公开(公告)号：US09156894B2

公开(公告)日：2015-10-13

申请号：US13845305

申请日：2013-03-18

Applicant: Novartis AG

Inventor： Vega Masignani ,  Maria Scarselli ,  Rino Rappuoli ,  Mariagrazia Pizza ,  Marzia Monica Giuliani

IPC: A61K39/095 ,  C12P21/04 ,  C07K14/22 ,  A61K38/16

CPC classification number: C07K14/22 ,  A61K38/164 ,  A61K39/095 ,  C07K2319/00

Abstract: NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.

Abstract translation: NMB1870是脑膜炎奈瑟氏球菌中的蛋白质。 NMB1870的三个家族是已知的。 为了增加NMB1870蛋白质引起家族之间交叉反应的抗体的能力，NMB1870被设计。 序列可以从一个NMB1870家族代替到另一个家族的相应位置。 来自不同家族的NMB1870序列的蛋白质可以彼此连接。

公开(公告)号：US20150132339A1

公开(公告)日：2015-05-14

申请号：US14381090

申请日：2013-03-07

Applicant: NOVARTIS AG

Inventor： Simone Bufali ,  Paolo Costantino ,  Michele Pallaoro ,  Derek O'hagan ,  Rino Rappuoli ,  Manmohan Singh

IPC: A61K39/09 ,  A61K33/08 ,  A61K31/4745 ,  A61K39/39

CPC classification number: A61K39/092 ,  A61K31/4375 ,  A61K31/4745 ,  A61K33/06 ,  A61K33/08 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/6037 ,  A61K2300/00

Abstract: The efficacy of S. pneumoniae vaccines can be enhanced by adjuvanting S. pneumoniae saccharide and/or protein antigens with a mixture of a TLR agonist (preferably a TLR7 agonist) and an insoluble metal salt (preferably an aluminium salt). The TLR agonist is typically adsorbed to the metal salt. The S. pneumoniae antigen can also be adsorbed to the metal salt.

Abstract translation: 通过用TLR激动剂（优选TLR7激动剂）和不溶性金属盐（优选铝盐）的混合物佐剂肺炎链球菌糖和/或蛋白质抗原来增强肺炎链球菌疫苗的功效。 TLR激动剂通常被吸附到金属盐上。 肺炎链球菌抗原也可以被吸附到金属盐上。

公开(公告)号：US09468673B2

公开(公告)日：2016-10-18

申请号：US13736850

申请日：2013-01-08

Applicant: Novartis AG

Inventor： Mariagrazia Pizza ,  Maria Scarselli ,  Marzia Monica Giuliani ,  Maria Arico ,  Rino Rappuoli

IPC: A61K39/095 ,  A61K39/02 ,  A61K39/116 ,  A61K39/00 ,  A61K39/385 ,  A61K38/00 ,  C07K1/00 ,  C07K14/22

CPC classification number: A61K39/095 ,  A61K39/00 ,  C07K14/22

Abstract: fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are cross-reactive between the families, fHBP is selected or engineered to have a sequence which can elicit broad-spectrum bactericidal anti-meningococcal antibodies after administration to a host animal.

Abstract translation: fHBP是脑膜炎奈瑟菌中的蛋白质。 已知三个fHBP家族。 为了增加fHBP蛋白引起家族之间交叉反应的抗体的能力，选择或改造fHBP以具有在给予宿主动物后可引发广谱杀菌抗脑膜炎球菌抗体的序列。