公开(公告)号：US20220242878A1

公开(公告)日：2022-08-04

申请号：US17499433

申请日：2021-10-12

Applicant: NOVARTIS AG

Inventor： Simone BONAZZI ,  Michael CONNOLLY ,  David Jonathan GLASS ,  Manuel MIHALIC ,  Andrew William PATTERSON ,  Silvio ROGGO ,  Tea SHAVLAKADZE

IPC: C07D498/18 ,  A61P1/16 ,  A61P13/12 ,  A61P35/00 ,  A61P25/16 ,  A61P37/00 ,  A61P9/10 ,  A61P19/10 ,  A61P19/00 ,  A61P29/00 ,  A61P31/10 ,  A61P19/02 ,  A61P25/28 ,  A61P3/10 ,  A61P9/12 ,  A61P11/00 ,  A61P3/04 ,  C07F9/6561 ,  A61P25/02

Abstract: The disclosure relates to compounds of formula (I) and pharmaceutically acceptable salts, and compositions thereof, wherein the substituents are as defined herein. Also provided are methods of making compounds of formula (I), and methods involving the compounds or compositions for treating disorders and diseases described herein.

公开(公告)号：US20250026736A1

公开(公告)日：2025-01-23

申请号：US18823254

申请日：2024-09-03

Applicant: NOVARTIS AG

Inventor： Simone BONAZZI ,  Artiom CERNIJENKO ,  Jennifer Stroka COBB ,  Janetta DEWHURST ,  John Ryan KERRIGAN ,  Gary O'BRIEN ,  MooJe SUNG ,  Noel Marie-France THOMSEN ,  Pamela TING

IPC: C07D401/14 ,  A61K31/4545 ,  A61K31/55 ,  A61K45/06 ,  C07D405/14

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

公开(公告)号：US20230037639A1

公开(公告)日：2023-02-09

申请号：US17493055

申请日：2021-10-04

Applicant: Novartis AG

Inventor： Rohan Eric John BECKWITH ,  Simone BONAZZI ,  Artiom CERNIJENKO ,  Fupeng MA ,  Nathaniel F. WARE

IPC: A61K31/454 ,  A61P35/00 ,  A61K31/4545 ,  A61K31/498 ,  C07D401/04 ,  C07D401/14

Abstract: The present disclosure provides a compound of Formula (IT or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein Ra, Rb, Rx, R1, R2, X2, and q are as defined herein, and methods of making and using same.

公开(公告)号：US20220402904A1

公开(公告)日：2022-12-22

申请号：US17124127

申请日：2020-12-16

Applicant: NOVARTIS AG

Inventor： Simone BONAZZI ,  Artiom CERNIJENKO ,  Jennifer Stroka COBB ,  Natalie DALES ,  John Ryan KERRIGAN ,  Philip LAM ,  Hasnain Ahmed MALIK ,  Gary O'BRIEN ,  Andrew W. PATTERSON ,  Noel Marie-France THOMSEN ,  Pamela TING

IPC: C07D413/14 ,  C07D401/14 ,  C07D471/04 ,  C07D417/14 ,  A61K45/06

Abstract: The present disclosure relates to compounds of formula (I′) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

公开(公告)号：US20200017461A1

公开(公告)日：2020-01-16

申请号：US16504375

申请日：2019-07-08

Applicant: Novartis AG

Inventor： Claire ADCOCK ,  Simone BONAZZI ,  Artiom CERNIJENKO ,  Philip LAM ,  Kathryn Taylor LINKENS ,  Hasnain Ahmed MALIK ,  Noel Marie-France THOMSEN ,  Michael Scott VISSER

IPC: C07D401/04 ,  C07D407/14

Abstract: The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein Rx, X1, X2, and R1 are as defined herein, and methods of making and using same.

公开(公告)号：US20230067476A1

公开(公告)日：2023-03-02

申请号：US17520857

申请日：2021-11-08

Applicant: Novartis AG

Inventor： Claire ADCOCK ,  Simone BONAZZI ,  Artiom CERNIJENKO ,  Philip LAM ,  Kathryn Taylor LINKENS ,  Hasnain Ahmed MALIK ,  Noel Marie-France THOMSEN ,  Michael Scott VISSER

IPC: C07D401/04 ,  C07D407/14

Abstract: The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein Rx, X1, X2, and R1 are as defined herein, and methods of making and using same.

公开(公告)号：US20220363671A1

公开(公告)日：2022-11-17

申请号：US17642292

申请日：2020-09-16

Applicant: NOVARTIS AG

Inventor： Jake AXFORD ,  Rohan Eric John BECKWITH ,  Simone BONAZZI ,  Nicole BUSCHMANN ,  Artiom CERNIJENKO ,  Janetta DEWHURST ,  Aleem FAZAL ,  Matthew James HESSE ,  Lauren HOLDER ,  Viktor HORNAK ,  Hidetomo IMASE ,  Rama JAIN ,  Xianming JIN ,  John Ryan KERRIGAN ,  Julie LACHAL ,  Fupeng MA ,  Hasnain Ahmed MALIK ,  James R. MANNING ,  Daniel MCKAY ,  Robert Joseph MOREAU ,  Pierre NIMSGERN ,  Gary O'BRIEN ,  Anna VULPETTI ,  Ken YAMADA ,  Junping ZHAO

IPC: C07D405/04 ,  A61K31/513 ,  C07D471/04 ,  C07D413/04 ,  C07D401/14

Abstract: Described herein are glue degrader compounds, their various targets, their preparation, pharmaceutical compositions comprising them, and their use in the treatment or prevention of conditions, diseases, and disorders mediated by various target proteins.

公开(公告)号：US20210309638A1

公开(公告)日：2021-10-07

申请号：US17343016

申请日：2021-06-09

Applicant: Novartis AG

Inventor： Rohan Eric John BECKWITH ,  Simone BONAZZI ,  Artiom CERNIJENKO ,  Aleem FAZAL ,  Ritesh Bhanudasji TICHKULE ,  Michael Scott VISSER

IPC: C07D401/14 ,  C07D401/04 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D495/04 ,  C07D513/04 ,  A61P35/00

Abstract: The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R1, R2, Rx, X1, n, n1, and q are as defined herein, and methods of making and using same.

公开(公告)号：US20190092788A1

公开(公告)日：2019-03-28

申请号：US16141856

申请日：2018-09-25

Applicant: NOVARTIS AG

Inventor： Simone BONAZZI ,  Michael CONNOLLY ,  David Jonathan GLASS ,  Manuel MIHALIC ,  Andrew William PATTERSON ,  Silvio ROGGO ,  Tea SHAVLAKADZE

IPC: C07D498/18 ,  A61P35/00 ,  A61P13/12 ,  A61P1/16

Abstract: The disclosure relates to compounds of formula (I) and pharmaceutically acceptable salts, and compositions thereof, wherein the substituents are as defined herein. Also provided are methods of making compounds of formula (I), and methods involving the compounds or compositions for treating disorders and diseases described herein.

公开(公告)号：US20250002479A1

公开(公告)日：2025-01-02

申请号：US18826887

申请日：2024-09-06

Applicant: Novartis AG

Inventor： Simone BONAZZI ,  Jennifer Stroka COBB ,  Natalie Alysia DALES ,  Matthew James HESSE ,  Rama JAIN ,  John Ryan KERRIGAN ,  Hasnain Ahmed MALIK ,  James R. MANNING ,  Pamela YF TING

IPC: C07D403/14 ,  A61P7/00 ,  C07D405/14 ,  C07D417/14

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.