公开(公告)号：US20110057654A1

公开(公告)日：2011-03-10

申请号：US12919215

申请日：2009-02-25

申请人： Nan Sun ,  Donhee Ham

发明人： Nan Sun ,  Donhee Ham

IPC分类号： G01R33/44

CPC分类号： G01R33/3628 ,  G01R33/302 ,  G01R33/341 ,  G01R33/3607 ,  G01R33/3621

摘要： The Rabi frequency of oscillation of the nuclear magnetization vector of a sample in an NMR system may be controlled by modifying only the duty cycle of RF pulses delivered to the sample, without modifying the amplitude of the RF pulses, until the energy delivered at the Larmor frequency is adjusted to a desired amount. An impedance matching network between an NMR transceiver and an NMR coil may perform both power matching and noise matching simultaneously. During a transmission mode, the impedance matching network is connected to a transmitter portion of the transceiver, and the impedance of the coil is matched to the driver resistance. During a receiver mode, the impedance matching network is disconnected from the transmitter portion so that the impedance matching network remains connected only to the receiver portion, and signal-to-noise ratio in received NMR signals is maximized.

摘要翻译： NMR系统中样品的核磁化矢量的Rabi振荡频率可以通过仅修改传送到样品的RF脉冲的占空比而不修改RF脉冲的幅度来控制，直到在Larmor处传送的能量 频率被调整到期望的量。 NMR收发器和NMR线圈之间的阻抗匹配网络可以同时执行功率匹配和噪声匹配。 在传输模式期间，阻抗匹配网络连接到收发器的发射器部分，并且线圈的阻抗与驱动器电阻相匹配。 在接收器模式期间，阻抗匹配网络与发射机部分断开，使得阻抗匹配网络仅保持连接到接收机部分，并且接收的NMR信号中的信噪比最大化。

公开(公告)号：US08390489B2

公开(公告)日：2013-03-05

申请号：US12863441

申请日：2009-01-21

申请人： Nan Sun ,  Donhee Ham

发明人： Nan Sun ,  Donhee Ham

IPC分类号： H03M1/10

CPC分类号： H03M1/1014 ,  H03M1/1019

摘要： Digital background calibration in a pipelined ADC is performed by extracting a capacitor mismatch value Δ that represents a mismatch between a sampling capacitor C1 and a feedback capacitor C2 in the pipelined ADC, and using Δ to correct the capacitor mismatch error. Δ is extracted by performing commutated feedback capacitor switching (CFCS) in a background correlation loop. The error caused by the capacitor mismatch is calibrated out by subtracting the error from a digital output Dout of the pipelined ADC. Convergence speed may be accelerated and convergence accuracy may be increased during digital background calibration of pipelined ADCs, by using a higher order LPF. A bandwidth switching scheme may be implemented by the LPF, i.e. a larger bandwidth may be utilized during calibration start-up to increase convergence speed during start-up and a smaller bandwidth may be utilized during steady state to increase convergence accuracy during steady state.

摘要翻译： 流水线ADC中的数字背景校准通过提取电容器失配值＆Dgr来执行; 表示采样电容器C1和流水线ADC中的反馈电容器C2之间的不匹配，并且使用＆Dgr; 以纠正电容器失配误差。 ＆Dgr 通过在背景相关循环中执行换向反馈电容器切换（CFCS）来提取。 通过从流水线ADC的数字输出Dout中减去误差来校正由电容器失配引起的误差。 可以通过使用更高阶的LPF，在流水线ADC的数字背景校准期间可以加速收敛速度并且可以增加收敛精度。 带宽切换方案可以由LPF实现，即在校准启动期间可以利用较大的带宽以增加启动期间的收敛速度，并且可以在稳态期间利用较小的带宽以增加稳态期间的收敛精度。

