公开(公告)号：US4687831A

公开(公告)日：1987-08-18

申请号：US852656

申请日：1986-04-16

申请人： Naoya Ogata ,  Kohei Sanui ,  Nobuhiko Yui ,  Kazuhiko Nojima ,  Kazunori Kataoka ,  Teruo Okano ,  Yasuhisa Sakurai

发明人： Naoya Ogata ,  Kohei Sanui ,  Nobuhiko Yui ,  Kazuhiko Nojima ,  Kazunori Kataoka ,  Teruo Okano ,  Yasuhisa Sakurai

IPC分类号： C08G18/00 ,  A61L27/00 ,  A61L27/18 ,  A61L33/06 ,  C08G18/10 ,  C08G18/32 ,  C08G18/65 ,  C08G18/66 ,  C08G18/76

CPC分类号： C08G18/7671 ,  A61L27/18 ,  A61L33/068 ,  C08G18/10

摘要： Antithrombogenic synthetic elastomer having repeat units comprising portion I which is a soft segment unit containing a polyether and portion II which is a hard segment unit: ##STR1## R is a straight-chain or branched-chain alkylene group containing 2 to 4 carbon atoms, R' is amide a urethane, an urea, n ranges up to 180, m is an integer of 1 to 20, l is an integer of 1 to 10, said polymer having a microdomain structure composed of soft and hard segments, the domains of which have an average size of 10 to 20 nm, and a molecular weight of about 80,000 to about 500,000.The polymer shows little adhesion of blood platelets thereto, little deformation of adhering blood platelets and an excellent antithrombogenic property. This polymer has excellent mechanical properties as an elastomer. This polymer is useful for artificial organs such as blood vessels, kidneys, hearts, and for functional biomaterials and devices such as absorbents for biological components, carriers for sustained release preparations, adhesive materials for living tissue, injectors, blood bags and catheters.

摘要翻译： 具有重复单元的抗血栓形成合成弹性体，其包含作为包含聚醚的软链段单元的部分I和作为硬链段单元的部分II。R是直链或支链亚烷基 含有2至4个碳原子的基团，R'是酰胺氨基甲酸酯，脲，n范围高达180，m是1至20的整数，l是1至10的整数，所述聚合物具有由以下组成的微区结构： 软和硬链段，其结构域的平均尺寸为10至20nm，分子量为约80,000至约500,000。 聚合物对血小板附着力小，血小板附着变形小，抗血栓性优异。 该聚合物作为弹性体具有优异的机械性能。 该聚合物可用于人造器官如血管，肾脏，心脏，以及用于生物组分的吸收剂，持续释放制剂的载体，活组织的粘合剂材料，注射器，血袋和导管等功能生物材料和装置。

公开(公告)号：US4873292A

公开(公告)日：1989-10-10

申请号：US154003

申请日：1988-02-09

申请人： Naoya Ogata ,  Kohei Sanui ,  Nobuhiko Yui ,  Kazunori Kataoka ,  Teruo Okano ,  Yasuhisa Sakurai

发明人： Naoya Ogata ,  Kohei Sanui ,  Nobuhiko Yui ,  Kazunori Kataoka ,  Teruo Okano ,  Yasuhisa Sakurai

IPC分类号： A61L33/06 ,  C08G69/44

CPC分类号： C08G69/44 ,  A61L33/068

摘要： An antithrombogenic synthetic polymer has repeat structural units represented by the following structural formula consisting of portions I and II: ##STR1## a microdomain structure composed of crystalline phases and amorphous phases, each phase having an average size of 5 to 10 nm, and a molecular weight in the range of about 10,000 to about 300,000. The polymer exhibits little adhesion of blood platelets thereto, an excellent antithrombogenic property and a sufficient mechanical strength.

