公开(公告)号：US09907852B2

公开(公告)日：2018-03-06

申请号：US15302863

申请日：2015-04-10

申请人： National University Corporation University of Toyama ,  Kracie Pharma, Ltd. ,  National Cancer Center ,  Tokyo University of Science Foundation

发明人： Hiroyasu Esumi ,  Masafumi Ikeda ,  Katsuya Tsuchihara ,  Shigeki Chiba ,  Satoshi Yomoda ,  Takanori Kawashima ,  Toshiki Okubo ,  Yasuhiro Tezuka ,  Kenta Murata

IPC分类号： A61K31/34 ,  A61K36/00 ,  A61K47/22 ,  A61K36/28 ,  A61K31/7068 ,  A61K45/06 ,  A61K47/46 ,  A61K39/395 ,  C07K16/22 ,  A61K39/00

CPC分类号： A61K47/22 ,  A61K31/122 ,  A61K31/137 ,  A61K31/16 ,  A61K31/216 ,  A61K31/225 ,  A61K31/277 ,  A61K31/336 ,  A61K31/352 ,  A61K31/365 ,  A61K31/366 ,  A61K31/416 ,  A61K31/427 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/551 ,  A61K31/5685 ,  A61K31/60 ,  A61K31/7068 ,  A61K31/7072 ,  A61K36/28 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/46 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/76 ,  A61K2300/00

摘要： The purpose of the present invention is to provide an anticancer agent for potentiating an antitumor effect, alleviating side effects, and further extending the survival rate by concomitant use with a component having an anticancer effect. An anticancer agent combining arctigenin and a component other than arctigenin that has an anticancer effect, in which the anticancer agent may be a combination drug or may be a kit configured from a formulation containing arctigenin and a formulation containing a component that has an anticancer effect, and the concomitant use of arctigenin and the component having an anticancer effect more strongly inhibits tumor growth and reduces the proportion of cancer stem cells in the tumor, making it possible to extend the total survival time and to alleviate side effects caused by the component having an anticancer effect.