公开(公告)号：US06583144B2

公开(公告)日：2003-06-24

申请号：US10127491

申请日：2002-04-23

申请人： Naoto Ohkura ,  Takashi Tsuruoka ,  Takayuki Usui ,  Yukiko Hiraiwa ,  Tetsuya Matsushima ,  Masaharu Shiotani ,  Tetsutaro Niizato ,  Yuuko Nakatani ,  Shigeki Suzuki ,  Chidsuko Kuroda ,  Kiyoaki Katano

发明人： Naoto Ohkura ,  Takashi Tsuruoka ,  Takayuki Usui ,  Yukiko Hiraiwa ,  Tetsuya Matsushima ,  Masaharu Shiotani ,  Tetsutaro Niizato ,  Yuuko Nakatani ,  Shigeki Suzuki ,  Chidsuko Kuroda ,  Kiyoaki Katano

IPC分类号： A61K31495

CPC分类号： C07D409/12 ,  C07D209/46 ,  C07D217/24 ,  C07D265/22 ,  C07D279/08 ,  G03F7/2049 ,  Y10S977/915

摘要： Disclosed are compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof. The compounds can inhibit the biosynthesis of triglycerides in the liver and can inhibit the secretion of lipoprotein containing apolipoprotein B from the liver. Therefore, they are useful for the prevention or treatment of hyperlipidemia (particularly hyper-very-low-density-lipoproteinemia) and arteriosclerotic diseases, such as cardiac infarction, or pancreatitis induced by hyperlipidemia. wherein A represents group —CR1R2—(CH2)i— where R1 and R2 each represent a hydrogen atom or alkyl, —CH═CH—, —O—CH2—, or —S(O)j—CH2—; B represents a hydrogen or halogen atom; X represents —CR3R4R5, —NR6R7, —(CH2—CH═C(CH3)—CH2)p—CH2CH═C(CH3)2, alkyl, cycloalkyl, phenyl, cinnamyl, or heteroaromatic ring; Y represents —(CH2)q—, —CH═CH—, —NR8—, an oxygen atom, or a bond; Z represents carbonyl or a bond; K represents alkylene or a bond; L represents —CH═CH— or a bond; and M represents a hydrogen atom, alkyl, cycloalkyl, phenyl, heterocyclic ring, biphenyl, or diphenylmethyl.

摘要翻译： 公开了由式（I）表示的化合物及其药学上可接受的盐和溶剂化物。 该化合物可以抑制肝脏中甘油三酯的生物合成，并可以抑制含有载脂蛋白B的脂蛋白从肝脏的分泌。 因此，它们可用于预防或治疗由高脂血症引起的高脂血症（特别是超低密度脂蛋白血症）和动脉硬化疾病如心肌梗死或胰腺炎。其中A代表基团-CR1R2-（CH2）i - 其中R1和R2各自表示氢原子或烷基，-CH = CH-，-O-CH2-或-S（O）j-CH2-; B表示氢或卤素原子; X代表-CR3R4R5，-NR6R7， - （CH2-CH = C（CH3）-CH2）p-CH2CH = C（CH3）2，烷基，环烷基，苯基，肉桂基或杂芳族环; Y表示 - （CH 2）q - ， - CH = CH - ， - NR 8 - ，氧原子或键; Z表示羰基或键; K表示亚烷基或键; L表示-CH = CH-或键; M代表氢原子，烷基，环烷基，苯基，杂环，联苯基或二苯基甲基。

公开(公告)号：US06417362B1

公开(公告)日：2002-07-09

申请号：US09424708

申请日：1999-11-30

申请人： Naoto Ohkura ,  Takashi Tsuruoka ,  Takayuki Usui ,  Yukiko Hiraiwa ,  Tetsuya Matsushima ,  Masaharu Shiotani ,  Tetsutaro Niizato ,  Yuuko Nakatani ,  Shigeki Suzuki ,  Chidsuko Kuroda ,  Kiyoaki Katano

