公开(公告)号：US20050177316A1

公开(公告)日：2005-08-11

申请号：US10944821

申请日：2004-09-21

申请人： Naoyuki Kamatani ,  Toshikazu Ito ,  Yutaka Kitamura

发明人： Naoyuki Kamatani ,  Toshikazu Ito ,  Yutaka Kitamura

IPC分类号： G01N33/48 ,  G01N33/50 ,  G06F19/00 ,  G06F19/18

CPC分类号： G16B20/00 ,  G16B40/00

摘要： A method of estimating, in addition to haplotype frequencies and diplotype configurations, a means and a standard deviation determining a distribution of a quantitative phenotype by the diplotype on the basis of data on observed genotypes and phenotype data taking a continuous value. The method includes a step a of calculating the maximum likelihood (L0max) on the basis of genotype data and phenotype data taking a continuous value by using as parameters haplotype frequencies and a means and a standard deviation determining a distribution of a quantitative phenotype, under the hypothesis that there is no association between a diplotype configuration including a predetermined haplotype and a predetermined phenotype, and maximum likelihood estimates and the maximum likelihood (Lmax) of haplotype frequencies and penetration rate obtained by maximizing the likelihood under the hypothesis that there is an association between the diplotype configuration including the predetermined haplotype and the phenotype distribution taking a continuous value, and a step b of obtaining the means and the standard deviation determining a distribution of a quantitative phenotype from the maximum likelihood estimates obtained in the step a.

摘要翻译： 除了单体型频率和外型配置之外，还根据观察到的基因型和表型数据的数据采用连续值来估计通过外型确定定量表型的分布的方法和标准偏差。 该方法包括基于基因型数据和使用作为参数单倍型频率的连续值的表型数据来计算最大可能性（L max max）的步骤a和确定a 在包括预定单倍型和预定表型的外形型配置与最大似然估计和单倍型频率的最大似然（L max max）之间没有关联的假设下，定量表型的分布和 通过使包含预定单倍型的外形类型配置与取连续值的表型分布之间存在关联的假设来最大化可能性所获得的穿透率，以及获得均值和标准偏差的步骤b，该步骤确定定量 从步骤a中获得的最大似然估计的表型。

公开(公告)号：US20050095629A1

公开(公告)日：2005-05-05

申请号：US10939153

申请日：2004-09-10

申请人： Toshio Furuta ,  Naoyuki Kamatani ,  Yoshihiro Nakamura ,  Toshikazu Ito ,  Eisuke Inoue

发明人： Toshio Furuta ,  Naoyuki Kamatani ,  Yoshihiro Nakamura ,  Toshikazu Ito ,  Eisuke Inoue

IPC分类号： C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G06F17/15 ,  G06F17/30 ,  G06F19/00 ,  G06F19/22

CPC分类号： G06K9/6247 ,  G16B20/00

摘要： Multi-dimensional scaling is used to solve characteristic polynomials of similarity matrixes, in order to determine a minimal-number SNP set (htSNPs (haplotype-tagging SNPS)) for identifying an arbitrary number of haplotypes in blocks with strong linkage disequilibrium. Thus, unnecessary SNP typing in blocks with strong linkage disequilibrium can be avoided.

摘要翻译： 多尺度缩放用于解决相似性矩阵的特征多项式，以便确定用于识别具有强连锁不平衡的块中任意数量的单倍型的最小数目SNP集合（htSNP（单倍型标签SNPS））。 因此，可以避免具有强连锁不平衡的块的不必要的SNP分型。

公开(公告)号：US20050050129A1

公开(公告)日：2005-03-03

申请号：US10840645

申请日：2004-05-07

申请人： Naoyuki Kamatani ,  Toshikazu Ito

发明人： Naoyuki Kamatani ,  Toshikazu Ito

IPC分类号： G01N33/48 ,  C12N15/09 ,  G06F17/15

CPC分类号： G16B20/00

摘要： A method of simultaneously estimating a diplotype-based penetrance as well as haplotype frequencies and diplotype configurations on the basis of observed genotype and phenotype data. The method includes a step a of calculating, on the basis of genotype data and phenotype data with haplotype frequencies and penetrance used as parameters, the maximum likelihood (L0max) obtained by maximizing likelihood under the hypothesis that there is no association between predetermined diplotype configurations and a predetermined phenotype, the maximum likelihood estimates of haplotype frequencies and penetrances, the maximum likelihood (Lmax) obtained by maximizing likelihood under the hypothesis that there is an association between the predetermined diplotype configurations and the predetermined phenotype; and a step b of calculating the penetrance from the maximum likelihood estimate obtained in said step a.