摘要翻译： 抗血栓形成合成聚合物具有由以下结构式表示的重复结构单元，其由I和II部分组成：由结晶相和非晶相组成的微区结构，每个相的平均尺寸为5〜10nm，分子 重量在约10,000至约300,000的范围内。 该聚合物对其血小板粘附力很小，具有优异的抗血栓形成性能和足够的机械强度。

公开(公告)号：US5483008A

公开(公告)日：1996-01-09

申请号：US14285

申请日：1993-02-05

申请人： Yasuhisa Sakurai ,  Teruo Okano ,  Masayuki Yokoyama ,  Kazunori Kataoka ,  Yukio Nagasaki ,  Nobuyuki Ohsako ,  Masao Kato

发明人： Yasuhisa Sakurai ,  Teruo Okano ,  Masayuki Yokoyama ,  Kazunori Kataoka ,  Yukio Nagasaki ,  Nobuyuki Ohsako ,  Masao Kato

IPC分类号： C08G65/26 ,  C08G65/329 ,  C08G65/334 ,  C08G65/10 ,  C08G65/32

CPC分类号： C08G65/3348 ,  C08G65/2639 ,  C08G65/329

摘要： The present invention relates to a bifunctional polyether having groups different from each other at both ends, with a polymerization degree of 5 to 10000 and consisting of repeating units each represented by the following formula (I): ##STR1## (wherein R.sub.1, represents a hydrogen atom, halogen atom, or a lower alkyl group optionally substituted by a halogen atom, and R.sub.1 in each repeating unit may be the same or different), as well as to a process for the preparation thereof and a polymerization initiator therefor. The process of production and polymerization initiator of the present invention enable 100% introduction of a primary amino group into one of the ends of polyether.

摘要翻译： 本发明涉及两端具有不同基团的双官能聚醚，聚合度为5〜10000，由下式（I）表示的重复单元构成：其中R1 表示氢原子，卤素原子或任选被卤素原子取代的低级烷基，各重复单元中的R 1可以相同或不同），以及其制备方法及其聚合引发剂 。 本发明的制备和聚合引发剂的方法可以将100％的伯氨基引入聚醚的一个端部。

公开(公告)号：US5478575A

公开(公告)日：1995-12-26

申请号：US37383

申请日：1993-03-26

申请人： Tsuyoshi Miyazaki ,  Yoshishige Murata ,  Daijiro Shiino ,  Kazunori Waki ,  Yasuhisa Sakurai ,  Teruo Okano ,  Kazunori Kataoka ,  Yoshiyuki Koyama ,  Masayuki Yokoyama ,  Shigeru Kitano

发明人： Tsuyoshi Miyazaki ,  Yoshishige Murata ,  Daijiro Shiino ,  Kazunori Waki ,  Yasuhisa Sakurai ,  Teruo Okano ,  Kazunori Kataoka ,  Yoshiyuki Koyama ,  Masayuki Yokoyama ,  Shigeru Kitano

IPC分类号： A61K9/00 ,  A61K47/32 ,  A61K47/36 ,  A61K47/48 ,  A61K38/28

CPC分类号： A61K9/0019 ,  A61K47/32 ,  A61K47/36 ,  A61K47/48176 ,  A61K47/4823 ,  Y10S514/866

摘要： The present invention provides a polymer complex of a sugar response type having boronic acid groups in the polymer. Medicines may be contained or linked, preferably, the medicines have hydroxy groups. The polymer having boronic acid groups and the medicine having hydroxy groups may be linked by boronic acid ester bonds. The complex may also comprises polymers having boronic acid groups and polymers having hydroxy groups, and these polymers may be cross-linked.

摘要翻译： 本发明提供了在聚合物中具有硼酸基团的糖响应型聚合物复合物。 药物可以包含或连接，优选地，药物具有羟基。 具有硼酸基团的聚合物和具有羟基的药物可以通过硼酸酯键连接。 络合物还可以包含具有硼酸基团的聚合物和具有羟基的聚合物，并且这些聚合物可以是交联的。

公开(公告)号：US5412072A

公开(公告)日：1995-05-02

申请号：US496741

申请日：1990-03-21

申请人： Yasuhisa Sakurai ,  Teruo Okano ,  Kazunori Kataoka ,  Noriko Yamada ,  Shohei Inoue ,  Masayuki Yokoyama

发明人： Yasuhisa Sakurai ,  Teruo Okano ,  Kazunori Kataoka ,  Noriko Yamada ,  Shohei Inoue ,  Masayuki Yokoyama

IPC分类号： A61K31/70 ,  A61K9/00 ,  A61K31/785 ,  A61K47/42 ,  A61K47/48 ,  A61P35/00 ,  C08G69/10 ,  C08G69/40 ,  C08G69/48 ,  C07K9/00

CPC分类号： A61K47/48315

摘要： This invention is a water-soluble high molecular polymerized drug comprising a water-soluble clock copolymer having a hydrophilic segment and a hydrophobic pharmacological-functioning segment to side chain of which a drug is bonded. The hydrophilic first segments of the present invention include polyethylene glycol, polysaccharides, polyacrylamide, and so on. The hydrophobic segments being attached to a drug include polyaspartic acid, polyglutamic acid, polylysine, or derivatives thereof. Drugs to be attached to the hydrophobic segment include anti-cancer drugs, drugs for central nerve, drugs for circulatory organs, and so on.

