Antithrombogenic synthetic elastomer and process of preparation thereof
    2.
    发明授权
    Antithrombogenic synthetic elastomer and process of preparation thereof 失效
    抗血栓性合成弹性体及其制备方法

    公开(公告)号:US4687831A

    公开(公告)日:1987-08-18

    申请号:US852656

    申请日:1986-04-16

    摘要: Antithrombogenic synthetic elastomer having repeat units comprising portion I which is a soft segment unit containing a polyether and portion II which is a hard segment unit: ##STR1## R is a straight-chain or branched-chain alkylene group containing 2 to 4 carbon atoms, R' is amide a urethane, an urea, n ranges up to 180, m is an integer of 1 to 20, l is an integer of 1 to 10, said polymer having a microdomain structure composed of soft and hard segments, the domains of which have an average size of 10 to 20 nm, and a molecular weight of about 80,000 to about 500,000.The polymer shows little adhesion of blood platelets thereto, little deformation of adhering blood platelets and an excellent antithrombogenic property. This polymer has excellent mechanical properties as an elastomer. This polymer is useful for artificial organs such as blood vessels, kidneys, hearts, and for functional biomaterials and devices such as absorbents for biological components, carriers for sustained release preparations, adhesive materials for living tissue, injectors, blood bags and catheters.

    摘要翻译: 具有重复单元的抗血栓形成合成弹性体,其包含作为包含聚醚的软链段单元的部分I和作为硬链段单元的部分II。R是直链或支链亚烷基 含有2至4个碳原子的基团,R'是酰胺氨基甲酸酯,脲,n范围高达180,m是1至20的整数,l是1至10的整数,所述聚合物具有由以下组成的微区结构: 软和硬链段,其结构域的平均尺寸为10至20nm,分子量为约80,000至约500,000。 聚合物对血小板附着力小,血小板附着变形小,抗血栓性优异。 该聚合物作为弹性体具有优异的机械性能。 该聚合物可用于人造器官如血管,肾脏,心脏,以及用于生物组分的吸收剂,持续释放制剂的载体,活组织的粘合剂材料,注射器,血袋和导管等功能生物材料和装置。

    Antithrombogenic synthetic polymer and process for its preparation
    3.
    发明授权
    Antithrombogenic synthetic polymer and process for its preparation 失效
    抗血栓形成合成聚合物及其制备方法

    公开(公告)号:US4873292A

    公开(公告)日:1989-10-10

    申请号:US154003

    申请日:1988-02-09

    IPC分类号: A61L33/06 C08G69/44

    CPC分类号: C08G69/44 A61L33/068

    摘要: An antithrombogenic synthetic polymer has repeat structural units represented by the following structural formula consisting of portions I and II: ##STR1## a microdomain structure composed of crystalline phases and amorphous phases, each phase having an average size of 5 to 10 nm, and a molecular weight in the range of about 10,000 to about 300,000. The polymer exhibits little adhesion of blood platelets thereto, an excellent antithrombogenic property and a sufficient mechanical strength.

    摘要翻译: 抗血栓形成合成聚合物具有由以下结构式表示的重复结构单元,其由I和II部分组成:由结晶相和非晶相组成的微区结构,每个相的平均尺寸为5〜10nm,分子 重量在约10,000至约300,000的范围内。 该聚合物对其血小板粘附力很小,具有优异的抗血栓形成性能和足够的机械强度。