发明人： Naoto Ohkura ,  Takashi Tsuruoka ,  Takayuki Usui ,  Yukiko Hiraiwa ,  Tetsuya Matsushima ,  Masaharu Shiotani ,  Tetsutaro Niizato ,  Yuuko Nakatani ,  Shigeki Suzuki ,  Chidsuko Kuroda ,  Kiyoaki Katano

IPC分类号： C07D24104

CPC分类号： C07D409/12 ,  C07D209/46 ,  C07D217/24 ,  C07D265/22 ,  C07D279/08 ,  G03F7/2049 ,  Y10S977/915

摘要： Disclosed are compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof. The compounds can inhibit the biosynthesis of triglycerides in the liver and can inhibit the secretion of lipoprotein containing apolipoprotein B from the liver. Therefore, they are useful for the prevention or treatment of hyperlipidemia (particularly hyper-very-low-density-lipoproteinemia) and arteriosclerotic diseases, such as cardiac infarction, or pancreatitis induced by hyperlipidemia. wherein A represents group —CR1R2—(CH2)i— where R1 and R2 each represent a hydrogen atom or alkyl, —CH═CH—, —O—CH2—, or —S(O)j—CH2—; B represents a hydrogen or halogen atom; X represents —CR3R4R5, —NR6R7, —(CH2—CH═C(CH3)—CH2)p—CH2CH═C(CH3)2, alkyl, cycloalkyl, phenyl, cinnamyl, or heteroaromatic ring; Y represents —(CH2)q—, —CH═CH—, —NR8—, an oxygen atom, or a bond; Z represents carbonyl or a bond; K represents alkylene or a bond; L represents —CH═CH— or a bond; and M represents a hydrogen atom, alkyl, cycloalkyl, phenyl, heterocyclic ring, biphenyl, or diphenylmethyl.

摘要翻译： 公开了由式（I）表示的化合物及其药学上可接受的盐和溶剂化物。 该化合物可以抑制肝脏中甘油三酯的生物合成，并可以抑制含有载脂蛋白B的脂蛋白从肝脏的分泌。 因此，它们可用于预防或治疗由高脂血症引起的高脂血症（特别是超低密度脂蛋白血症）和动脉硬化疾病如心肌梗死或胰腺炎。其中A代表基团-CR1R2-（CH2）i - 其中R1和R2各自表示氢原子或烷基，-CH = CH-，-O-CH2-或-S（O）j-CH2-; B表示氢或卤素原子; X代表-CR3R4R5，-NR6R7， - （CH2-CH = C（CH3）-CH2）p-CH2CH = C（CH3）2，烷基，环烷基，苯基，肉桂基或杂芳族环; Y表示 - （CH 2）q - ， - CH = CH - ， - NR 8 - ，氧原子或键; Z表示羰基或键; K表示亚烷基或键; L表示-CH = CH-或键; M代表氢原子，烷基，环烷基，苯基，杂环，联苯基或二苯基甲基。

公开(公告)号：US06777414B1

公开(公告)日：2004-08-17

申请号：US09958296

申请日：2001-10-05

申请人： Naoto Ohkura ,  Yukiko Hiraiwa ,  Tetsuya Matsushima ,  Kazue Sasaki ,  Takehiro Yamamoto ,  Masaharu Shiotani ,  Shigeki Suzuki ,  Yuuko Nakatani ,  Chizuko Kuroda ,  Mieko Nagasawa ,  Kiyoaki Katano

发明人： Naoto Ohkura ,  Yukiko Hiraiwa ,  Tetsuya Matsushima ,  Kazue Sasaki ,  Takehiro Yamamoto ,  Masaharu Shiotani ,  Shigeki Suzuki ,  Yuuko Nakatani ,  Chizuko Kuroda ,  Mieko Nagasawa ,  Kiyoaki Katano

