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12 条记录 (耗时 0.046 秒)

    Nitrogen-containing heterocyclic compounds and therapeutic agents for hyperlipidemia comprising the same
    1.
    发明授权
    Nitrogen-containing heterocyclic compounds and therapeutic agents for hyperlipidemia comprising the same 失效
    含氮杂环化合物和包含其的高脂血症治疗剂

    公开(公告)号：US06583144B2

    公开(公告)日：2003-06-24

    申请号：US10127491

    申请日：2002-04-23

    申请人： Naoto Ohkura ,  Takashi Tsuruoka ,  Takayuki Usui ,  Yukiko Hiraiwa ,  Tetsuya Matsushima ,  Masaharu Shiotani ,  Tetsutaro Niizato ,  Yuuko Nakatani ,  Shigeki Suzuki ,  Chidsuko Kuroda ,  Kiyoaki Katano

    发明人： Naoto Ohkura ,  Takashi Tsuruoka ,  Takayuki Usui ,  Yukiko Hiraiwa ,  Tetsuya Matsushima ,  Masaharu Shiotani ,  Tetsutaro Niizato ,  Yuuko Nakatani ,  Shigeki Suzuki ,  Chidsuko Kuroda ,  Kiyoaki Katano

    IPC分类号： A61K31495

    CPC分类号： C07D409/12 ,  C07D209/46 ,  C07D217/24 ,  C07D265/22 ,  C07D279/08 ,  G03F7/2049 ,  Y10S977/915

    摘要： Disclosed are compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof. The compounds can inhibit the biosynthesis of triglycerides in the liver and can inhibit the secretion of lipoprotein containing apolipoprotein B from the liver. Therefore, they are useful for the prevention or treatment of hyperlipidemia (particularly hyper-very-low-density-lipoproteinemia) and arteriosclerotic diseases, such as cardiac infarction, or pancreatitis induced by hyperlipidemia. wherein A represents group —CR1R2—(CH2)i— where R1 and R2 each represent a hydrogen atom or alkyl, —CH═CH—, —O—CH2—, or —S(O)j—CH2—; B represents a hydrogen or halogen atom; X represents —CR3R4R5, —NR6R7, —(CH2—CH═C(CH3)—CH2)p—CH2CH═C(CH3)2, alkyl, cycloalkyl, phenyl, cinnamyl, or heteroaromatic ring; Y represents —(CH2)q—, —CH═CH—, —NR8—, an oxygen atom, or a bond; Z represents carbonyl or a bond; K represents alkylene or a bond; L represents —CH═CH— or a bond; and M represents a hydrogen atom, alkyl, cycloalkyl, phenyl, heterocyclic ring, biphenyl, or diphenylmethyl.

    摘要翻译： 公开了由式（I）表示的化合物及其药学上可接受的盐和溶剂化物。 该化合物可以抑制肝脏中甘油三酯的生物合成，并可以抑制含有载脂蛋白B的脂蛋白从肝脏的分泌。 因此，它们可用于预防或治疗由高脂血症引起的高脂血症（特别是超低密度脂蛋白血症）和动脉硬化疾病如心肌梗死或胰腺炎。其中A代表基团-CR1R2-（CH2）i - 其中R1和R2各自表示氢原子或烷基，-CH = CH-，-O-CH2-或-S（O）j-CH2-; B表示氢或卤素原子; X代表-CR3R4R5，-NR6R7， - （CH2-CH = C（CH3）-CH2）p-CH2CH = C（CH3）2，烷基，环烷基，苯基，肉桂基或杂芳族环; Y表示 - （CH 2）q - ， - CH = CH - ， - NR 8 - ，氧原子或键; Z表示羰基或键; K表示亚烷基或键; L表示-CH = CH-或键; M代表氢原子，烷基，环烷基，苯基，杂环，联苯基或二苯基甲基。

    Nitrogenous heterocyclic compounds and hyperlipemia remedy containing the same
    2.
    发明授权
    Nitrogenous heterocyclic compounds and hyperlipemia remedy containing the same 失效
    含氮杂环化合物和含有相同的高脂血症药物