公开(公告)号：US20110091987A1

公开(公告)日：2011-04-21

申请号：US12681303

申请日：2008-10-06

申请人： Ralph Weissleder ,  Hakho Lee ,  Donhee Ham ,  Nan Sun ,  Yong Liu

发明人： Ralph Weissleder ,  Hakho Lee ,  Donhee Ham ,  Nan Sun ,  Yong Liu

IPC分类号： G01N24/08 ,  B01J19/00

CPC分类号： G01R33/302 ,  G01R33/307 ,  G01R33/34092 ,  G01R33/383 ,  G01R33/465 ,  G01R33/50 ,  G01R33/5601 ,  G01R33/5617 ,  Y10T436/24

摘要： The present application describes devices, systems, and techniques related to a chip-based, miniaturized NMR diagnostic platform for rapid, quantitative and multi-channeled detection of biological targets.

摘要翻译： 本申请描述了与用于快速，定量和多通道检测生物靶标的基于芯片的小型化NMR诊断平台相关的装置，系统和技术。

公开(公告)号：US08643368B2

公开(公告)日：2014-02-04

申请号：US12919215

申请日：2009-02-25

申请人： Nan Sun ,  Donhee Ham

发明人： Nan Sun ,  Donhee Ham

IPC分类号： G01R33/44

CPC分类号： G01R33/3628 ,  G01R33/302 ,  G01R33/341 ,  G01R33/3607 ,  G01R33/3621

摘要： The Rabi frequency of oscillation of the nuclear magnetization vector of a sample in an NMR system may be controlled by modifying only the duty cycle of RF pulses delivered to the sample, without modifying the amplitude of the RF pulses, until the energy delivered at the Larmor frequency is adjusted to a desired amount. An impedance matching network between an NMR transceiver and an NMR coil may perform both power matching and noise matching simultaneously. During a transmission mode, the impedance matching network is connected to a transmitter portion of the transceiver, and the impedance of the coil is matched to the driver resistance. During a receiver mode, the impedance matching network is disconnected from the transmitter portion so that the impedance matching network remains connected only to the receiver portion, and signal-to-noise ratio in received NMR signals is maximized.

摘要翻译： NMR系统中样品的核磁化矢量的Rabi振荡频率可以通过仅修改传送到样品的RF脉冲的占空比而不修改RF脉冲的幅度来控制，直到在Larmor处传送的能量 频率被调整到期望的量。 NMR收发器和NMR线圈之间的阻抗匹配网络可以同时执行功率匹配和噪声匹配。 在传输模式期间，阻抗匹配网络连接到收发器的发射器部分，并且线圈的阻抗与驱动器电阻相匹配。 在接收器模式期间，阻抗匹配网络与发射机部分断开，使得阻抗匹配网络仅保持连接到接收机部分，并且接收的NMR信号中的信噪比最大化。

公开(公告)号：US20110043395A1

公开(公告)日：2011-02-24

申请号：US12863441

申请日：2009-01-21

申请人： Nan Sun ,  Donhee Ham

发明人： Nan Sun ,  Donhee Ham

IPC分类号： H03M1/10 ,  H03M1/12

CPC分类号： H03M1/1014 ,  H03M1/1019

摘要： Digital background calibration in a pipelined ADC is performed by extracting a capacitor mismatch value Δ that represents a mismatch between a sampling capacitor C1 and a feedback capacitor C2 in the pipelined ADC, and using Δ to correct the capacitor mismatch error. Δ is extracted by performing commutated feedback capacitor switching (CFCS) in a background correlation loop. The error caused by the capacitor mismatch is calibrated out by subtracting the error from a digital output Dout of the pipelined ADC. Convergence speed may be accelerated and convergence accuracy may be increased during digital background calibration of pipelined ADCs, by using a higher order LPF. A bandwidth switching scheme may be implemented by the LPF, i.e. a larger bandwidth may be utilized during calibration start-up to increase convergence speed during start-up and a smaller bandwidth may be utilized during steady state to increase convergence accuracy during steady state.

