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    Coated implantable medical device
    4.
    发明授权
    Coated implantable medical device 失效
    涂层可植入医疗器械

    公开(公告)号：US5609629A

    公开(公告)日：1997-03-11

    申请号：US484532

    申请日：1995-06-07

    申请人： Neal E. Fearnot ,  Thomas G. Kozma ,  Anthony O. Ragheb ,  William D. Voorhees

    发明人： Neal E. Fearnot ,  Thomas G. Kozma ,  Anthony O. Ragheb ,  William D. Voorhees

    IPC分类号： A61B17/00 ,  A61F2/00 ,  A61K9/00 ,  A61K51/12 ,  A61L27/30 ,  A61L27/54 ,  A61L29/08 ,  A61L29/10 ,  A61L29/16 ,  A61L31/00 ,  A61L31/08 ,  A61L31/10 ,  A61L31/16 ,  A61L33/02 ,  A61M37/00 ,  A61N5/10 ,  A61F2/06

    CPC分类号： A61L31/088 ,  A61K51/1282 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61F2250/0068 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/608 ,  A61N5/1002

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material positioned over the structure 12; and at least one porous layer 20 positioned over the bioactive material layer 18. Preferably, the structure 12 is a coronary stent, and the bioactive material is at least one of heparin, dexamethasone or a dexamethasone derivative. The device 10 includes layers 18 and 22 of heparin and dexamethasone, the layer 22 of dexamethasone being positioned above the layer 18 of heparin. The layers of bioactive material also can be individual materials or a combination of different materials. Unexpectedly, the more soluble heparin markedly promotes the release of the less soluble dexamethasone above it. The porous layer 20 is composed of a polymer applied by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyimide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 位于结构12上方的生物活性材料的至少一层18; 以及位于生物活性材料层18上方的至少一个多孔层20.优选地，结构12是冠状动脉支架，生物活性材料是肝素，地塞米松或地塞米松衍生物中的至少一种。 装置10包括肝素和地塞米松的层18和22，地塞米松的层22位于肝素层18之上。 生物活性材料的层也可以是单独的材料或不同材料的组合。 意外的是，较易溶解的肝素显着促进了较低溶解度的地塞米松释放。 多孔层20由通过蒸汽或等离子体沉积施加的聚合物组成，并提供生物活性材料的受控释放。 特别优选的是，聚合物是聚酰亚胺，聚对二甲苯或聚对二甲苯衍生物，它们仅通过单体蒸气的冷凝而无溶剂，热或催化剂沉积。

    COATED IMPLANTABLE MEDICAL DEVICE
    5.
    发明申请
    COATED IMPLANTABLE MEDICAL DEVICE 失效
    涂层可植入医疗器械

    公开(公告)号：US20110046723A1

    公开(公告)日：2011-02-24

    申请号：US12902788

    申请日：2010-10-12

    申请人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees, III

    发明人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees, III

    IPC分类号： A61F2/82

    CPC分类号： A61L33/022 ,  A61F2/0077 ,  A61F2/02 ,  A61F2/06 ,  A61F2/24 ,  A61F2/82 ,  A61F2/91 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61K51/1282 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  A61N5/1002 ,  C08L65/04

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。 此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。 优选地，结构12是冠状动脉支架。 多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。 特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

    Coated implantable medical device method
    6.
    发明授权
    Coated implantable medical device method 有权
    涂层可植入医疗器械方法

    公开(公告)号：US07867275B2

    公开(公告)日：2011-01-11

    申请号：US11515395

    申请日：2006-09-01

    申请人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  William D. Voorhees, III ,  Thomas G. Kozma

    发明人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  William D. Voorhees, III ,  Thomas G. Kozma

    IPC分类号： A61F2/06

    CPC分类号： A61F2/91 ,  A61F2/24 ,  A61F2/82 ,  A61F2/885 ,  A61F2250/0068 ,  A61K51/1282 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61N5/1002 ,  C08L65/04

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。 此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。 优选地，结构12是冠状动脉支架。 多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。 特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

    Coated implantable medical device
    7.
    发明授权
    Coated implantable medical device 有权
    涂层可植入医疗器械

