公开(公告)号：US20230287106A1

公开(公告)日：2023-09-14

申请号：US18053842

申请日：2022-11-09

申请人： Neurimmune Holding AG ,  University of Zurich

发明人： Jan GRIMM ,  Fabrice HEITZ ,  Fabian WIRTH ,  Tobias WELT

IPC分类号： C07K16/26 ,  A01K67/027 ,  C07K16/18 ,  A61K47/68 ,  A61P3/10 ,  A61K39/395 ,  A61K45/06 ,  A61K49/00

CPC分类号： C07K16/26 ,  A01K67/0275 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6847 ,  A61K49/0008 ,  A61P3/10 ,  C07K16/18 ,  A61K2039/505

摘要： Described are molecules specifically binding to human islet amyloid polypeptide (hIAPP) also known as amylin, particularly human-derived antibodies as well as fragments, derivatives and variants thereof for antagonizing islet amyloid polypeptide (IAPP) induced β-cell damage and impaired glucose tolerance which are symptoms typically associated with diabetes mellitus type 2 (T2D).

公开(公告)号：US20200231667A1

公开(公告)日：2020-07-23

申请号：US16705031

申请日：2019-12-05

申请人： Neurimmune Holding AG ,  University of Zurich

发明人： Jan GRIMM ,  Fabrice HEITZ ,  Fabian WIRTH ,  Tobias WELT

IPC分类号： C07K16/26 ,  A01K67/027 ,  C07K16/18 ,  A61K47/68 ,  A61P3/10 ,  A61K39/395 ,  A61K45/06 ,  A61K49/00

摘要： Described are molecules specifically binding to human islet amyloid polypeptide (hIAPP) also known as amylin, particularly human-derived antibodies as well as fragments, derivatives and variants thereof for antagonizing islet amyloid polypeptide (IAPP) induced β-cell damage and impaired glucose tolerance winch are symptoms typically associated with diabetes mellitus type 2 (T2D).

公开(公告)号：US20200071390A1

公开(公告)日：2020-03-05

申请号：US16568186

申请日：2019-09-11

申请人： Neurimmune Holding AG ,  University of Zurich

发明人： Jan GRIMM ,  Roland Martin ,  Benoit Combaluzier ,  Ivan Jelcic

IPC分类号： C07K16/08 ,  C12N7/00 ,  C07K14/005 ,  A61K45/06 ,  A61K39/42 ,  G01N33/569 ,  G01N33/68

摘要： Provided are novel human-derived antibodies specifically recognizing polyomavirus polypeptides, preferably capable of binding to polyomaviruses of the type of JC virus (JCV) and/or BK virus (BKV) as well as methods related thereto. Furthermore, assays and kits related to antibodies specific for polyomaviruses, polyomavirus VP1 and or polyomavirus VP1 Virus-Like Particles (VLPs), preferably of the type of JCV and/or BKV, are disclosed. The human-derived antibodies as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for polyomavirus targeted immunotherapy and diagnostics.

公开(公告)号：US20180037635A1

公开(公告)日：2018-02-08

申请号：US15678965

申请日：2017-08-16

申请人： Neurimmune Holding AG ,  University of Zurich

发明人： Jan GRIMM ,  Roland MARTIN ,  Benoit COMBALUZIER ,  Ivan JELCIC

IPC分类号： C07K16/08 ,  C07K14/005 ,  G01N33/569 ,  C12N7/00 ,  A61K39/42 ,  A61K45/06 ,  G01N33/68

CPC分类号： C07K16/084 ,  A61K39/42 ,  A61K45/06 ,  C07K14/005 ,  C07K16/081 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C12N7/00 ,  C12N2710/22022 ,  G01N33/56983 ,  G01N33/6893 ,  G01N2333/025

摘要： Provided are novel human-derived antibodies specifically recognizing polyomavirus polypeptides, preferably capable of binding to polyomaviruses of the type of JC virus (JCV) and/or BK virus (BKV) as well as methods related thereto. Furthermore, assays and kits related to antibodies specific for polyomaviruses, polyomavirus VP1 and or polyomavirus VP1 Virus-Like Particles (VLPs), preferably of the type of JCV and/or BKV, are disclosed. The human-derived antibodies as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for polyomavirus targeted immunotherapy and diagnostics.

