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公开(公告)号：US08383813B2
公开(公告)日：2013-02-26
申请号：US13234501
申请日：2011-09-16
申请人： Nadine C. Becknell , Peter D. Brown , Reddeppareddy Dandu , James L. Diebold , Diane E. Gingrich , Robert L. Hudkins , Bruce A. Ruggeri , Ming Tao , Theodore L. Underiner , Allison L. Zulli
发明人： Nadine C. Becknell , Peter D. Brown , Reddeppareddy Dandu , James L. Diebold , Diane E. Gingrich , Robert L. Hudkins , Bruce A. Ruggeri , Ming Tao , Theodore L. Underiner , Allison L. Zulli
IPC分类号： C07D239/42 , C07D403/14
CPC分类号： C07D487/14 , C07D487/04
摘要： The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
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公开(公告)号：US20120004253A1
公开(公告)日：2012-01-05
申请号：US13234501
申请日：2011-09-16
申请人： Nadine C. Becknell , Peter D. Brown , James L. Diebold , Diane E. Gingrich , Robert L. Hudkins , Reddeppareddy Dandu , Bruce A. Ruggeri , Ming Tao , Theodore L. Underiner , Allison L. Zulli
发明人： Nadine C. Becknell , Peter D. Brown , James L. Diebold , Diane E. Gingrich , Robert L. Hudkins , Reddeppareddy Dandu , Bruce A. Ruggeri , Ming Tao , Theodore L. Underiner , Allison L. Zulli
IPC分类号： A61K31/506 , A61P35/00 , A61P29/00 , A61P25/08 , A61P17/06 , A61P9/10 , A61P17/02 , A61P25/28 , C07D487/14 , A61P19/02
CPC分类号： C07D487/14 , C07D487/04
摘要： The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
摘要翻译： 本发明一般涉及选择的稠合吡咯并唑，包括其药物组合物和用其治疗疾病的方法。 本发明还涉及制备这些稠合的吡咯并咔唑的中间体和方法。
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公开(公告)号：US20100152196A1
公开(公告)日：2010-06-17
申请号：US12708306
申请日：2010-02-18
申请人： Nadine C. Becknell , James L. Diebold , Diane E. Gingrich , Robert L. Hudkins , Dandu R. Reddy , Ming Tao , Theodore L. Underiner , Allison L. Zulli
发明人： Nadine C. Becknell , James L. Diebold , Diane E. Gingrich , Robert L. Hudkins , Dandu R. Reddy , Ming Tao , Theodore L. Underiner , Allison L. Zulli
IPC分类号： A61K31/501 , A61K31/506 , A61K31/4439 , A61K31/4162 , C07D487/14 , A61P25/16 , A61P25/00 , A61P25/28
CPC分类号： C07D487/14 , C07D487/04
摘要： The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
摘要翻译： 本发明一般涉及选择的稠合吡咯并唑，包括其药物组合物和用其治疗疾病的方法。 本发明还涉及制备这些稠合的吡咯并咔唑的中间体和方法。
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公开(公告)号：US07169802B2
公开(公告)日：2007-01-30
申请号：US11017947
申请日：2004-12-22
申请人： Robert L. Hudkins , Allison L. Zulli , Dandu R. Reddy , Diane E. Gingrich , Ming Tao , Nadine C. Becknell , James L. Diebold , Theodore L. Underiner
发明人： Robert L. Hudkins , Allison L. Zulli , Dandu R. Reddy , Diane E. Gingrich , Ming Tao , Nadine C. Becknell , James L. Diebold , Theodore L. Underiner
IPC分类号： A61K31/4162 , A61K31/506 , A61K31/407 , C07D239/42 , C07D231/54 , C07D487/14
CPC分类号： C07D487/14 , C07D487/04
摘要： The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
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公开(公告)号：US07671064B2
公开(公告)日：2010-03-02
申请号：US11477639
申请日：2006-06-29
