公开(公告)号：US20130157325A1

公开(公告)日：2013-06-20

申请号：US13761633

申请日：2013-02-07

Applicant: NOVOZYMES A/S

Inventor： Leonardo De Maria ,  Jesper Brask ,  Michael Skjot ,  Shamkant Anant Patkar ,  Kim Borch ,  Allan Svendsen

IPC: C12N9/20 ,  C12P7/40 ,  C12P7/64 ,  C12P7/62

CPC classification number: C12N9/20 ,  C12P7/40 ,  C12P7/62 ,  C12P7/6418 ,  C12Y301/01003

Abstract: Molecular dynamics (MD) simulation on the three-dimensional structure of Candida anrtarctica lipase B revealed two hitherto unknown lids with a marked mobility, and this discovery was used to design lipolytic enzyme variants with increased lipolytic enzyme activity.

Abstract translation: 针对念珠菌脂肪酶B的三维结构的分子动力学（MD）模拟显示两个具有明显迁移率的未知盖，并且该发现用于设计具有增加的脂肪分解酶活性的脂肪分解酶变体。