公开(公告)号：US20200046714A1

公开(公告)日：2020-02-13

申请号：US16656574

申请日：2019-10-18

申请人： National Institute of Biological Sciences, Beijing

发明人： Xiaodong Wang ,  Dianrong Li ,  Lingjun Meng ,  Zhiyuan Zhang

IPC分类号： A61K31/522 ,  A61K31/165 ,  A61K31/4453 ,  A61K31/44 ,  A61K31/381 ,  A61K31/341 ,  A61K31/426 ,  A61K31/415 ,  A61K31/47 ,  A61K31/18 ,  A61K31/17 ,  A61K31/396 ,  A61K31/397 ,  A61K31/40 ,  A61K31/5375 ,  A61P15/08

摘要： The invention provides methods of treating male reproductive senescence comprising administering to a male in need thereof a necroptosis inhibitor, including inhibitors of RIP1, RIP3 or MLKL. The invention also provides pharmaceutical compositions comprising a necroptosis inhibitor and a second different drug for treating male senescence.

公开(公告)号：US11090307B2

公开(公告)日：2021-08-17

申请号：US16656574

申请日：2019-10-18

申请人： National Institute of Biological Sciences, Beijing

发明人： Xiaodong Wang ,  Dianrong Li ,  Lingjun Meng ,  Zhiyuan Zhang

IPC分类号： A61K31/52 ,  A61K31/522 ,  A61P15/08 ,  A61K31/165 ,  A61K31/17 ,  A61K31/18 ,  A61K31/341 ,  A61K31/381 ,  A61K31/396 ,  A61K31/397 ,  A61K31/40 ,  A61K31/415 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4453 ,  A61K31/47 ,  A61K31/5375

摘要： The invention provides methods of treating male reproductive senescence comprising administering to a male in need thereof a necroptosis inhibitor, including inhibitors of RIP1, RIP3 or MLKL. The invention also provides pharmaceutical compositions comprising a necroptosis inhibitor and a second different drug for treating male senescence.