IPC分类号： C07D20946

CPC分类号： C07D213/40 ,  C07D209/46 ,  C07D295/155 ,  C07D309/04 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D471/04

摘要： Disclosed are compounds represented by formula (I) which have triglyceride biosynthesis inhibitory activity in the liver and inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein from the liver and particularly have excellent inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein, are free from side effect of accumulation of lipids in the liver, and are useful for the treatment and prevention of hyperlipidemia and arteriosclerotic diseases. In formula (I), R1 and R2 represent alkyl, alkoxy, cycloalkyl, phenyl, alkenyl, alkynyl, or a five- or six-membered saturated or unsaturated heterocyclic ring, or R1 and R2, together with a nitrogen atom to which R1 and R2 are attached, may form a ring; R3 and R4 represent a hydrogen atom, alkyl, a halogen atom, hydroxyl, nitrile, alkoxycarbonyl, alkoxy, or carboxyl; or R2 and R3 may be attached to each other to form —(CH2)m—, —N═CH—, —CH═N—, or —(C1-6 alkyl)C═N—; A, D, E, and G each represent a carbon atom, or any one of A, D, E, and G represents a nitrogen atom with the other three each representing a carbon atom; Q represents a nitrogen atom or a carbon atom; Y represents a group represented by formula (II) wherein X represents a hydrogen atom, group —C(═O)N(R5)R6 or group —C(═O)OR7, R8 is absent or represents a bond, an oxygen atom, a sulfur atom, —SO2—, —SO—, —CH2—CH2—, or —CH═CH—, and R9 and R10 represent a hydrogen atom, alkyl, alkoxy, a halogen atom, or hydroxyl; and Z represents —(CH2)n—, —O—(CH2)i—, or —C(═O)NH—(CH2)i—.

摘要翻译： 公开了在肝脏中具有甘油三酯生物合成抑制活性的由式​​（I）表示的化合物，并且对来自肝脏的含载脂蛋白B的脂蛋白的分泌具有抑制活性，特别是对含有载脂蛋白B的脂蛋白的分泌具有优异的抑制活性。 没有肝脏中脂质积累的副作用，可用于治疗和预防高脂血症和动脉硬化性疾病。 在式（I）中，R 1和R 2表示烷基，烷氧基，环烷基，苯基，烯基，炔基或五元或六元饱和或不饱和杂环，或R 1和R 2， 2>与R 1和R 2连接的氮原子一起形成环; R 3和R 4表示氢原子，烷基，卤素原子，羟基，腈，烷氧基羰基，烷氧基或羧基; 或R 2和R 3可以彼此连接形成 - （CH 2）m - ， - N = CH - ， - CH = N-或 - （C 1-6烷基）C = N-; A，D，E和G各自表示碳原子，A，D，E和G中的任一个表示氮原子，其余三个表示碳原子; Q表示氮原子或碳原子; Y表示由式（II）表示的基团，其中X表示氢原子，-C（= O）N（R 5）R 6或-C（= O）OR 7， 8>不存在或表示键，氧原子，硫原子，-SO 2 - ， - SO - ， - CH 2 -CH 2 - 或-CH = CH-，R 9和R 10表示 氢原子，烷基，烷氧基，卤素原子或羟基; 并且Z表示 - （CH 2）n - ， - O-（CH 2）i - 或-C（= O）NH-（CH 2）i - 。

公开(公告)号：US07030120B2

公开(公告)日：2006-04-18

申请号：US10868006

申请日：2004-06-16

申请人： Naoto Ohkura ,  Yukiko Hiraiwa ,  Tetsuya Matsushima ,  Kazue Sasaki ,  Takehiro Yamamoto ,  Masaharu Shiotani ,  Shigeki Suzuki ,  Yuuko Nakatani ,  Chizuko Kuroda ,  Mieko Nagasawa ,  Kiyoaki Katano