    公开(公告)号：US06417362B1

    公开(公告)日：2002-07-09

    申请号：US09424708

    申请日：1999-11-30

    申请人： Naoto Ohkura ,  Takashi Tsuruoka ,  Takayuki Usui ,  Yukiko Hiraiwa ,  Tetsuya Matsushima ,  Masaharu Shiotani ,  Tetsutaro Niizato ,  Yuuko Nakatani ,  Shigeki Suzuki ,  Chidsuko Kuroda ,  Kiyoaki Katano

    发明人： Naoto Ohkura ,  Takashi Tsuruoka ,  Takayuki Usui ,  Yukiko Hiraiwa ,  Tetsuya Matsushima ,  Masaharu Shiotani ,  Tetsutaro Niizato ,  Yuuko Nakatani ,  Shigeki Suzuki ,  Chidsuko Kuroda ,  Kiyoaki Katano

    IPC分类号： C07D24104

    CPC分类号： C07D409/12 ,  C07D209/46 ,  C07D217/24 ,  C07D265/22 ,  C07D279/08 ,  G03F7/2049 ,  Y10S977/915

    摘要： Disclosed are compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof. The compounds can inhibit the biosynthesis of triglycerides in the liver and can inhibit the secretion of lipoprotein containing apolipoprotein B from the liver. Therefore, they are useful for the prevention or treatment of hyperlipidemia (particularly hyper-very-low-density-lipoproteinemia) and arteriosclerotic diseases, such as cardiac infarction, or pancreatitis induced by hyperlipidemia. wherein A represents group —CR1R2—(CH2)i— where R1 and R2 each represent a hydrogen atom or alkyl, —CH═CH—, —O—CH2—, or —S(O)j—CH2—; B represents a hydrogen or halogen atom; X represents —CR3R4R5, —NR6R7, —(CH2—CH═C(CH3)—CH2)p—CH2CH═C(CH3)2, alkyl, cycloalkyl, phenyl, cinnamyl, or heteroaromatic ring; Y represents —(CH2)q—, —CH═CH—, —NR8—, an oxygen atom, or a bond; Z represents carbonyl or a bond; K represents alkylene or a bond; L represents —CH═CH— or a bond; and M represents a hydrogen atom, alkyl, cycloalkyl, phenyl, heterocyclic ring, biphenyl, or diphenylmethyl.

    摘要翻译： 公开了由式（I）表示的化合物及其药学上可接受的盐和溶剂化物。 该化合物可以抑制肝脏中甘油三酯的生物合成，并可以抑制含有载脂蛋白B的脂蛋白从肝脏的分泌。 因此，它们可用于预防或治疗由高脂血症引起的高脂血症（特别是超低密度脂蛋白血症）和动脉硬化疾病如心肌梗死或胰腺炎。其中A代表基团-CR1R2-（CH2）i - 其中R1和R2各自表示氢原子或烷基，-CH = CH-，-O-CH2-或-S（O）j-CH2-; B表示氢或卤素原子; X代表-CR3R4R5，-NR6R7， - （CH2-CH = C（CH3）-CH2）p-CH2CH = C（CH3）2，烷基，环烷基，苯基，肉桂基或杂芳族环; Y表示 - （CH 2）q - ， - CH = CH - ， - NR 8 - ，氧原子或键; Z表示羰基或键; K表示亚烷基或键; L表示-CH = CH-或键; M代表氢原子，烷基，环烷基，苯基，杂环，联苯基或二苯基甲基。

    Nitrogen-containing heterocyclic compounds and benamide compounds and drugs containing the same
    3.
    发明授权
    Nitrogen-containing heterocyclic compounds and benamide compounds and drugs containing the same 失效
    含氮杂环化合物和苯甲酰胺化合物及含有其的药物

