公开(公告)号：US20170028065A1

公开(公告)日：2017-02-02

申请号：US15302863

申请日：2015-04-10

申请人： National University Corporation University of Toyama ,  Kracie Pharma, Ltd. ,  National Cancer Center ,  Tokyo University of Science Foundation

发明人： Hiroyasu Esumi ,  Kouji IKEDA ,  Katsuya TSUCHIHARA ,  Shigeki Chiba ,  Satoshi Yomoda ,  Takanori Kawashima ,  Toshiki Okubo ,  Yasuhiro TEZUKA ,  Kenta MURATA

IPC分类号： A61K47/22 ,  A61K45/06 ,  A61K39/395 ,  A61K47/46 ,  A61K31/7068

CPC分类号： A61K47/22 ,  A61K31/122 ,  A61K31/137 ,  A61K31/16 ,  A61K31/216 ,  A61K31/225 ,  A61K31/277 ,  A61K31/336 ,  A61K31/352 ,  A61K31/365 ,  A61K31/366 ,  A61K31/416 ,  A61K31/427 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/551 ,  A61K31/5685 ,  A61K31/60 ,  A61K31/7068 ,  A61K31/7072 ,  A61K36/28 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/46 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/76 ,  A61K2300/00

摘要： The purpose of the present invention is to provide an anticancer agent for potentiating an antitumor effect, alleviating side effects, and further extending the survival rate by concomitant use with a component having an anticancer effect. An anticancer agent combining arctigenin and a component other than arctigenin that has an anticancer effect, in which the anticancer agent may be a combination drug or may be a kit configured from a formulation containing arctigenin and a formulation containing a component that has an anticancer effect, and the concomitant use of arctigenin and the component having an anticancer effect more strongly inhibits tumor growth and reduces the proportion of cancer stem cells in the tumor, making it possible to extend the total survival time and to alleviate side effects caused by the component having an anticancer effect.

摘要翻译： 本发明的目的是提供一种用于增强抗肿瘤效果，减轻副作用的抗癌剂，并且通过伴随使用具有抗癌作用的成分来进一步延长存活率。 将抗坏血酸蛋白和除抗坏血酸素以外的成分相结合的抗癌剂，其具有抗癌作用，其中抗癌剂可以是组合药物，也可以是由含有抗坏血青霉素的制剂和含有抗癌作用的成分的制剂构成的试剂盒， 并且伴随使用抗坏血酸素和具有抗癌作用的成分更强烈地抑制肿瘤生长并降低肿瘤中癌干细胞的比例，从而可以延长总存活时间并减轻由具有抗癌作用的成分引起的副作用 抗癌作用。

公开(公告)号：US09907852B2

公开(公告)日：2018-03-06

申请号：US15302863

申请日：2015-04-10

申请人： National University Corporation University of Toyama ,  Kracie Pharma, Ltd. ,  National Cancer Center ,  Tokyo University of Science Foundation

发明人： Hiroyasu Esumi ,  Masafumi Ikeda ,  Katsuya Tsuchihara ,  Shigeki Chiba ,  Satoshi Yomoda ,  Takanori Kawashima ,  Toshiki Okubo ,  Yasuhiro Tezuka ,  Kenta Murata

IPC分类号： A61K31/34 ,  A61K36/00 ,  A61K47/22 ,  A61K36/28 ,  A61K31/7068 ,  A61K45/06 ,  A61K47/46 ,  A61K39/395 ,  C07K16/22 ,  A61K39/00

CPC分类号： A61K47/22 ,  A61K31/122 ,  A61K31/137 ,  A61K31/16 ,  A61K31/216 ,  A61K31/225 ,  A61K31/277 ,  A61K31/336 ,  A61K31/352 ,  A61K31/365 ,  A61K31/366 ,  A61K31/416 ,  A61K31/427 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/551 ,  A61K31/5685 ,  A61K31/60 ,  A61K31/7068 ,  A61K31/7072 ,  A61K36/28 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/46 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/76 ,  A61K2300/00

摘要： The purpose of the present invention is to provide an anticancer agent for potentiating an antitumor effect, alleviating side effects, and further extending the survival rate by concomitant use with a component having an anticancer effect. An anticancer agent combining arctigenin and a component other than arctigenin that has an anticancer effect, in which the anticancer agent may be a combination drug or may be a kit configured from a formulation containing arctigenin and a formulation containing a component that has an anticancer effect, and the concomitant use of arctigenin and the component having an anticancer effect more strongly inhibits tumor growth and reduces the proportion of cancer stem cells in the tumor, making it possible to extend the total survival time and to alleviate side effects caused by the component having an anticancer effect.

公开(公告)号：US09700572B2

公开(公告)日：2017-07-11

申请号：US14494637

申请日：2014-09-24

申请人： Kracie Pharma, Ltd. ,  NATIONAL CANCER CENTER ,  National University Corporation University of Toyama

发明人： Hiroyasu Esumi ,  Masafumi Ikeda ,  Chika Miyoshi ,  Shigetoshi Kadota ,  Toshiki Okubo ,  Satoshi Yomoda ,  Takafumi Fuse ,  Takanori Kawashima ,  Shigeki Chiba

IPC分类号： A61K31/7048 ,  A61K31/7034 ,  A61K31/341 ,  A61K31/365 ,  A61K36/28

CPC分类号： A61K31/7048 ,  A61K31/341 ,  A61K31/365 ,  A61K31/7034 ,  A61K36/28 ,  A61K2300/00

摘要： The present invention is intended to provide a novel anticancer agent which is effective to a cancer. After administering an agent prepared using burdock fruit extract to a pancreas cancer patient so that a dose of arctigenin was 100 mg or more per day, the tumor reducing effect was observed, and, in addition, lowering of tumor markers was confirmed. The present invention provides an anticancer agent containing arctigenin, wherein a dose of the arctigenin is 100 mg or more per day. In addition, the present invention provides the anticancer agent containing arctigenin and arctiin at a weight ratio of arctigenin/arctiin=0.7 to 1.3.