摘要翻译： 基于观察到的基因型和表型数据，同时估计基于外文型的外显率以及单倍型频率和外来型配置的方法。 该方法包括基于具有单倍型频率和用作参数的外显率的基因型数据和表型数据计算最大可能性（L0max），该最大似然（L0max）是通过在预定的外形类型配置之间没有关联的假设下最大化可能性而得到的 预定表型，单倍型频率和外显率的最大似然估计，在预定外型配置与预定表型之间存在关联的假设下通过使可能性最大化而获得的最大似然（Lmax）; 以及从所述步骤a中获得的最大似然估计计算外显率的步骤b。

公开(公告)号：US20050089906A1

公开(公告)日：2005-04-28

申请号：US10943299

申请日：2004-09-17

申请人： Toshio Furuta ,  Masao Yanagisawa ,  Naoyuki Kamatani

发明人： Toshio Furuta ,  Masao Yanagisawa ,  Naoyuki Kamatani

IPC分类号： C12N15/09 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G06F17/10 ,  G06F17/18 ,  G06F19/00 ,  G06F19/22

CPC分类号： G16B40/00

摘要： An EM algorithm and a graph structure are combined so that all haplotype information to be assumed is kept, thus changing a problem into one for searching for a complete graph having a maximum score for haplotype estimation.

摘要翻译： 组合EM算法和图形结构，使得保留所有假设的单体型信息，从而将问题改变为用于搜索具有用于单倍型估计的最大分数的完整图形的问题。

公开(公告)号：US20130211329A1

公开(公告)日：2013-08-15

申请号：US13814979

申请日：2010-08-13

申请人： Naoyuki Kamatani ,  Tadashi Ishikawa ,  Yoshiaki Hasebe

发明人： Naoyuki Kamatani ,  Tadashi Ishikawa ,  Yoshiaki Hasebe

IPC分类号： A61M5/50

CPC分类号： A61M5/5086 ,  A61B5/02042 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M5/16831 ,  A61M5/16836 ,  A61M2205/15

摘要： A liquid leakage detection system requiring no power supply from an outer source and configured to be relatively simple and moderate in price. A liquid leakage detection system (10) including an infusion tube (11), a syringe needle (12) coupled to the infusion tube (11), an absorbent element (16) adapted to be placed in the vicinity of a point (12a) of the syringe needle (12) to be pricked through a patient skin and a sensor unit (14) located on an upper side or within the absorbent element (16).

摘要翻译： 一种液体泄漏检测系统，不需要外部电源供电并且被配置为相对简单和价格适中。 一种液体泄漏检测系统（10），包括输注管（11），联接到输注管（11）的注射器针头（12），适于放置在点（12a）附近的吸收元件（16） 通过患者皮肤刺穿的注射器针头（12）和位于吸收体（16）的上侧或内部的传感器单元（14）。

公开(公告)号：US07601828B2

公开(公告)日：2009-10-13

申请号：US11434940

申请日：2006-05-16

申请人： Tsutomu Ogata ,  Naoyuki Kamatani ,  Tomonobu Hasegawa

发明人： Tsutomu Ogata ,  Naoyuki Kamatani ,  Tomonobu Hasegawa

IPC分类号： C12N15/12 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

摘要： Evaluation methods for evaluating susceptibility to multifactorial diseases in sexual differentiation disorders, human estrogen receptor alpha (α) genes carrying single nucleotide polymorphisms (SNPs) associated with the multifactorial diseases, DNAs containing the nucleotides at the SNPs, and diagnostic markers containing the DNAs are provided. Susceptibility to the multifactorial diseases can be evaluated by examining at least one of SNPs 8 to 14, or SNPs 10 to 14, in a human estrogen receptor α gene, and more precisely evaluated by examining a diplotype encompassing SNPs 10 to 14.

摘要翻译： 提供评估性分化障碍多因素疾病易感性的评价方法，携带与多因素疾病相关的单核苷酸多态性（SNP）的人类雌激素受体α（α）基因，含有SNP的核苷酸的DNA和含有DNA的诊断标记物 。 可以通过检查人类雌激素受体α基因中的SNP 8至14或SNP 10至14中的至少一种来评估对多因素疾病的易感性，并且通过检查包含SNP 10至14的外源类型进行更准确的评估。

公开(公告)号：US08946501B2

公开(公告)日：2015-02-03

申请号：US13814979

申请日：2010-08-13

申请人： Naoyuki Kamatani ,  Tadashi Ishikawa ,  Yoshiaki Hasebe

发明人： Naoyuki Kamatani ,  Tadashi Ishikawa ,  Yoshiaki Hasebe

IPC分类号： A61F13/15 ,  A61M5/50 ,  A61B5/02 ,  A61M5/168 ,  A61M1/36

CPC分类号： A61M5/5086 ,  A61B5/02042 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M5/16831 ,  A61M5/16836 ,  A61M2205/15

摘要： A liquid leakage detection system requiring no power supply from an outer source and configured to be relatively simple and moderate in price. A liquid leakage detection system (10) including an infusion tube (11), a syringe needle (12) coupled to the infusion tube (11), an absorbent element (16) adapted to be placed in the vicinity of a point (12a) of the syringe needle (12) to be pricked through a patient skin and a sensor unit (14) located on an upper side or within the absorbent element (16).

