公开(公告)号：US20200345732A1

公开(公告)日：2020-11-05

申请号：US16934787

申请日：2020-07-21

Applicant: Novartis AG

Inventor： Atwood Kim CHEUNG ,  Donovan Noel CHIN ,  Natalie DALES ,  Aleem FAZAL ,  Timothy Brian HURLEY ,  John KERRIGAN ,  Gary O'BRIEN ,  Lei SHU ,  Robert SUN ,  Moo Je SUNG

IPC: A61K31/501 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  C07D237/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  A61K31/41 ,  A61K31/427 ,  C07D237/06

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20170290828A1

公开(公告)日：2017-10-12

申请号：US15364248

申请日：2016-11-29

Applicant: NOVARTIS AG

Inventor： Atwood Kim CHEUNG ,  Donovan Noel CHIN ,  Natalie DALES ,  Aleem FAZAL ,  Timothy HURLEY ,  John KERRIGAN ,  Gary O'BRIEN ,  Lei SHU ,  Robert SUN ,  Moo Je SUNG

IPC: A61K31/501 ,  A61K31/41 ,  C07D237/06 ,  C07D413/14 ,  C07D405/14 ,  C07D403/10 ,  C07D403/12 ,  A61K31/427 ,  C07D401/14

CPC classification number: A61K31/501 ,  A61K31/41 ,  A61K31/427 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  C07D237/06 ,  C07D237/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20220387428A1

公开(公告)日：2022-12-08

申请号：US17644045

申请日：2021-12-13

Applicant: Novartis AG

Inventor： Atwood Kim CHEUNG ,  Donovan Noel CHIN ,  Natalie DALES ,  Aleem FAZAL ,  Timothy Brian HURLEY ,  John KERRIGAN ,  Gary O'BRIEN ,  Lei SHU ,  Robert SUN ,  Moo Je SUNG

IPC: A61K31/501 ,  A61P21/00 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  C07D237/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  A61K31/41 ,  A61K31/427 ,  C07D237/06

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20190358226A1

公开(公告)日：2019-11-28

申请号：US16237907

申请日：2019-01-02

Applicant: Novartis AG

Inventor： Atwood Kim CHEUNG ,  Donovan Noel CHIN ,  Natalie DALES ,  Aleem FAZAL ,  Timothy Brian HURLEY ,  John KERRIGAN ,  Gary O'BRIEN ,  Lei SHU ,  Robert SUN ,  Moo Je SUNG

IPC: A61K31/501 ,  A61K31/427 ,  C07D487/10 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  C07D237/06 ,  C07D487/04 ,  A61K45/06 ,  C07D237/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  A61K31/41

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.