公开(公告)号：US20220387428A1

公开(公告)日：2022-12-08

申请号：US17644045

申请日：2021-12-13

Applicant: Novartis AG

Inventor： Atwood Kim CHEUNG ,  Donovan Noel CHIN ,  Natalie DALES ,  Aleem FAZAL ,  Timothy Brian HURLEY ,  John KERRIGAN ,  Gary O'BRIEN ,  Lei SHU ,  Robert SUN ,  Moo Je SUNG

IPC: A61K31/501 ,  A61P21/00 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  C07D237/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  A61K31/41 ,  A61K31/427 ,  C07D237/06

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20200345732A1

公开(公告)日：2020-11-05

申请号：US16934787

申请日：2020-07-21

Applicant: Novartis AG

Inventor： Atwood Kim CHEUNG ,  Donovan Noel CHIN ,  Natalie DALES ,  Aleem FAZAL ,  Timothy Brian HURLEY ,  John KERRIGAN ,  Gary O'BRIEN ,  Lei SHU ,  Robert SUN ,  Moo Je SUNG

IPC: A61K31/501 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  C07D237/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  A61K31/41 ,  A61K31/427 ,  C07D237/06

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20170290828A1

公开(公告)日：2017-10-12

申请号：US15364248

申请日：2016-11-29

Applicant: NOVARTIS AG

Inventor： Atwood Kim CHEUNG ,  Donovan Noel CHIN ,  Natalie DALES ,  Aleem FAZAL ,  Timothy HURLEY ,  John KERRIGAN ,  Gary O'BRIEN ,  Lei SHU ,  Robert SUN ,  Moo Je SUNG

IPC: A61K31/501 ,  A61K31/41 ,  C07D237/06 ,  C07D413/14 ,  C07D405/14 ,  C07D403/10 ,  C07D403/12 ,  A61K31/427 ,  C07D401/14

CPC classification number: A61K31/501 ,  A61K31/41 ,  A61K31/427 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  C07D237/06 ,  C07D237/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20190358226A1

公开(公告)日：2019-11-28

申请号：US16237907

申请日：2019-01-02

Applicant: Novartis AG

Inventor： Atwood Kim CHEUNG ,  Donovan Noel CHIN ,  Natalie DALES ,  Aleem FAZAL ,  Timothy Brian HURLEY ,  John KERRIGAN ,  Gary O'BRIEN ,  Lei SHU ,  Robert SUN ,  Moo Je SUNG

IPC: A61K31/501 ,  A61K31/427 ,  C07D487/10 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  C07D237/06 ,  C07D487/04 ,  A61K45/06 ,  C07D237/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  A61K31/41

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20190077773A1

公开(公告)日：2019-03-14

申请号：US16129199

申请日：2018-09-12

Applicant: NOVARTIS AG

Inventor： Natalie DALES ,  Paul GORMISKY ,  John Ryan KERRIGAN ,  Lei SHU

IPC: C07D249/10 ,  C07D405/10 ,  C07D403/10 ,  C07D401/10 ,  C07D401/14 ,  C07D413/10 ,  C07D231/14 ,  A61P21/00 ,  A61P25/28 ,  A61P17/02 ,  A61P27/16

Abstract: The present disclosure provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, and its therapeutic uses for activating a growth factor pathway, promoting wound healing, promoting tissue repair, and treating hearing loss, skeletal muscle loss, organ degeneration, tissue damage, neurodegeneration, and muscular atrophy. The disclosure further provides pharmaceutical compositions and combinations. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.