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    Methods for detecting and treating cholangiocarcinoma
    2.
    发明授权
    Methods for detecting and treating cholangiocarcinoma 有权

    公开(公告)号：US11506664B1

    公开(公告)日：2022-11-22

    申请号：US17238431

    申请日：2021-04-23

    Applicant: Academia Sinica ,  National Tsing Hua University

    Inventor： Shang-Cheng Hung ,  Gwo-Bin Lee ,  Priya Gopinathan

    IPC: G01N33/574 ,  C08B37/00 ,  A61K33/243 ,  A61K31/53 ,  A61K31/7072 ,  A61K31/505 ,  A61K31/7068

    Abstract: Disclosed herein is a novel compound of formula (I) for detecting circulating cancerous cells, particularly, cholangio-cancerous cells, from a biological sample, wherein, R1 and R2 are independently H, or —SO3M; and M is a monovalent cation selected from the group consisting of sodium ion, potassium ion, lithium ion or ammonium ion. Also disclosed herein is a method of treating and detecting cholangio-cancerous cells from a biological sample of a subject suspected of having cholangiocarcinoma (CCA). The method includes steps of, contacting the biological sample with a magnetic bead pre-coated with the compound of formula (I); detecting a complex formed between the magnetic bead and the biological sample in an immunoassay; and administering to the subject an effective amount of a chemotherapeutic agent to ameliorate symptoms associated with the CCA.

    Compounds and methods for treating osteoarthritis
    4.
    发明授权
    Compounds and methods for treating osteoarthritis 有权

    公开(公告)号：US11332490B1

    公开(公告)日：2022-05-17

    申请号：US17182156

    申请日：2021-02-22

    Applicant: Academia Sinica

    Inventor： Shang-Cheng Hung ,  Chi-Huey Wong ,  Ting-Jen Cheng

    IPC: C07H7/02

    Abstract: Disclosed herein are substrates and/or inhibitors of endo-O-sulfatase 1 (Sulf-1). According to some embodiments, the substrates and/or inhibitors of Sulf-1 are compounds of formula (I) or (II), In formula (I) or (II), n is 2 or 3; X is methylene, O, or N; R1 is —SO3M, or —SO2NH2; R2 is C1-6 alkyl or C1-6 alkylamine; and M is a monovalent cation selected from the group consisting of lithium, sodium, potassium, and ammonium. Also encompasses herein are methods of identifying and treating a subject having or suspected of having osteoarthritis. The method includes steps of (a) mixing a urine sample of the subject with 4-methylumbelliferyl sulfate (4-MUS) and a Sulf-1 inhibitor of formula (I) or (II); (b) determining a fluorescence intensity of the mixture of the step (a); and (c) treating the subject with an analgesic, a non-steroidal anti-inflammatory drug (NSAID), or a corticosteroid when the determined fluorescence intensity of the step (b) is smaller than that of a control sample, which is a mixture of the urine sample and 4-MUS.

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