摘要翻译： 流水线ADC中的数字背景校准通过提取电容器失配值＆Dgr来执行; 表示采样电容器C1和流水线ADC中的反馈电容器C2之间的不匹配，并且使用＆Dgr; 以纠正电容器失配误差。 ＆Dgr 通过在背景相关循环中执行换向反馈电容器切换（CFCS）来提取。 通过从流水线ADC的数字输出Dout中减去误差来校正由电容器失配引起的误差。 可以通过使用更高阶的LPF，在流水线ADC的数字背景校准期间可以加速收敛速度并且可以增加收敛精度。 带宽切换方案可以由LPF实现，即在校准启动期间可以利用较大的带宽以增加启动期间的收敛速度，并且可以在稳态期间利用较小的带宽以增加稳态期间的收敛精度。

公开(公告)号：US20100006439A1

公开(公告)日：2010-01-14

申请号：US12559895

申请日：2009-09-15

申请人： Donhee Ham ,  Robert Westervelt ,  Thomas Hunt ,  Yong Liu ,  Hakho Lee

发明人： Donhee Ham ,  Robert Westervelt ,  Thomas Hunt ,  Yong Liu ,  Hakho Lee

IPC分类号： B03C5/02

CPC分类号： G01R33/302 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2200/147 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0877 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/043 ,  G01N15/1031 ,  G01N24/08 ,  G01N24/10 ,  G01R33/307 ,  G01R33/34092 ,  G01R33/3415 ,  G01R33/465 ,  G01R33/4808 ,  G01R33/5604

摘要： Methods and apparatus for manipulation, detection, imaging, characterization, sorting and/or assembly of biological or other materials, involving an integration of CMOS or other semiconductor-based technology and microfluidics. In one implementation, various components relating to the generation of electric and/or magnetic fields are implemented on an IC chip that is fabricated using standard protocols. The generated electric and/or magnetic fields are used to manipulate and/or detect one or more dielectric and/or magnetic particles and distinguish different types of particles. A microfluidic system is fabricated either directly on top of the IC chip, or as a separate entity that is then appropriately bonded to the IC chip, to facilitate the introduction and removal of cells in a biocompatible environment, or other particles/objects of interest suspended in a fluid. The patterned electric and/or magnetic fields generated by the IC chip can trap and move biological cells or other objects inside the microfluidic system. Electric and/or magnetic field generating components also may be controlled using signals of various frequencies so as to detect one or more cells, particles or objects of interest, and even the type of particle or object of interest, by measuring resonance characteristics associated with interactions between samples and one or more of the field-generating devices. Such systems may be employed in a variety of biological and medical related applications, including cell sorting and tissue assembly.

摘要翻译： 用于操作，检测，成像，表征，分选和/或组装生物或其他材料的方法和装置，涉及CMOS或其他基于半导体的技术和微流体的集成。 在一个实现中，与使用标准协议制造的IC芯片上实现与电场和/或磁场的产生有关的各种组件。 产生的电场和/或磁场用于操纵和/或检测一个或多个电介质和/或磁性颗粒并区分不同类型的颗粒。 微流体系统直接制造在IC芯片的顶部上，或者作为独立的实体，然后适当地结合到IC芯片，以便于在生物相容性环境或其他感兴趣的其它颗粒/物体中引入和去除细胞悬浮 在流体中。 由IC芯片产生的图案化电场和/或磁场可以捕获并移动微流体系统内的生物细胞或其它物体。 可以使用各种频率的信号来控制电场和/或磁场产生组件，以便通过测量与相互作用相关联的共振特性来检测一个或多个感兴趣的细胞，颗粒或感兴趣的物体，甚至是感兴趣的粒子或物体的类型 样本和一个或多个场产生装置之间。 这样的系统可以用于各种生物和医学相关应用，包括细胞分选和组织组装。

公开(公告)号：US20090315631A1

公开(公告)日：2009-12-24

申请号：US12083747

申请日：2006-10-30

申请人： Donhee Ham ,  Xiaofeng Li

发明人： Donhee Ham ,  Xiaofeng Li

IPC分类号： H03B5/18

CPC分类号： H01L51/0048 ,  B82Y10/00 ,  H01L21/31645 ,  H01L51/0541 ,  H03B5/1852

摘要： Methods and apparatus utilizing the quantum inductance of one-dimensional (ID) nanoscale structures (e.g., nanowires, carbon nanotubes). In one exemplary circuit implementation, all elements of a high-frequency circuit path are constituted by nanoscale structures without significant intervening structures (e.g., metal contacts) that would introduce undesirable resistance in the high-frequency circuit path. In this manner, the deleterious effects of contact resistance (e.g., metal-to-nanostructure interfaces) on the quality factor associated with the quantum inductance, and ultimately operation of the circuit, may be significantly reduced or avoided.

