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公开(公告)号：US20180094033A1
公开(公告)日：2018-04-05
申请号：US15805453
申请日：2017-11-07
发明人： John TELFORD , Vega MASIGNANI , Maria SCARSELLI , Guido GRANDI , Herve TETTELIN , Claire FRASER
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
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公开(公告)号：US20160264632A1
公开(公告)日：2016-09-15
申请号：US15166010
申请日：2016-05-26
发明人： John TELFORD , Vega MASIGNANI , Maria SCARSELLI , Guido GRANDI , Herve TETTELIN , Claire FRASER
IPC分类号： C07K14/315
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
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公开(公告)号：US20150086582A1
公开(公告)日：2015-03-26
申请号：US14450075
申请日：2014-08-01
发明人： Claire FRASER , Cesira GALEOTTI , Guido GRANDI , Erin HICKEY , Vega MASIGNANI , Marirosa MORA , Jeremy PETERSEN , Mariagrazia PIZZA , Rino RAPPUOLI , Giulio RATTI , Vincenzo SCARLATO , Maria SCARSELLI , Herve TETTELIN , J. Craig VENTER
IPC分类号： C07K14/22
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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公开(公告)号：US20150079124A1
公开(公告)日：2015-03-19
申请号：US14450082
申请日：2014-08-01
发明人： Claire FRASER , Cesira GALEOTTI , Guido GRANDI , Erin HICKEY , Vega MASIGNANI , Marirosa MORA , Jeremy PETERSEN , Mariagrazia PIZZA , Rino RAPPUOLI , Giulio RATTI , Vincenzo SCARLATO , Maria SCARSELLI , Herve TETTELIN , J. Craig VENTER
IPC分类号： C07K14/22
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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公开(公告)号：US20150132337A1
公开(公告)日：2015-05-14
申请号：US14540627
申请日：2014-11-13
申请人： NOVARTIS AG
发明人： Guido GRANDI , Immaculada MARGARIT Y ROS , Sabrina CAPO , Giuliano BENSI , Andrea Guido Oreste MANETTI
IPC分类号： C07K14/315
CPC分类号： C07K14/315 , A61K39/092 , A61K2039/507 , A61K2039/6037 , C07K16/1275 , Y02A50/466 , Y02A50/478 , A61K2300/00
摘要： Compositions useful for reducing the risk of, preventing, and/or treating S. pyogenes (GAS) infections which comprise combinations of GAS antigens, nucleic acid molecules encoding the antigens, or antibodies which specifically bind to the antigens.
摘要翻译： 可用于降低包含GAS抗原，编码抗原的核酸分子或特异性结合抗原的抗体的化脓性链球菌（GAS）感染的风险，预防和/或治疗的风险，风险，和/或治疗的组合物。
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公开(公告)号：US20140178425A1
公开(公告)日：2014-06-26
申请号：US14171537
申请日：2014-02-03
申请人： Novartis AG
发明人： Fabio BAGNOLI , Massimiliano BIAGINI , Luigi FIASCHI , Guido GRANDI , Ravi Pratap Narayan MISHRA , Nathalie NORAIS , Maria SCARSELLI
IPC分类号： A61K39/085 , C07K14/31
CPC分类号： A61K39/085 , A61K39/00 , C07K14/31 , C07K2319/00
摘要： An effective Staphylococcus aureus vaccine may require several antigenic components, and so various combinations of S. aureus antigens are identified for use in immunisation. These polypeptides may optionally be used in combination with S. aureus saccharides.
摘要翻译： 有效的金黄色葡萄球菌疫苗可能需要几种抗原成分，因此鉴定出金黄色葡萄球菌抗原的各种组合用于免疫。 这些多肽可以任选地与金黄色葡萄球菌组合使用。
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公开(公告)号：US20150202280A1
公开(公告)日：2015-07-23
申请号：US14627270
申请日：2015-02-20
申请人： Novartis AG
IPC分类号： A61K39/118 , C07K16/12
CPC分类号： A61K39/118 , A61K39/00 , A61K2039/55544 , A61K2039/55561 , C07K14/295 , C07K16/125 , C07K2317/76 , G01N2333/295
摘要： An immunogenic Chlamydia HtrA protein, which has one or more mutations relative to wild-type Chlamydia HtrA that result in a reduced or eliminated protease activity relative to the protease activity of wild-type Chlamydia HtrA. Preferably, it is the serine protease activity that is reduced or eliminated.
摘要翻译： 免疫原性衣原体HtrA蛋白，其相对于野生型衣原体HtrA具有一个或多个相对于野生型衣原体HtrA的蛋白酶活性降低或消除的蛋白酶活性的一个或多个突变。 优选地，减少或消除丝氨酸蛋白酶活性。
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公开(公告)号：US20140093510A1
公开(公告)日：2014-04-03
申请号：US14035750
申请日：2013-09-24
申请人： Novartis AG
IPC分类号： A61K39/118 , G01N33/569 , A61K39/395
CPC分类号： A61K39/118 , A61K39/3955 , A61K2039/543 , A61K2039/545 , A61K2039/55544 , A61K2039/55561 , A61K2039/57 , C07K14/295 , C07K16/125 , G01N33/56927 , G01N2333/295 , G01N2469/10
摘要： The invention provides Chlamydia antigens for use in the treatment, prevention and/or diagnosis of Chlamydia infection. In particular, the invention provides antigens CT733, CT1 53, CT601, CT279, CT443, CT372, CT456, CT381, CT255, CT341, CT716, CT745, CT387, CT812, CT869, CT166, CT175, CT163, CT214, CT721, CT127, CT043, CT823 and/or CT600 from C. trachomatis for the treatment, prevention or diagnosis of Chlamydia infection.
摘要翻译： 本发明提供用于治疗，预防和/或诊断衣原体感染的衣原体抗原。 本发明提供抗原CT733，CT1,53，CT601，CT279，CT443，CT372，CT456，CT381，CT255，CT341，CT716，CT745，CT387，CT812，CT869，CT166，CT175，CT163，CT214，CT721，CT127， CT043，CT823和/或来自沙眼衣原体的CT600用于治疗，预防或诊断衣原体感染。
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