公开(公告)号：US20190092788A1

公开(公告)日：2019-03-28

申请号：US16141856

申请日：2018-09-25

Applicant: NOVARTIS AG

Inventor： Simone BONAZZI ,  Michael CONNOLLY ,  David Jonathan GLASS ,  Manuel MIHALIC ,  Andrew William PATTERSON ,  Silvio ROGGO ,  Tea SHAVLAKADZE

IPC: C07D498/18 ,  A61P35/00 ,  A61P13/12 ,  A61P1/16

Abstract: The disclosure relates to compounds of formula (I) and pharmaceutically acceptable salts, and compositions thereof, wherein the substituents are as defined herein. Also provided are methods of making compounds of formula (I), and methods involving the compounds or compositions for treating disorders and diseases described herein.

公开(公告)号：US20220242878A1

公开(公告)日：2022-08-04

申请号：US17499433

申请日：2021-10-12

Applicant: NOVARTIS AG

Inventor： Simone BONAZZI ,  Michael CONNOLLY ,  David Jonathan GLASS ,  Manuel MIHALIC ,  Andrew William PATTERSON ,  Silvio ROGGO ,  Tea SHAVLAKADZE

IPC: C07D498/18 ,  A61P1/16 ,  A61P13/12 ,  A61P35/00 ,  A61P25/16 ,  A61P37/00 ,  A61P9/10 ,  A61P19/10 ,  A61P19/00 ,  A61P29/00 ,  A61P31/10 ,  A61P19/02 ,  A61P25/28 ,  A61P3/10 ,  A61P9/12 ,  A61P11/00 ,  A61P3/04 ,  C07F9/6561 ,  A61P25/02

Abstract: The disclosure relates to compounds of formula (I) and pharmaceutically acceptable salts, and compositions thereof, wherein the substituents are as defined herein. Also provided are methods of making compounds of formula (I), and methods involving the compounds or compositions for treating disorders and diseases described herein.