摘要翻译： 本发明是一种水溶性高分子聚合药物，其包含水溶性时钟共聚物，该水溶性时钟共聚物具有亲水链段和与药物结合的侧链的疏水性药理功能性区段。 本发明的亲水性第一链段包括聚乙二醇，多糖，聚丙烯酰胺等。 附着于药物的疏水性片段包括聚天冬氨酸，聚谷氨酸，聚赖氨酸或其衍生物。 附着于疏水性片段的药物包括抗癌药物，中枢神经药物，循环器官药物等。

公开(公告)号：US5449513A

公开(公告)日：1995-09-12

申请号：US105535

申请日：1993-08-11

申请人： Masayuki Yokoyama ,  Yasuhisa Sakurai ,  Teruo Okano ,  Kazunori Kataoka

发明人： Masayuki Yokoyama ,  Yasuhisa Sakurai ,  Teruo Okano ,  Kazunori Kataoka

IPC分类号： A61K9/00 ,  A61K9/107 ,  A61K9/51 ,  A61K47/34 ,  A61K47/48 ,  C08G69/10 ,  A61K9/127 ,  A61K31/74

CPC分类号： C08G69/10 ,  A61K9/1075 ,  Y10T428/2985 ,  Y10T428/2989

摘要： The present invention relates to drug carriers composed of a block copolymer having hydrophilic and hydrophobic segments, a polymeric micelle type drug comprising hydrophobic drugs trapped by physical treatments in said drug carrier and methods for trapping hydrophobic drugs in the drug carrier. The drugs carrier composed of the block copolymer according to the invention forms a stable polymeric micelle structure with which hydrophobic drugs can be incorporated very efficiently via physical trapping. It was found that the incorporated drug is stably maintained in micelles even in the presence of serum. In addition, a drug difficult to administer into the living body owing to sparing water-solubility for its high hydrophobicity can be administered in the form of polymeric micelle drug.

摘要翻译： 本发明涉及由具有亲水和疏水性片段的嵌段共聚物组成的药物载体，包含通过所述药物载体中的物理治疗而被捕获的疏水性药物的聚合物胶束型药物和用于在药物载体中捕获疏水性药物的方法。 由根据本发明的嵌段共聚物组成的药物载体形成稳定的聚合胶束结构，通过物理捕获可以非常有效地引入疏水性药物。 发现即使在血清存在下，掺入的药物稳定地保持在胶束中。 此外，由于疏水性高的水溶性而难以施用于生物体的药物可以以聚合物胶束药物的形式施用。

公开(公告)号：US5284766A

公开(公告)日：1994-02-08

申请号：US817954

申请日：1992-01-07

申请人： Teruo Okano ,  Kazunori Kataoka ,  Noriko Yamada ,  Yasuhisa Sakurai ,  Takayuki Amiya ,  Akira Mamada

发明人： Teruo Okano ,  Kazunori Kataoka ,  Noriko Yamada ,  Yasuhisa Sakurai ,  Takayuki Amiya ,  Akira Mamada

IPC分类号： C12N5/00 ,  C12N5/06

CPC分类号： C12N5/0068 ,  C12N2533/30

摘要： Disclosed is a bed material whereby cultured or grown cells are collected or detached from the material without a proteolysis enzyme or chemical material. The bed material comprises a support and a coating thereon, wherein the coating is formed from a polymer or copolymer which has a critical solution temperature to water within the range of 0.degree. C. to 80.degree. C.