摘要翻译： 利用一维（ID）纳米尺度结构（例如纳米线，碳纳米管）的量子电感的方法和装置。 在一个示例性电路实现中，高频电路路径的所有元件由纳米尺度结构构成，而没有在高频电路路径中引入不期望的电阻的明显中间结构（例如金属触点）。 以这种方式，可以显着地减少或避免接触电阻（例如金属与纳米结构界面）对与量子电感相关的品质因素以及电路的最终操作的有害影响。

公开(公告)号：US20050068127A1

公开(公告)日：2005-03-31

申请号：US10894717

申请日：2004-07-19

申请人： Donhee Ham ,  William Andress ,  Yong Liu

发明人： Donhee Ham ,  William Andress ,  Yong Liu

IPC分类号： H01P3/00 ,  H01P3/08 ,  H01P5/02 ,  H03B5/18

CPC分类号： H01P3/026 ,  H01P5/02 ,  H03B5/1841 ,  H03B5/1852

摘要： Methods and apparatus involving semiconductor devices based on coplanar striplines (CPS). In one example, high-speed microelectronic devices based on coplanar stripline implementations support differential signals in a range of approximately from 1 Gigahertz to at least 60 Gigahertz. In one aspect, CPS-based devices incorporate various features that dramatically increase the quality factor Q of the resulting device. In another aspect, an enhancement of the quality factor Q is achieved while at the same time reducing the phase velocity of one or more waves propagating in the device, thereby also facilitating the fabrication of relatively smaller devices. In yet another aspect, a tapered coplanar stripline configuration results in position-dependent line parameters, which may be exploited to achieve significantly high-Q devices. Examples of CPS-based devices incorporating such features include impedance matching devices, devices for power combining and division, delays, resonators, oscillators, filters, amplifiers, mixers and the like, including CMOS-based implementations of such devices.

摘要翻译： 涉及基于共面带状线（CPS）的半导体器件的方法和装置。 在一个示例中，基于共面带状线实现的高速微电子器件支持在大约1千兆赫到至少60千兆赫的范围内的差分信号。 在一个方面，基于CPS的设备包含大大增加所得设备的质量因子Q的各种特征。 另一方面，实现质量因子Q的增强，同时降低在器件中传播的一个或多个波的相速度，从而也有助于制造相对较小的器件。 在另一方面，锥形共面带状线构造导致位置相关的线参数，其可被利用以实现显着的高Q器件。 包括这种特征的基于CPS的装置的例子包括阻抗匹配装置，用于功率组合和分割的装置，延迟，谐振器，振荡器，滤波器，放大器，混频器等，包括这种装置的基于CMOS的实现。

