公开(公告)号：US20220387428A1

公开(公告)日：2022-12-08

申请号：US17644045

申请日：2021-12-13

Applicant: Novartis AG

Inventor： Atwood Kim CHEUNG ,  Donovan Noel CHIN ,  Natalie DALES ,  Aleem FAZAL ,  Timothy Brian HURLEY ,  John KERRIGAN ,  Gary O'BRIEN ,  Lei SHU ,  Robert SUN ,  Moo Je SUNG

IPC: A61K31/501 ,  A61P21/00 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  C07D237/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  A61K31/41 ,  A61K31/427 ,  C07D237/06

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20200231569A1

公开(公告)日：2020-07-23

申请号：US16835938

申请日：2020-03-31

Applicant: Novartis AG

Inventor： Rohan Eric John BECKWITH ,  Simone BONAZZI ,  Artiom CERNIJENKO ,  Aleem FAZAL ,  Ritesh Bhanudasji TICHKULE ,  Michael Scott VISSER

IPC: C07D401/14 ,  C07D401/04 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D495/04 ,  C07D513/04 ,  A61P35/00

Abstract: The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R1, R2, Rx, X1, n, n1, and q are as defined herein, and methods of making and using same.

公开(公告)号：US20200345732A1

公开(公告)日：2020-11-05

申请号：US16934787

申请日：2020-07-21

Applicant: Novartis AG

Inventor： Atwood Kim CHEUNG ,  Donovan Noel CHIN ,  Natalie DALES ,  Aleem FAZAL ,  Timothy Brian HURLEY ,  John KERRIGAN ,  Gary O'BRIEN ,  Lei SHU ,  Robert SUN ,  Moo Je SUNG

IPC: A61K31/501 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  C07D237/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  A61K31/41 ,  A61K31/427 ,  C07D237/06

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20190062309A1

公开(公告)日：2019-02-28

申请号：US16108713

申请日：2018-08-22

Applicant: Novartis AG

Inventor： Rohan Eric John BECKWITH ,  Simone BONAZZI ,  Artiom CERNIJENKO ,  Aleem FAZAL ,  Ritesh Bhanudasji TICHKULE ,  Michael Scott VISSER

IPC: C07D401/14 ,  A61P35/00

CPC classification number: C07D401/14 ,  A61P35/00 ,  C07D401/04 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D495/04 ,  C07D513/04

Abstract: The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R1, R2, Rx, X1, n, n1, and q are as defined herein, and methods of making and using same.

公开(公告)号：US20170290828A1

公开(公告)日：2017-10-12

申请号：US15364248

申请日：2016-11-29

Applicant: NOVARTIS AG

Inventor： Atwood Kim CHEUNG ,  Donovan Noel CHIN ,  Natalie DALES ,  Aleem FAZAL ,  Timothy HURLEY ,  John KERRIGAN ,  Gary O'BRIEN ,  Lei SHU ,  Robert SUN ,  Moo Je SUNG

IPC: A61K31/501 ,  A61K31/41 ,  C07D237/06 ,  C07D413/14 ,  C07D405/14 ,  C07D403/10 ,  C07D403/12 ,  A61K31/427 ,  C07D401/14

CPC classification number: A61K31/501 ,  A61K31/41 ,  A61K31/427 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  C07D237/06 ,  C07D237/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20220363671A1

公开(公告)日：2022-11-17

申请号：US17642292

申请日：2020-09-16

Applicant: NOVARTIS AG

Inventor： Jake AXFORD ,  Rohan Eric John BECKWITH ,  Simone BONAZZI ,  Nicole BUSCHMANN ,  Artiom CERNIJENKO ,  Janetta DEWHURST ,  Aleem FAZAL ,  Matthew James HESSE ,  Lauren HOLDER ,  Viktor HORNAK ,  Hidetomo IMASE ,  Rama JAIN ,  Xianming JIN ,  John Ryan KERRIGAN ,  Julie LACHAL ,  Fupeng MA ,  Hasnain Ahmed MALIK ,  James R. MANNING ,  Daniel MCKAY ,  Robert Joseph MOREAU ,  Pierre NIMSGERN ,  Gary O'BRIEN ,  Anna VULPETTI ,  Ken YAMADA ,  Junping ZHAO

IPC: C07D405/04 ,  A61K31/513 ,  C07D471/04 ,  C07D413/04 ,  C07D401/14

Abstract: Described herein are glue degrader compounds, their various targets, their preparation, pharmaceutical compositions comprising them, and their use in the treatment or prevention of conditions, diseases, and disorders mediated by various target proteins.

公开(公告)号：US20210309638A1

公开(公告)日：2021-10-07

申请号：US17343016

申请日：2021-06-09

Applicant: Novartis AG

Inventor： Rohan Eric John BECKWITH ,  Simone BONAZZI ,  Artiom CERNIJENKO ,  Aleem FAZAL ,  Ritesh Bhanudasji TICHKULE ,  Michael Scott VISSER

IPC: C07D401/14 ,  C07D401/04 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D495/04 ,  C07D513/04 ,  A61P35/00

Abstract: The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R1, R2, Rx, X1, n, n1, and q are as defined herein, and methods of making and using same.

公开(公告)号：US20190358226A1

公开(公告)日：2019-11-28

申请号：US16237907

申请日：2019-01-02

Applicant: Novartis AG

Inventor： Atwood Kim CHEUNG ,  Donovan Noel CHIN ,  Natalie DALES ,  Aleem FAZAL ,  Timothy Brian HURLEY ,  John KERRIGAN ,  Gary O'BRIEN ,  Lei SHU ,  Robert SUN ,  Moo Je SUNG

IPC: A61K31/501 ,  A61K31/427 ,  C07D487/10 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  C07D237/06 ,  C07D487/04 ,  A61K45/06 ,  C07D237/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  A61K31/41

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.