    公开(公告)号：US07862605B2

    公开(公告)日：2011-01-04

    申请号：US11604539

    申请日：2006-11-27

    申请人： Anthony O. Ragheb ,  Brian L. Bates ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees, III

    发明人： Anthony O. Ragheb ,  Brian L. Bates ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees, III

    IPC分类号： A61F2/06

    CPC分类号： A61K51/1282 ,  A61F2/24 ,  A61F2/82 ,  A61F2250/0068 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  A61N5/1002 ,  C08L65/04

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of a bioactive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of bioactive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of bioactive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a stent graft. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative which is deposited without solvents, heat or catalysts, but rather by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12，以及至少一个位于结构的至少一个表面上的生物活性剂层18 任选地，装置10可以包括位于生物活性剂层18上方的至少一个多孔的，优选的聚合物层20，并且还可以包括至少一个被涂覆在结构12的一个表面上的涂层16， 至少一层生物活性剂层依次放置在涂层16的至少一部分上。多孔层20和涂层16各自提供生物活性材料从装置10的受控释放。结构12是 优选构造为支架移植物。 多孔层20的聚合物优选通过蒸气或等离子体沉积来施加。 特别优选的是聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不用溶剂，加热或催化剂沉积，而是通过单体蒸气的冷凝而沉积。

    COATED IMPLANTABLE MEDICAL DEVICE
    9.
    发明申请
    COATED IMPLANTABLE MEDICAL DEVICE 有权
    涂层可植入医疗器械

    公开(公告)号：US20080145399A1

    公开(公告)日：2008-06-19

    申请号：US11932113

    申请日：2007-10-31

    申请人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees

    发明人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees

    IPC分类号： A61F2/02 ,  A61P37/06

    CPC分类号： A61K51/1282 ,  A61F2/24 ,  A61F2/82 ,  A61F2250/0068 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  A61N5/1002 ,  C08L65/04

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of an immunosuppressive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of immunosuppressive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of immunosuppressive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a coronary stent. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative which is deposited without solvents, heat or catalysts, but rather by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食管，气管，结肠，胆管或尿道中的结构12，以及至少一个位于结构的至少一个表面上的免疫抑制剂层18 12。 任选地，装置10可以包括位于免疫抑制剂的层18上的至少一个多孔的，优选的聚合物层20，并且可以可选地或另外包括位于结构12的一个表面上的至少一个涂层16，至少一个 免疫抑制剂的层18再次依次涂覆在涂层16的至少一部分上。 多孔层20和涂层16各自提供生物活性材料从装置10的受控释放。 结构12优选构造为冠状动脉支架。 多孔层20的聚合物优选通过蒸气或等离子体沉积来施加。 特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不用溶剂，热或催化剂沉积，而是通过单体蒸气的冷凝而沉积。

    COATED IMPLANTABLE MEDICAL DEVICE
    10.
    发明申请
    COATED IMPLANTABLE MEDICAL DEVICE 有权
    涂层可植入医疗器械

    公开(公告)号：US20080145398A1

    公开(公告)日：2008-06-19

    申请号：US11932078

    申请日：2007-10-31

    申请人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees

    发明人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees

    IPC分类号： A61F2/02 ,  A61P37/06

    CPC分类号： A61K51/1282 ,  A61F2/24 ,  A61F2/82 ,  A61F2250/0068 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  A61N5/1002 ,  C08L65/04

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of an immunosuppressive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of immunosuppressive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of immunosuppessive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a coronary stent. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative which is deposited without solvents, heat or catalysts, but rather by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食管，气管，结肠，胆管或尿道中的结构12，以及至少一个位于结构的至少一个表面上的免疫抑制剂层18 12。 任选地，装置10可以包括位于免疫抑制剂的层18上的至少一个多孔的，优选的聚合物层20，并且可以可选地或另外包括位于结构12的一个表面上的至少一个涂层16，至少一个 免疫抑制剂层18又依次放置在涂层16的至少一部分上。 多孔层20和涂层16各自提供生物活性材料从装置10的受控释放。 结构12优选构造为冠状动脉支架。 多孔层20的聚合物优选通过蒸气或等离子体沉积来施加。 特别优选的是聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不用溶剂，加热或催化剂沉积，而是通过单体蒸气的冷凝而沉积。