Patent search ap:("NOVARTIS AG") AND inv:"Pamela TING" Page 1

1.

发明公开
COMPOSITIONS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES 审中-公开

公开(公告)号：US20230279394A1

公开(公告)日：2023-09-07

申请号：US17786347

申请日：2020-12-16

Applicant: Novartis AG

Inventor： Muluken BELEW , Simone BONAZZI , James BRADNER , Artiom CERNIJENKO , Jennifer Stroka COBB , Natalie DALES , John Ryan KERRIGAN , Philip LAM , Hasnain Ahmed MALIK , Carsten RUSS , Frederic SIGOILLOT , Susan C. STEVENSON , Noel Marie-France THOMSEN , Pamela TING

IPC: C12N15/113 , C12N15/86 , C12N5/07 , A61P7/00

CPC classification number: C12N15/113 , A61P7/00 , C12N5/06 , C12N15/86 , C12N2310/20

Abstract: The present invention is directed to compositions and methods for the treatment of hemoglobinopathies.

2.

发明申请
3-(5-oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione Derivatives and Uses thereof 有权

公开(公告)号：US20250026736A1

公开(公告)日：2025-01-23

申请号：US18823254

申请日：2024-09-03

Applicant: NOVARTIS AG

Inventor： Simone BONAZZI , Artiom CERNIJENKO , Jennifer Stroka COBB , Janetta DEWHURST , John Ryan KERRIGAN , Gary O'BRIEN , MooJe SUNG , Noel Marie-France THOMSEN , Pamela TING

IPC: C07D401/14 , A61K31/4545 , A61K31/55 , A61K45/06 , C07D405/14

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

3.

发明申请
3-(5-methoxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione Derivatives and Uses thereof 有权

公开(公告)号：US20220402904A1

公开(公告)日：2022-12-22

申请号：US17124127

申请日：2020-12-16

Applicant: NOVARTIS AG

Inventor： Simone BONAZZI , Artiom CERNIJENKO , Jennifer Stroka COBB , Natalie DALES , John Ryan KERRIGAN , Philip LAM , Hasnain Ahmed MALIK , Gary O'BRIEN , Andrew W. PATTERSON , Noel Marie-France THOMSEN , Pamela TING

IPC: C07D413/14 , C07D401/14 , C07D471/04 , C07D417/14 , A61K45/06

Abstract: The present disclosure relates to compounds of formula (I′) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

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