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    Burdock Fruit Extract Containing Arctigenin and Method for Producing Same
    3.
    发明申请
    Burdock Fruit Extract Containing Arctigenin and Method for Producing Same 有权
    含牛蒡子苷的牛蒡果提取物及其生产方法

    公开(公告)号：US20140037770A1

    公开(公告)日：2014-02-06

    申请号：US13849302

    申请日：2013-03-22

    申请人： Kracie Pharma, Ltd. ,  National Cancer Center ,  National University Corporation University of Toyama

    发明人： Toshiki Okubo ,  Satoshi Yomoda ,  Takafumi Fuse ,  Takanori Kawashima ,  Hiroyasu Esumi ,  Chika Miyoshi ,  Shigetoshi Kadota

    IPC分类号： A61K36/28

    CPC分类号： A61K36/28 ,  A61K31/365 ,  A61K31/7048 ,  A61K2236/19 ,  C07D307/33

    摘要： The present invention is intended to provide a burdock fruit extract comprising arctigenin and arctiin at a definite ratio and a method for producing the same. More particularly, the present invention is intended to provide a method for producing a burdock fruit extract comprising arctigenin and arctiin at a weight ratio of approximately 1:1.A method for producing a burdock fruit extract comprising arctigenin and arctiin at a weight ratio of arctigenin/arctiin =0.7 to 1.3 is provided, including the steps of: cutting a burdock fruit and converting arctiin which is inherent in the burdock fruit into arctigenin by enzymatic conversion by beta-glucosidase which is inherent in the burdock fruit, wherein the enzymatic conversion includes reaction at a temperature from 20° C. to 50° C. Also provided is the method further including a step of extracting an extract comprising arctigenin and arctiin by adding an organic solvent and heating to reflux.

    摘要翻译： 本发明的目的在于提供一种以确定的比例含有抗坏血酸和铁蛋白的牛蒡果实提取物及其制造方法。 更具体地，本发明旨在提供一种生产牛蒡果实提取物的方法，所述牛蒡果实提取物包含重量比为约1:1的抗坏血酸和铁蛋白。 本发明提供一种以牛蒡子苷/ ar in in = = = = = = = a a a a i i i extract extract extract extract extract for for for for for for A A A A A A A A A A A A A A A A A A A A A enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic 牛蒡果实固有的β-葡糖苷酶的转化，其中酶促转化包括在20℃至50℃的温度下的反应。还提供了该方法还包括通过以下步骤提取包含arctigenin和arctiin的提取物： 加入有机溶剂并加热回流。

    Burdock fruit extract containing arctigenin and method for producing same
    4.
    发明授权
    Burdock fruit extract containing arctigenin and method for producing same 有权
    含有赤霉素的牛蒡果实提取物及其制造方法

    公开(公告)号：US09072718B2

    公开(公告)日：2015-07-07

    申请号：US13849302

    申请日：2013-03-22

    申请人： Kracie Pharma, Ltd. ,  National Cancer Center ,  National University Corporation University of Toyama

    发明人： Toshiki Okubo ,  Satoshi Yomoda ,  Takafumi Fuse ,  Takanori Kawashima ,  Hiroyasu Esumi ,  Chika Miyoshi ,  Shigetoshi Kadota

    IPC分类号： A01N65/00 ,  A61K36/28 ,  A61K31/365 ,  A61K31/7048 ,  C07D307/33

    CPC分类号： A61K36/28 ,  A61K31/365 ,  A61K31/7048 ,  A61K2236/19 ,  C07D307/33

    摘要： PROBLEM TO BE SOLVEDThe present invention is intended to provide a burdock fruit extract comprising arctigenin and arctiin at a definite ratio and a method for producing the same. More particularly, the present invention is intended to provide a method for producing a burdock fruit extract comprising arctigenin and arctiin at a weight ratio of approximately 1:1.SOLUTIONA method for producing a burdock fruit extract comprising arctigenin and arctiin at a weight ratio of arctigenin/arctiin=0.7 to 1.3 is provided, including the steps of: cutting a burdock fruit and converting arctiin which is inherent in the burdock fruit into arctigenin by enzymatic conversion by beta-glucosidase which is inherent in the burdock fruit, wherein the enzymatic conversion includes reaction at a temperature from 20° C. to 50° C. Also provided is the method further including a step of extracting an extract comprising arctigenin and arctiin by adding an organic solvent and heating to reflux.

    摘要翻译： 待解决的问题本发明旨在提供一种以确定的比例含有弓形虫属和弓形虫的牛蒡果实提取物及其制造方法。 更具体地，本发明旨在提供一种生产牛蒡果实提取物的方法，所述牛蒡果实提取物包含重量比为约1:1的抗坏血酸和铁蛋白。 解决方案提供一种生产牛蒡果实提取物的方法，该方法包括以赤霉素/ arctinin = 0.7〜1.3的重量比计含有赤霉素和arctiin的方法，包括以下步骤：将牛蒡水果切割成牛蒡果实固有的arctiin， 牛蒡果实中固有的β-葡糖苷酶进行酶转化，其中酶促转化包括在20℃至50℃的温度下进行反应。还提供了一种方法，其还包括提取包含抗坏血酸和脯氨酸的提取物的步骤 通过加入有机溶剂并加热回流。