申请人： Robert L. Hudkins , Allison L. Zulli , Dandu R. Reddy , Diane E. Gingrich , Ming Tao , Nadine C. Becknell , James L. Diebold , Theodore L. Underiner
发明人： Robert L. Hudkins , Allison L. Zulli , Dandu R. Reddy , Diane E. Gingrich , Ming Tao , Nadine C. Becknell , James L. Diebold , Theodore L. Underiner
IPC分类号： A61K31/506 , A61K31/416 , A61K31/4162 , C07D231/54
CPC分类号： C07D487/14 , C07D487/04
摘要： The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
摘要翻译： 本发明一般涉及选择的稠合吡咯并唑，包括其药物组合物和用其治疗疾病的方法。 本发明还涉及制备这些稠合的吡咯并咔唑的中间体和方法。
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公开(公告)号：US08084472B2
公开(公告)日：2011-12-27
申请号：US12415525
申请日：2009-03-31
IPC分类号： A61K31/403
CPC分类号： C07D487/14 , C07D487/04 , C07D513/14 , C09B57/00 , C09B57/08
摘要： The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
摘要翻译： 本发明一般涉及选择的稠合吡咯并唑，包括其药物组合物和用其治疗疾病的方法。 本发明还涉及制备这些稠合的吡咯并咔唑的中间体和方法。
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公开(公告)号：US08471005B2
公开(公告)日：2013-06-25
申请号：US13160890
申请日：2011-06-15
申请人： Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
发明人： Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
IPC分类号： C07D487/04 , C07D403/12 , A61K31/53 , A61K31/5377 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides a compound of formula I or a salt form thereof, wherein Q1, Q2, Q3, and Q4 are as defined herein. The compound of formula I has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译： 本发明提供式I化合物或其盐形式，其中Q 1，Q 2，Q 3和Q 4如本文所定义。 式I化合物具有ALK和/或JAK2抑制活性，可用于治疗增殖性疾病。
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公开(公告)号：US20120028919A1
公开(公告)日：2012-02-02
申请号：US13160890
申请日：2011-06-15
申请人： Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
发明人： Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
IPC分类号： A61K31/5377 , C07D223/16 , A61P35/00 , A61K31/53 , A61K31/695 , C07D487/04 , A61K31/55
CPC分类号： C07D487/04
摘要： The present invention provides a compound of formula I or a salt form thereof, wherein Q1, Q2, Q3, and Q4 are as defined herein. The compound of formula I has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译： 本发明提供式I化合物或其盐形式，其中Q 1，Q 2，Q 3和Q 4如本文所定义。 式I化合物具有ALK和/或JAK2抑制活性，可用于治疗增殖性疾病。
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公开(公告)号：US07514440B2
公开(公告)日：2009-04-07
申请号：US11744030
申请日：2007-05-03
IPC分类号： A61K31/497 , C07D401/00
CPC分类号： C07D487/14 , C07D487/04 , C07D513/14 , C09B57/00 , C09B57/08
摘要： The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
摘要翻译： 本发明一般涉及选择的稠合吡咯并唑，包括其药物组合物和用其治疗疾病的方法。 本发明还涉及制备这些稠合的吡咯并咔唑的中间体和方法。
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公开(公告)号：US07241779B2
公开(公告)日：2007-07-10
申请号：US11017915
申请日：2004-12-22
IPC分类号： A61K31/403 , A61K31/4427 , A61K31/497 , A61K31/5355 , A61K31/416 , A61K31/4162 , C07D487/22
CPC分类号： C07D487/14 , C07D487/04 , C07D513/14 , C09B57/00 , C09B57/08
摘要： The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
摘要翻译： 本发明一般涉及选择的稠合吡咯并唑，包括其药物组合物和用其治疗疾病的方法。 本发明还涉及制备这些稠合的吡咯并咔唑的中间体和方法。
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