公开(公告)号：US20050068116A1

公开(公告)日：2005-03-31

申请号：US10894674

申请日：2004-07-19

申请人： Donhee Ham ,  William Andress ,  Yong Liu

发明人： Donhee Ham ,  William Andress ,  Yong Liu

IPC分类号： H01P3/00 ,  H01P3/08 ,  H01P5/02 ,  H03B5/18 ,  H01P5/00

CPC分类号： H01P3/026 ,  H01P5/02 ,  H03B5/1841 ,  H03B5/1852

摘要： Methods and apparatus for implementing standing wave oscillators (SWOS) using coplanar striplines (CPS). One example is given by a quarter-wavelength (λ/4) coplanar stripline standing wave oscillator (SWO), while another implementation utilizes a closed-loop coplanar stripline configuration. In various aspects, SWOs are configured to optimize sinusoidal performance at high frequencies with low power dissipation by incorporating various features that dramatically increase the quality factor Q of the oscillator. In particular, in one aspect, an amplitude-dependent tailored distributed amplification scheme is employed as a mode control technique using multiple amplifiers having different gains along the length of the coplanar stripline. In another aspect, a coplanar stripline configured such that its resistance per unit length R and conductance per unit length G are discreet or continuous functions of position along the coplanar stripline is employed to reduce SWO losses. In another aspect, an enhancement of the quality factor Q is achieved while at the same time reducing the phase velocity of waves propagating in the SWO, thereby also facilitating the fabrication of relatively smaller devices. In yet another aspect, SWOs are configured with frequency adjustability that is again optimized to reduce power dissipation while facilitating significant adjustments of oscillator frequency.

摘要翻译： 使用共面带状线（CPS）实现驻波振荡器（SWOS）的方法和装置。 一个例子由四分之一波长（λ/ 4）共面带状线驻波振荡器（SWO）给出，而另一个实施方案利用闭环共面带状线配置。 在各个方面，SWO被配置为通过结合各种特征来显着提高振荡器的品质因数Q来优化具有低功耗的高频下的正弦曲线性能。 特别地，在一个方面，采用幅度相关的定制分布放大方案作为使用具有沿着共面带状线长度的不同增益的多个放大器的模式控制技术。 在另一方面，构造为使得其每单位长度R的电阻和每单位长度G的电导的共面带状线被用于减小SWO损耗的沿着共面带状线的位置的谨慎或连续的功能。 另一方面，实现质量因子Q的增强，同时降低在SWO中传播的波的相速度，从而也有助于制造相对较小的装置。 在另一方面，SWO配置有频率可调整性，再次优化以降低功耗，同时有助于振荡器频率的显着调整。

公开(公告)号：US20100007426A1

公开(公告)日：2010-01-14

申请号：US11991577

申请日：2006-09-06

申请人： David Ricketts ,  Donhee Ham ,  Xiaofeng Li

发明人： David Ricketts ,  Donhee Ham ,  Xiaofeng Li

IPC分类号： H03B7/08

CPC分类号： H03L7/099 ,  H03B5/1221 ,  H03B5/1234 ,  H03B5/1243 ,  H03K5/12

摘要： Methods and apparatus for implementing stable self-starting and self-sustaining high-speed electrical nonlinear pulse (e.g., soliton, cnoidal wave, or quasi-soliton) oscillators. Chip-scale nonlinear pulse oscillator devices may be fabricated using III-V semiconductor materials (e.g., GaAs) to attain soliton pulse widths on the order of a few picoseconds or less (e.g., 1 to 2 picoseconds, corresponding to frequencies of approximately 300 GHz or greater). In one example, a nonlinear pulse oscillator is implemented as a closed loop structure that comprises a nonlinear transmission line and a distributed nonlinear amplifier arrangement configured to provide a self-adjusting gain as a function of an average voltage of the oscillator signal. In another example, a nonlinear oscillator employing a lumped nonlinear amplifier and a nonlinear transmission line in a closed loop arrangement may be used in combination with a two-port nonlinear transmission line that provides additional pulse compression for pulses circulating in the oscillator.

摘要翻译： 用于实现稳定的自启动和自持的高速电非线性脉冲（例如，孤子，cnoidal波或准孤子）振荡器的方法和装置。 可以使用III-V半导体材料（例如，GaAs）制造芯片级非线性脉冲振荡器器件，以获得大约几皮秒或更小的孤子脉冲宽度（例如，1到2皮秒，对应于大约300GHz的频率 或更大）。 在一个示例中，非线性脉冲振荡器被实现为闭环结构，其包括非线性传输线和配置为提供作为振荡器信号的平均电压的函数的自调节增益的分布式非线性放大器布置。 在另一示例中，采用集总非线性放大器和闭环布置中的非线性传输线的非线性振荡器可以与为在振荡器中循环的脉冲提供额外的脉冲压缩的双端口非线性传输线路组合使用。