发明人： Naoto Ohkura ,  Yukiko Hiraiwa ,  Tetsuya Matsushima ,  Kazue Sasaki ,  Takehiro Yamamoto ,  Masaharu Shiotani ,  Shigeki Suzuki ,  Yuuko Nakatani ,  Chizuko Kuroda ,  Mieko Nagasawa ,  Kiyoaki Katano

IPC分类号： C07D209/46 ,  C07D213/81 ,  C07D213/82 ,  C07D217/22 ,  C07D237/30

CPC分类号： C07D213/40 ,  C07D209/46 ,  C07D295/155 ,  C07D309/04 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D471/04

摘要： Disclosed are compounds represented by formula (I) which have triglyceride biosynthesis inhibitory activity in the liver and inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein from the liver and particularly have excellent inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein, are free from side effect of accumulation of lipids in the liver, and are useful for the treatment and prevention of hyperlipidemia and arteriosclerotic diseases. In formula (I), R1 and R2 represent alkyl, alkoxy, cycloalkyl, phenyl, alkenyl, alkynyl, or a five- or six-membered saturated or unsaturated heterocyclic ring, or R1 and R2, together with a nitrogen atom to which R1 and R2 are attached, may form a ring; R3 and R4 represent a hydrogen atom, alkyl, a halogen atom, hydroxyl, nitrile, alkoxycarbonyl, alkoxy, or carboxyl; or R2 and R3 may be attached to each other to form —(CH2)m—, —N═CH—, —CH═N—, or —(C1-6 alkyl)C═N—; A, D, E, and G each represent a carbon atom, or any one of A, D, E, and G represents a nitrogen atom with the other three each representing a carbon atom; Q represents a nitrogen atom or a carbon atom; Y represents a group represented by formula (II) wherein X represents a hydrogen atom, group —C(═O)N(R5)R6 or group —C(═O)OR7, R8 is absent or represents a bond, an oxygen atom, a sulfur atom, —SO2—, —SO—, —CH2—CH2—, or —CH═CH—, and R9 and R10 represent a hydrogen atom, alkyl, alkoxy, a halogen atom, or hydroxyl; and Z represents —(CH2)n—, —O—(CH2)i—, or —C(═O)NH—(CH2)i—

公开(公告)号：US08596761B2

公开(公告)日：2013-12-03

申请号：US13413622

申请日：2012-03-06

申请人： Hiroyuki Kobayashi ,  Hiroshige Owaki ,  Shigeki Suzuki

发明人： Hiroyuki Kobayashi ,  Hiroshige Owaki ,  Shigeki Suzuki

IPC分类号： B41J2/14

CPC分类号： B41J2/155 ,  B41J2/14233 ,  B41J2/1433 ,  B41J2002/14362 ,  B41J2202/19 ,  B41J2202/20 ,  Y10T29/49401

摘要： A liquid ejecting head includes head main bodies each having a nozzle plate having nozzle openings, and a case member to which the head main bodies are fixed, and moves relatively in a first direction with respect to a recording sheet, wherein a cover head which covers the side surfaces of the head main body and a peripheral border of the nozzle plate is provided at each head main body, a protective wall is provided for each head main body between an end portion in the first direction of the case member and the head main body, a range in a second direction of the cover head is included in a range in the second direction of the protective wall, and the protective wall is located further on the case member side than the nozzle plate in a third direction.