    公开(公告)号：US06777414B1

    公开(公告)日：2004-08-17

    申请号：US09958296

    申请日：2001-10-05

    申请人： Naoto Ohkura ,  Yukiko Hiraiwa ,  Tetsuya Matsushima ,  Kazue Sasaki ,  Takehiro Yamamoto ,  Masaharu Shiotani ,  Shigeki Suzuki ,  Yuuko Nakatani ,  Chizuko Kuroda ,  Mieko Nagasawa ,  Kiyoaki Katano

    发明人： Naoto Ohkura ,  Yukiko Hiraiwa ,  Tetsuya Matsushima ,  Kazue Sasaki ,  Takehiro Yamamoto ,  Masaharu Shiotani ,  Shigeki Suzuki ,  Yuuko Nakatani ,  Chizuko Kuroda ,  Mieko Nagasawa ,  Kiyoaki Katano

    IPC分类号： C07D20946

    CPC分类号： C07D213/40 ,  C07D209/46 ,  C07D295/155 ,  C07D309/04 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D471/04

    摘要： Disclosed are compounds represented by formula (I) which have triglyceride biosynthesis inhibitory activity in the liver and inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein from the liver and particularly have excellent inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein, are free from side effect of accumulation of lipids in the liver, and are useful for the treatment and prevention of hyperlipidemia and arteriosclerotic diseases. In formula (I), R1 and R2 represent alkyl, alkoxy, cycloalkyl, phenyl, alkenyl, alkynyl, or a five- or six-membered saturated or unsaturated heterocyclic ring, or R1 and R2, together with a nitrogen atom to which R1 and R2 are attached, may form a ring; R3 and R4 represent a hydrogen atom, alkyl, a halogen atom, hydroxyl, nitrile, alkoxycarbonyl, alkoxy, or carboxyl; or R2 and R3 may be attached to each other to form —(CH2)m—, —N═CH—, —CH═N—, or —(C1-6 alkyl)C═N—; A, D, E, and G each represent a carbon atom, or any one of A, D, E, and G represents a nitrogen atom with the other three each representing a carbon atom; Q represents a nitrogen atom or a carbon atom; Y represents a group represented by formula (II) wherein X represents a hydrogen atom, group —C(═O)N(R5)R6 or group —C(═O)OR7, R8 is absent or represents a bond, an oxygen atom, a sulfur atom, —SO2—, —SO—, —CH2—CH2—, or —CH═CH—, and R9 and R10 represent a hydrogen atom, alkyl, alkoxy, a halogen atom, or hydroxyl; and Z represents —(CH2)n—, —O—(CH2)i—, or —C(═O)NH—(CH2)i—.

    摘要翻译： 公开了在肝脏中具有甘油三酯生物合成抑制活性的由式​​（I）表示的化合物，并且对来自肝脏的含载脂蛋白B的脂蛋白的分泌具有抑制活性，特别是对含有载脂蛋白B的脂蛋白的分泌具有优异的抑制活性。 没有肝脏中脂质积累的副作用，可用于治疗和预防高脂血症和动脉硬化性疾病。 在式（I）中，R 1和R 2表示烷基，烷氧基，环烷基，苯基，烯基，炔基或五元或六元饱和或不饱和杂环，或R 1和R 2， 2>与R 1和R 2连接的氮原子一起形成环; R 3和R 4表示氢原子，烷基，卤素原子，羟基，腈，烷氧基羰基，烷氧基或羧基; 或R 2和R 3可以彼此连接形成 - （CH 2）m - ， - N = CH - ， - CH = N-或 - （C 1-6烷基）C = N-; A，D，E和G各自表示碳原子，A，D，E和G中的任一个表示氮原子，其余三个表示碳原子; Q表示氮原子或碳原子; Y表示由式（II）表示的基团，其中X表示氢原子，-C（= O）N（R 5）R 6或-C（= O）OR 7， 8>不存在或表示键，氧原子，硫原子，-SO 2 - ， - SO - ， - CH 2 -CH 2 - 或-CH = CH-，R 9和R 10表示 氢原子，烷基，烷氧基，卤素原子或羟基; 并且Z表示 - （CH 2）n - ， - O-（CH 2）i - 或-C（= O）NH-（CH 2）i - 。