摘要翻译： 一种液体泄漏检测系统，不需要外部电源供电并且被配置为相对简单和价格适中。 一种液体泄漏检测系统（10），包括输注管（11），联接到输注管（11）的注射器针头（12），适于放置在点（12a）附近的吸收元件（16） 通过患者皮肤刺穿的注射器针头（12）和位于吸收体（16）的上侧或内部的传感器单元（14）。

公开(公告)号：US20090298838A1

公开(公告)日：2009-12-03

申请号：US11991808

申请日：2006-09-08

申请人： Naoyuki Kamatani ,  Atsuo Taniguchi

发明人： Naoyuki Kamatani ,  Atsuo Taniguchi

IPC分类号： A61K31/4985 ,  C12Q1/68 ,  A61P19/02

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156

摘要： Problems: Provided are a test method of determining an effective dose of methotrexate in each patient and a method for treatment of rheumatoid arthritis.Means to Solve the Problems: There is obtained a test method of an A1298C polymorphism in MTHFR gene in a patient suffering from rheumatoid arthritis, the method being used for the determination of the effective dose of methotrexate in each patient, whereby a method for treatment of rheumatoid arthritis in each patient is also obtained.

摘要翻译： 问题：提供了确定每位患者甲氨蝶呤有效剂量的测试方法和治疗类风湿性关节炎的方法。 解决问题的手段：在患有类风湿性关节炎的患者中获得MTHFR基因中的A1298C多态性的测试方法，该方法用于测定每位患者中甲氨蝶呤的有效剂量，其中治疗方法 也可以获得每个患者的类风湿关节炎。

公开(公告)号：US20070269809A1

公开(公告)日：2007-11-22

申请号：US11434940

申请日：2006-05-16

申请人： Tsutomu Ogata ,  Naoyuki Kamatani ,  Tomonobu Hasegawa

发明人： Tsutomu Ogata ,  Naoyuki Kamatani ,  Tomonobu Hasegawa

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

摘要： Evaluation methods for evaluating susceptibility to multifactorial diseases in sexual differentiation disorders, human estrogen receptor alpha (α) genes carrying single nucleotide polymorphisms (SNPs) associated with the multifactorial diseases, DNAs containing the nucleotides at the SNPs, and diagnostic markers containing the DNAs are provided.Susceptibility to the multifactorial diseases can be evaluated by examining at least one of SNPs 8 to 14, or SNPs 10 to 14, in a human estrogen receptor α gene, and more precisely evaluated by examining a diplotype encompassing SNPs 10 to 14.

摘要翻译： 提供评估性分化障碍多因素疾病易感性的评价方法，携带与多因素疾病相关的单核苷酸多态性（SNP）的人类雌激素受体α（α）基因，含有SNP的核苷酸的DNA和含有DNA的诊断标记物 。 可以通过检查人类雌激素受体α基因中的SNP 8至14或SNP 10至14中的至少一种来评估对多因素疾病的易感性，并且通过检查包含SNP 10至14的外源类型进行更准确的评估。

公开(公告)号：US20050069891A1

公开(公告)日：2005-03-31

申请号：US10501647

申请日：2003-01-15

申请人： Toshiaki Susuki ,  Naoyuki Kamatani ,  Junji Tanaka

发明人： Toshiaki Susuki ,  Naoyuki Kamatani ,  Junji Tanaka

IPC分类号： C12N15/09 ,  C12Q1/68

CPC分类号： G16B20/00

摘要： The present invention is intended to provide a technique relating to a method of specifying an SNP which comprises repeating presumption of an SNP serving as a marker and detailed typing of SNPs around the same, thus gradually narrowing down the focus to the base sequence domain in which the ‘target’ SNP is likely contained and finally specifying the ‘target’ SNP at a high efficiency. As FIG. 1 shows, the method of specifying an SNP comprises: (1) determining a drug to be developed which is the subject of the determination; (2) collecting samples to be analyzed; (3) determining a ‘scanning domain (base sequence domain)’; (4) determining ‘typing’ SNPs; (5) SNP typing by the wet process and analyzing haplotypes based on the typing data; (6) presuming a ‘marker’ SNP (determining the analytical data); and (7) specifying the ‘target’ SNP (target SNP). A cycle consisting of the stage (1) to (7) is repeated as a treatment cycle.

摘要翻译： 本发明旨在提供一种涉及一种指定SNP的方法的技术，其包括重复将SNP作为标记的推测，并且在其周围的SNP的详细分型，从而逐渐将焦点缩小到碱基序列区，其中 “目标”SNP可能包含在内，最终以高效率指定“目标”SNP。 如图。 如图1所示，指定SNP的方法包括：（1）确定作为确定对象的待开发药物; （2）收集待分析样品; （3）确定“扫描域（碱基序列域）”; （4）确定“打字”SNP; （5）通过湿法进行SNP分型，并根据分型数据分析单体型; （6）假设“标记”SNP（确定分析数据）; 和（7）指定“目标”SNP（目标SNP）。 重复由阶段（1）至（7）组成的周期作为治疗周期。