摘要翻译： 一种液体喷射头，包括：头主体，每个头主体具有喷嘴板，喷嘴板具有喷嘴开口;以及壳体部件，头部主体固定在该壳体部件上，并相对于记录纸沿第一方向相对移动， 头主体的侧面和喷嘴板的周边设置在每个头主体上，在壳体部件的第一方向的端部与头部主体之间，为每个头主体设置保护壁 盖头的第二方向上的范围包括在保护壁的第二方向上的范围内，并且保护壁在第三方向上比喷嘴板更进一步位于壳体构件侧。

公开(公告)号：US08572557B2

公开(公告)日：2013-10-29

申请号：US13195073

申请日：2011-08-01

申请人： Takahiro Ito ,  Shigeki Suzuki ,  Yoshiko Ochiai ,  Noriyuki Kushiro ,  Yoshiaki Koizumi

发明人： Takahiro Ito ,  Shigeki Suzuki ,  Yoshiko Ochiai ,  Noriyuki Kushiro ,  Yoshiaki Koizumi

IPC分类号： G06F9/44

CPC分类号： G06F8/4434

摘要： To obtain a program code generation support device, method, and the like, capable of generating a new program code, in particular, generating in accordance with an incorporating apparatus, by performing a further optimization on a program code. The device includes storage means for storing as data, an optimization rule that is composed of a conversion condition for converting data of a program code and a conversion content thereof, and code optimization means that includes a code analysis unit for analyzing the program code, a condition search unit for search a part matching the conversion condition in the program code through a collation with the optimization rule stored in the storage means on the basis of the analyzed program code, and an optimization unit for generating data of a new program code by converting the part matching the conversion condition on the basis of the conversion content.

摘要翻译： 为了获得程序代码生成支持设备，方法等，能够通过对程序代码进行进一步的优化，特别地，根据并入设备生成新的程序代码。 该装置包括用于存储数据的存储装置，由用于转换程序代码的数据的转换条件及其转换内容组成的优化规则，以及包括用于分析程序代码的代码分析单元的代码优化装置， 条件搜索单元，用于基于所分析的程序代码，通过与存储在存储装置中的优化规则对照来搜索与程序代码中的转换条件相匹配的部分;以及优化单元，用于通过转换来生成新程序代码的数据 基于转换内容匹配转换条件的部分。

公开(公告)号：US08448158B2

公开(公告)日：2013-05-21

申请号：US11883627

申请日：2006-02-02

申请人： Takahiro Ito ,  Shigeki Suzuki ,  Yoshiko Ochiai ,  Noriyuki Kushiro ,  Yoshiaki Koizumi

发明人： Takahiro Ito ,  Shigeki Suzuki ,  Yoshiko Ochiai ,  Noriyuki Kushiro ,  Yoshiaki Koizumi

IPC分类号： G06F9/45

CPC分类号： G06F8/443

摘要： To obtain a program code generation support device, method, and the like, capable of generating a new program code, in particular, generating in accordance with an incorporating apparatus, by performing a further optimization on a program code.The device includes storage means 6 for storing as data, an optimization rule that is composed of a conversion condition for converting data of a program code and a conversion content thereof, and code optimization means 4 that includes a code analysis unit 4A for analyzing the program code, a condition search unit 4B for search a part matching the conversion condition in the program code through a collation with the optimization rule stored in the storage means on the basis of the analyzed program code, and an optimization unit 4C for generating data of a new program code by converting the part matching the conversion condition on the basis of the conversion content.

摘要翻译： 为了获得程序代码生成支持设备，方法等，能够通过对程序代码进行进一步的优化，特别地，根据并入设备生成新的程序代码。 该装置包括用于存储数据的存储装置6，由用于转换程序代码的数据的转换条件及其转换内容组成的优化规则，以及包括用于分析程序的代码分析单元4A的代码优化装置4 代码，条件搜索单元4B，用于基于分析的程序代码，通过与存储在存储装置中的优化规则对照来搜索与程序代码中的转换条件相匹配的部分;以及优化单元4C，用于生成 通过基于转换内容转换与转换条件匹配的部分的新程序代码。

