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1.发明公开公开(公告)号：US20230201144A1
公开(公告)日：2023-06-29
申请号：US17999843
申请日：2021-05-31
申请人： NovoMedix, LLC
发明人： Cathy A. Swindlehurst , Kyle W.H. Chan , Laura Graciana Corral , Paul E. Erdman , Leah M. Fung , Imelda Lam , Robert W. Sullivan , Eduardo Torres
IPC分类号： A61K31/18 , A61K31/4465 , A61K31/44
CPC分类号： A61K31/18 , A61K31/4465 , A61K31/44
摘要： Provided herein are a biarylsulfonamide, e.g., a compound of Formula (IA), and a pharmaceutical composition thereof. Also provided herein is a method of treating a fibrotic lung disease with a biarylsulfonamide, alone or in combination with an antifibrotic agent. Additionally, provided herein is a method of slowing the rate of decline in pulmonary function in a subject having a fibrotic lung disease with a biarylsulfonamide, alone or in combination with an antifibrotic agent.
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公开(公告)号：US20140155477A1
公开(公告)日：2014-06-05
申请号：US14092425
申请日：2013-11-27
申请人： NOVOMEDIX, LLC
IPC分类号： C07C311/21 , A61K45/06 , A61K31/337 , A61K31/18
CPC分类号： C07C311/21 , A61K31/18 , A61K31/337 , A61K45/06
摘要： Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
摘要翻译： 本文提供取代的联芳基磺酰胺化合物，包含化合物的药物组合物，其制备方法及其用途。 本文提供的化合物可用于治疗，预防和/或改善各种疾病，包括癌症和增殖性疾病。 在一个实施方案中，本文提供的化合物调节蛋白质翻译的起始。 在一个实施方案中，本文提供的化合物与外科，放射治疗，免疫治疗和/或一种或多种另外的抗癌药物结合使用以治疗，预防和/或改善癌症和增殖性疾病。
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公开(公告)号：US20180327353A1
公开(公告)日：2018-11-15
申请号：US16046893
申请日：2018-07-26
申请人： NovoMedix, LLC
IPC分类号： C07C311/21 , A61K45/06 , A61K31/18 , A61K31/337
CPC分类号： C07C311/21 , A61K31/18 , A61K31/337 , A61K45/06
摘要： Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
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公开(公告)号：US20170158627A1
公开(公告)日：2017-06-08
申请号：US15434531
申请日：2017-02-16
申请人： NovoMedix, LLC
IPC分类号： C07C311/21 , A61K45/06 , A61K31/18
CPC分类号： C07C311/21 , A61K31/18 , A61K31/337 , A61K45/06
摘要： Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
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公开(公告)号：US20160024040A1
公开(公告)日：2016-01-28
申请号：US14871552
申请日：2015-09-30
申请人： NovoMedix, LLC
IPC分类号： C07D307/68 , A61K31/341
CPC分类号： C07D307/68 , A61K31/341 , A61K45/06
摘要： Provided herein are substituted furanyl compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
摘要翻译： 本文提供取代的呋喃基化合物，包含化合物的药物组合物，其制备方法及其使用方法。 本文提供的化合物可用于治疗，预防和/或改善各种疾病，包括癌症和增殖性疾病。 在一个实施方案中，本文提供的化合物调节eIF4E活性。 在一个实施方案中，本文提供的化合物调节Hedgehog途径活性。 在一个实施方案中，本文提供的化合物与外科，放射治疗，免疫治疗和/或一种或多种另外的抗癌药物结合使用以治疗，预防和/或改善癌症和增殖性疾病。
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6.发明申请公开(公告)号：US20180127359A1
公开(公告)日：2018-05-10
申请号：US15806952
申请日：2017-11-08
申请人： NovoMedix, LLC
IPC分类号： C07C279/04 , A61K9/28 , A61K31/155 , A61K45/06 , A61P9/12 , A61P9/00 , A61P3/10
CPC分类号： C07C279/04 , A61K9/28 , A61K31/155 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/4985 , A61K31/522 , A61K31/64 , A61K31/70 , A61K31/702 , A61K38/26 , A61K45/06 , A61P3/10 , A61P9/00 , A61P9/12 , C07B2200/13 , A61K2300/00
摘要： Provided herein are nitrite salts of 1,1-dimethylbiguanide; and isotopic variants thereof; and pharmaceutically acceptable hydrates and solvates thereof. Also provided herein are their pharmaceutical compositions and methods of use for treating, preventing, or ameliorating one or more symptoms of diseases associated with and/or caused by an abnormal blood glucose level. Further provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a cardiovascular disease.
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公开(公告)号：US20160016899A1
公开(公告)日：2016-01-21
申请号：US14871472
申请日：2015-09-30
申请人： NovoMedix, LLC
IPC分类号： C07C311/21 , A61K31/337 , A61K31/18
CPC分类号： C07C311/21 , A61K31/18 , A61K31/337 , A61K45/06
摘要： Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
摘要翻译： 本文提供取代的联芳基磺酰胺化合物，包含化合物的药物组合物，其制备方法及其用途。 本文提供的化合物可用于治疗，预防和/或改善各种疾病，包括癌症和增殖性疾病。 在一个实施方案中，本文提供的化合物调节蛋白质翻译的起始。 在一个实施方案中，本文提供的化合物与外科，放射治疗，免疫治疗和/或一种或多种另外的抗癌药物结合使用以治疗，预防和/或改善癌症和增殖性疾病。
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