of 5-bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine and salt thereof, as well as compositions and methods of using the same. In some embodiments the crystalline forms also contain water (“hydrates”). These materials are useful in the treatment of various diseases, including carcinomas, specifically lung cancer and more specifically non-small cell lung cancer.

公开(公告)号：US20200299265A1

公开(公告)日：2020-09-24

申请号：US16884666

申请日：2020-05-27

Applicant: NOVARTIS AG

Inventor： Luca ARISTA ,  Sreehari BABU ,  Jianwei BIAN ,  Kai CUI ,  Michael Patrick DILLON ,  Rene LATTMANN ,  Jialiang LI ,  Lv LIAO ,  Dimitrios LIZOS ,  Rita RAMOS ,  Nikolaus Johannes STIEFL ,  Thomas ULLRICH ,  Peggy USSELMANN ,  Xiaoyang WANG ,  Liladhar Murlidhar WAYKOLE ,  Sven WEILER ,  Yubo ZHANG ,  Yizong ZHOU ,  Tingying ZHU

IPC: C07D401/14 ,  C07D405/14 ,  C07D401/10 ,  C07D401/12 ,  C07D409/14 ,  C07D213/82 ,  C07D411/14 ,  C07D491/107 ,  A61P19/00 ,  C07D417/00 ,  C07D413/00 ,  C07D419/00 ,  A61P19/08 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D491/20

Abstract: The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.

公开(公告)号：US20190161474A1

公开(公告)日：2019-05-30

申请号：US16318250

申请日：2017-07-18

Applicant: NOVARTIS AG

Inventor： Luca ARISTA ,  Sreehari BABU ,  Jianwei BIAN ,  Kai CUI ,  Michael Patrick DILLON ,  Rene LATTMANN ,  Jialiang LI ,  Lv LIAO ,  Dimitrios LIZOS ,  Rita RAMOS ,  Nikolaus Johannes STIEFL ,  Thomas ULLRICH ,  Peggy USSELMANN ,  Xiaoyang WANG ,  Liladhar Murlidhar WAYKOLE ,  Sven WEILER ,  Yubo ZHANG ,  Yizong ZHOU ,  Tingying ZHU

IPC: C07D401/14 ,  C07D401/10 ,  C07D401/12 ,  C07D491/20 ,  C07D405/14 ,  C07D409/14 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  A61P19/08

Abstract: The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form (I) to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.