公开(公告)号：US20120229568A1

公开(公告)日：2012-09-13

申请号：US13417126

申请日：2012-03-09

申请人： Shigeki Suzuki ,  Hiroshige Owaki ,  Hiroyuki Kobayashi ,  Hiroyuki Ishii

发明人： Shigeki Suzuki ,  Hiroshige Owaki ,  Hiroyuki Kobayashi ,  Hiroyuki Ishii

IPC分类号： B41J2/135

CPC分类号： B41J2/155 ,  B41J29/02 ,  B41J2202/20

摘要： A liquid ejection head includes a head main body which discharges liquid, a flow path member main body on which a liquid reception member for receiving liquid supplied from the outside is formed, a first case, a second case, and a first insertion portion which is provided on the flow path member main body and through which a securing member for securing the first case, the second case, and the flow path member main body to one another is inserted. In the liquid ejection head, the first insertion portion is formed such that the outer wall covers an exposing portion from which the securing member is exposed.

摘要翻译： 液体喷射头包括排出液体的头主体，形成有用于接收从外部供应的液体的液体接收构件的流路构件主体，第一壳体，第二壳体和第一插入部分， 设置在流路构件主体上并且插入用于将第一壳体，第二壳体和流路构件主体彼此固定的固定构件。 在液体喷射头中，第一插入部分形成为使得外壁覆盖暴露部分，固定部件从该露出部分露出。

公开(公告)号：US08231205B2

公开(公告)日：2012-07-31

申请号：US12047611

申请日：2008-03-13

申请人： Shigeki Suzuki

发明人： Shigeki Suzuki

IPC分类号： B41J2/045 ,  B41J2/165

CPC分类号： B41J2/14274 ,  B41J2202/07

摘要： A fluid ejecting head includes a fluid storage chamber that temporarily stores a fluid, which is supplied from a fluid supply port, a plurality of pressure chambers, to which the fluid stored in the fluid storage chamber is supplied through a plurality of fluid supply paths, respectively, a plurality of driving elements that change pressure in the pressure chambers, respectively, and a plurality of nozzle openings, from which the fluids contained in the pressure chambers are ejected when the driving elements are driven, respectively. A specific driving element most distant from the fluid supply port among the driving elements has a maximum capability to discharge the air bubbles in the fluid from the nozzle opening among the driving elements.

摘要翻译： 流体喷射头包括：液体储存室，其临时存储从流体供给口供给的流体，多个压力室，通过多个流体供给路径供给储存在流体容纳室中的流体， 分别改变压力室中的压力的​​多个驱动元件和分别在驱动元件被驱动时喷射包含在压力室中的流体的多个喷嘴开口。 驱动元件中最靠近流体供给口的特定驱动元件具有从驱动元件中的喷嘴开口排出流体中的气泡的最大能力。

公开(公告)号：US20120123542A1

公开(公告)日：2012-05-17

申请号：US13386032

申请日：2010-07-22

申请人： Shigeki Suzuki ,  Yuichi Tei ,  Nobuo Sasaki ,  Jianmei He

发明人： Shigeki Suzuki ,  Yuichi Tei ,  Nobuo Sasaki ,  Jianmei He

IPC分类号： A61F2/28

CPC分类号： A61F2/28 ,  A61F2002/30143 ,  A61F2002/30156 ,  A61F2002/30158 ,  A61F2002/3038 ,  A61F2002/30448 ,  A61F2002/30604 ,  A61F2002/30784 ,  A61F2002/3082

摘要： Provided are an artificial bone constructing unit which is capable of being built into a free shape according to build-up design, and effectively guiding bone replacement, and an artificial bone system. Specifically disclosed are an artificial bone constructing unit and an artificial bone constructing system, wherein in principal, the artificial bone constructing unit which constructs an artificial bone is so made into a block shape that when blocks are assembled, continuous holes through a plurality of blocks are formed.

摘要翻译： 提供一种人造骨构造单元，其能够根据积聚设计被自由形状，并且有效地引导骨置换，以及人造骨系统。 具体公开了一种人造骨构造单元和人造骨构造系统，其中，构成人造骨的人造骨构造单元的原理是将其制成块状，当块组装时，通过多个块的连续孔为 形成。