公开(公告)号：US3669843A

公开(公告)日：1972-06-13

申请号：US3669843D

申请日：1969-08-15

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： AUNSTRUP KNUD ,  MAHLER JORN LEO

IPC: C12N9/06 ,  C07G7/028 ,  C12D13/10

CPC classification number: C12N9/0046 ,  Y10S435/832

Abstract: Production of the enzyme uricase by aerobic cultivation of a strain of Bacillus fastidiosus or a variant thereof.

Abstract translation: 通过需氧培养芽孢杆菌菌株或其变种产生酶尿苷酶。

公开(公告)号：US3840433A

公开(公告)日：1974-10-08

申请号：US25164672

申请日：1972-05-09

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： OUTTRUP HELLE ,  AUNSTRUP KNUD ,  ANDRESSEN OTTO

IPC: C14C1/06 ,  C12B1/00

CPC classification number: C14C1/065

Abstract: Dehairing of skins and hides in an alkaline medium pH of about 12.5, such as by lime treatment, is accelerated by inclusion of certain alkali resistant proteolytic enzymes. Preferred embodiments are the proteases from Bacillus alcalophilus, and from the Bacillus sp. strains NCIB 10313, 10317, 10147.

公开(公告)号：US3677902A

公开(公告)日：1972-07-18

申请号：US3677902D

申请日：1966-06-21

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： AUNSTRUP KNUD

IPC: C12N9/34 ,  F21V8/00 ,  G09F13/18 ,  C12D13/10

CPC classification number: C12N9/2428 ,  G09F2013/185 ,  Y10S435/911 ,  Y10S435/917 ,  Y10S435/939

Abstract: A PROCESS OF PRODUCING AMYLOGLUCOSIDASE FREE OF ANY DETECTABLE AMOUNTS OF TRANSGLUCOSIDASE WHEREIN A STRAIN OF ASPERGILLUS NIGER V. TIEGHEM SELECTED FROM THE GROUP CBS NO. 262.65, CBS NO. 263.65 AND CBS NO. 103.66 OR A NATURAL OR ARTIFICAL MUTANT OR VARIANT THEREOF IS SUBJECTED TO SUBMERGED GROWTH IN A NUTRIENT MEDIUM.

公开(公告)号：US3723250A

公开(公告)日：1973-03-27

申请号：US3723250D

申请日：1968-09-23

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： AUNSTRUP KNUD ,  ANDRESEN OTTO ,  OUTTRUP HELLE

IPC: A61K8/66 ,  A61Q9/04 ,  C11D3/386 ,  C12N9/54 ,  C14C1/06 ,  C12D13/10

CPC classification number: A61Q9/04 ,  A61K8/66 ,  C11D3/386 ,  C12N9/54 ,  C14C1/065 ,  Y10S435/832

Abstract: The invention relates to enzyme preparations containing novel proteolytic enzymes produced by cultivation of novel species of the genus Bacillus and showing useful activity at high alkalinities. The invention also relates to production of the novel proteolytic enzymes by cultivation of the novel species of the genus Bacillus in a nutrient medium having a pH-value within the range of 7 to 12. Finally the invention relates to a process of isolating the novel species referred to by effecting the isolation on nutrient media having a pH-value within the range of 9 to 11. The novel enzymes are particularly useful in detergent and dehairing compositions.

Abstract translation: 本发明涉及含有通过培养芽孢杆菌属新品种而产生的新型蛋白水解酶的酶制剂，并且在高浓度条件下显示出有用的活性。 本发明还涉及通过在pH值在7至12范围内的营养培养基中培养芽孢杆菌属的新物种来生产新的蛋白水解酶。最后本发明涉及一种分离新物种的方法 通过对pH值在9至11范围内的营养介质进行隔离来提及。新型酶特别可用于洗涤剂和脱毛组合物中。

公开(公告)号：US3674643A

公开(公告)日：1972-07-04

申请号：US3674643D

申请日：1968-11-01

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： AUNSTRUP KNUD ,  ANDRESEN OTTO ,  OUTTRUP HELLE

IPC: C02F3/34 ,  C11D3/386 ,  C12N9/54 ,  C12D13/10

CPC classification number: C12N9/54 ,  C02F3/34 ,  C02F3/342 ,  C11D3/386 ,  Y10S435/832 ,  Y10S435/839

Abstract: A method of making proteolytic enzyme preparations having maximum activity at high alkalinity by submerged aerobic cultivation of strains of Bacillus alcalophilus in a nutrient medium containing assimilable carbon and nitrogen sources, while maintaining the pH-value of the nutrient medium between 7.5 and 11.

Abstract translation: 一种制备蛋白水解酶制剂的方法，其通过在含有可同化碳和氮源的营养培养基中浸没嗜碱芽孢杆菌菌株浸没好氧培养，在高碱度下具有最大活性，同时保持营养培养基的pH值在7.5和11之间。