公开(公告)号：US20230287106A1

公开(公告)日：2023-09-14

申请号：US18053842

申请日：2022-11-09

申请人： Neurimmune Holding AG ,  University of Zurich

发明人： Jan GRIMM ,  Fabrice HEITZ ,  Fabian WIRTH ,  Tobias WELT

IPC分类号： C07K16/26 ,  A01K67/027 ,  C07K16/18 ,  A61K47/68 ,  A61P3/10 ,  A61K39/395 ,  A61K45/06 ,  A61K49/00

CPC分类号： C07K16/26 ,  A01K67/0275 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6847 ,  A61K49/0008 ,  A61P3/10 ,  C07K16/18 ,  A61K2039/505

摘要： Described are molecules specifically binding to human islet amyloid polypeptide (hIAPP) also known as amylin, particularly human-derived antibodies as well as fragments, derivatives and variants thereof for antagonizing islet amyloid polypeptide (IAPP) induced β-cell damage and impaired glucose tolerance which are symptoms typically associated with diabetes mellitus type 2 (T2D).

公开(公告)号：US20200231667A1

公开(公告)日：2020-07-23

申请号：US16705031

申请日：2019-12-05

申请人： Neurimmune Holding AG ,  University of Zurich

发明人： Jan GRIMM ,  Fabrice HEITZ ,  Fabian WIRTH ,  Tobias WELT

IPC分类号： C07K16/26 ,  A01K67/027 ,  C07K16/18 ,  A61K47/68 ,  A61P3/10 ,  A61K39/395 ,  A61K45/06 ,  A61K49/00

摘要： Described are molecules specifically binding to human islet amyloid polypeptide (hIAPP) also known as amylin, particularly human-derived antibodies as well as fragments, derivatives and variants thereof for antagonizing islet amyloid polypeptide (IAPP) induced β-cell damage and impaired glucose tolerance winch are symptoms typically associated with diabetes mellitus type 2 (T2D).

公开(公告)号：US20180179276A1

公开(公告)日：2018-06-28

申请号：US15125450

申请日：2015-03-12

申请人： Neurimmune Holding AG ,  University of Zurich

发明人： Jan GRIMM ,  Fabrice HEITZ ,  Fabian WIRTH ,  Tobias WELT

IPC分类号： C07K16/26 ,  A61K47/68 ,  A61K49/00 ,  A61P3/10 ,  A61K45/06 ,  A61K39/395 ,  A01K67/027

CPC分类号： C07K16/26 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0312 ,  A01K2267/0362 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6847 ,  A61K49/0008 ,  A61K2039/505 ,  A61P3/10 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

摘要： Described are molecules specifically binding to human islet amyloid polypeptide (hIAPP) also known as amylin, particularly human-derived antibodies as well as fragments, derivatives and variants thereof for antagonizing islet amyloid polypeptide (IAPP) induced β-cell damage and impaired glucose tolerance which are symptoms typically associated with diabetes mellitus type 2 (T2D).

公开(公告)号：US20210107972A1

公开(公告)日：2021-04-15

申请号：US17113600

申请日：2020-12-07

申请人： Neurimmune Holding AG

发明人： Jan GRIMM ,  Fabrice HEITZ ,  Feng CHEN ,  Ioana COMBALUZIER

IPC分类号： C07K16/18 ,  C07K7/06 ,  G01N33/543 ,  G01N33/577 ,  G01N33/68 ,  C07K14/47

摘要： Provided are novel human islet amyloid polypeptide, also known as amylin and IAPP and proIAPP respectively, specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for IAPP and/or proIAPP are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for IAPP and/or proIAPP targeted immunotherapy and diagnostics, respectively.