摘要翻译： 公开了一种床材料，其中培养的或生长的细胞在没有蛋白水解酶或化学材料的情况下从材料中收集或分离。 床料包括载体和其上的涂层，其中涂层由聚合物或共聚物形成，该聚合物或共聚物具有在0摄氏度至80摄氏度范围内的水的临界溶解温度。

公开(公告)号：US5510103A

公开(公告)日：1996-04-23

申请号：US465499

申请日：1995-06-05

申请人： Masayuki Yokoyama ,  Yasuhisa Sakurai ,  Teruo Okano ,  Kazunori Kataoka

发明人： Masayuki Yokoyama ,  Yasuhisa Sakurai ,  Teruo Okano ,  Kazunori Kataoka

IPC分类号： A61K9/00 ,  A61K9/107 ,  A61K9/51 ,  A61K47/34 ,  A61K47/48 ,  C08G69/10 ,  A61K31/74 ,  A61K9/127

CPC分类号： C08G69/10 ,  A61K9/1075 ,  Y10T428/2985 ,  Y10T428/2989

摘要： The present invention relates to drug carriers composed of a block copolymer having hydrophilic and hydrophobic segments, a polymeric micelle type drug comprising hydrophobic drugs trapped by physical treatments in said drug carrier and methods for trapping hydrophobic drugs in the drug carrier. The drugs carrier composed of the block copolymer according to the invention forms a stable polymeric micelle structure with which hydrophobic drugs can be incorporated very efficiently via physical trapping. It was found that the incorporated drug is stably maintained in micelles even in the presence of serum. In addition, a drug difficult to administer into the living body owing to sparing water-solubility for its high hydrophobicity can be administered in the form of polymeric micelle drug.

公开(公告)号：US20060025330A1

公开(公告)日：2006-02-02

申请号：US11230564

申请日：2005-09-21

申请人： Yasuhisa Sakurai ,  Teruo Okano ,  Kazunori Kataoka ,  Masayuki Yokoyama ,  Satoshi Katayose ,  Satoru Suwa ,  Atsushi Harada

发明人： Yasuhisa Sakurai ,  Teruo Okano ,  Kazunori Kataoka ,  Masayuki Yokoyama ,  Satoshi Katayose ,  Satoru Suwa ,  Atsushi Harada

IPC分类号： A61K48/00 ,  A61K38/22

CPC分类号： A61K9/1075

摘要： The present invention provides an electrostatic bonding macromolecular micelle drug carrier comprising a block copolymer having a non-chargeable segment and a chargeable segment, for stably carrying a chargeable drug tending to be easily decomposed in vivo such as protein and DNA.

公开(公告)号：US06294614B1

公开(公告)日：2001-09-25

申请号：US09230535

申请日：1999-01-27

申请人： Kazunori Kataoka ,  Masao Kato ,  Yukio Nagasaki ,  Hotaka Ito ,  Teiji Tsuruta ,  Yasuhisa Sakurai ,  Teruo Okano ,  Ken Suzuki

发明人： Kazunori Kataoka ,  Masao Kato ,  Yukio Nagasaki ,  Hotaka Ito ,  Teiji Tsuruta ,  Yasuhisa Sakurai ,  Teruo Okano ,  Ken Suzuki

IPC分类号： C08F2012

CPC分类号： C08F297/026 ,  A61L27/16 ,  A61L27/34 ,  A61L29/085 ,  A61L33/064 ,  C08F265/04 ,  C08F290/06 ,  C08F290/061 ,  C08F291/00 ,  C08F297/02 ,  C08L33/14 ,  C08L51/00

摘要： Modified polymers containing a poly(2-hydroxyethyl(meth)acrylate) chain as the hydrophilic polymer segment in which a hydrophobic polymer chain or a lipid residue of a sterol is bound to either end of the poly(2-hydroxyethyl(meth)acrylate) chain through a covalent bond or in which the poly(2-hydroxyethyl(meth)acrylate) chain is grafted onto the backbone chain at either end thereof. These modified polymers are excellent in compatibility with liquid or a living body, thus being advantageously usable particularly in medical fields.

摘要翻译： 含有聚（2-羟乙基（甲基）丙烯酸酯）链的改性聚合物作为亲水性聚合物链段，其中疏水性聚合物链或固醇的脂质残基与聚（（甲基）丙烯酸2-羟基乙酯）的任一端结合， 通过共价键或其中聚（2-羟乙基（甲基）丙烯酸酯）链在其任一端接枝到主链上。 这些改性聚合物与液体或活体的相容性优异，因此特别适用于医疗领域。