公开(公告)号：US20170369592A1

公开(公告)日：2017-12-28

申请号：US15541998

申请日：2016-01-11

申请人： Mabimmune Diagnostics AG ,  Neurimmune Holding AG ,  University of Zurich

发明人： Chad BROKOPP ,  Jan GRIMM ,  Benoit COMBALUZIER ,  Mareike GOERANSON ,  Christine LOHMANN ,  Simon HOERSTRUP ,  Roger NITSCH

IPC分类号： C07K16/40 ,  G01N33/573 ,  A61K47/68 ,  C12N9/48 ,  C07K16/28 ,  G01N33/574

CPC分类号： C07K16/40 ,  A61K47/6871 ,  A61K2039/505 ,  C07K16/2878 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12N9/485 ,  C12Y304/14005 ,  G01N33/573 ,  G01N33/57492 ,  G01N2333/948 ,  G01N2800/224 ,  G01N2800/226 ,  G01N2800/323 ,  G01N2800/52

摘要： Provided are novel human-derived antibodies specific for Fibroblast Activation Protein (FAP), preferably capable of selectively inhibiting the enzymatic activity of FAP, as well as methods related thereto. In addition, methods of diagnosing and/or monitoring diseases and treatments thereof which are associated with FAP are provided. Assays and kits related to antibodies specific for FAP are also disclosed. The novel anti-FAP antibodies can be used in pharmaceutical and diagnostic compositions for FAP-targeted immunotherapy and diagnostics.

公开(公告)号：US20160052996A1

公开(公告)日：2016-02-25

申请号：US14758615

申请日：2014-01-02

申请人： NEURIMMUNE HOLDING AG ,  UNIVERSITY OF ZURICH

发明人： Jan GRIMM ,  Roland MARTIN ,  Benoit COMBALUZIER ,  Ivan JELCIC

IPC分类号： C07K16/08 ,  C12N7/00 ,  C07K14/005 ,  A61K39/42 ,  A61K45/06

CPC分类号： C07K16/084 ,  A61K39/42 ,  A61K45/06 ,  C07K14/005 ,  C07K16/081 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C12N7/00 ,  C12N2710/22022 ,  G01N33/56983 ,  G01N33/6893 ,  G01N2333/025

摘要： Provided are novel human-derived antibodies specifically recognizing polyomavirus polypeptides, preferably capable of binding to polyomaviruses of the type of JC virus (JCV) and/or BK virus (BKV) as well as methods related thereto. Furthermore, assays and kits related to antibodies specific for polyomaviruses, polyomavirus VP1 and or polyomavirus VP1 Virus-Like Particles (VLPs), preferably of the type of JCV and/or BKV, are disclosed. The human-derived antibodies as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for polyomavirus targeted immunotherapy and diagnostics.

摘要翻译： 提供了特异性识别多瘤病毒多肽的新型人源性抗体，优选能够结合JC病毒（JCV）和/或BK病毒（BKV）类型的多瘤病毒以及与之相关的方法。 此外，公开了与针对多瘤病毒，多瘤病毒VP1和/或多瘤病毒VP1病毒样颗粒（VLP），特别是JCV和/或BKV类型的抗体相关的测定和试剂盒。 人源抗体以及其结合片段，衍生物和变体可以用于用于多瘤病毒靶向免疫治疗和诊断的药物和诊断组合物中。

公开(公告)号：US20180179276A1

公开(公告)日：2018-06-28

申请号：US15125450

申请日：2015-03-12

申请人： Neurimmune Holding AG ,  University of Zurich

发明人： Jan GRIMM ,  Fabrice HEITZ ,  Fabian WIRTH ,  Tobias WELT

IPC分类号： C07K16/26 ,  A61K47/68 ,  A61K49/00 ,  A61P3/10 ,  A61K45/06 ,  A61K39/395 ,  A01K67/027

CPC分类号： C07K16/26 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0312 ,  A01K2267/0362 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6847 ,  A61K49/0008 ,  A61K2039/505 ,  A61P3/10 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

摘要： Described are molecules specifically binding to human islet amyloid polypeptide (hIAPP) also known as amylin, particularly human-derived antibodies as well as fragments, derivatives and variants thereof for antagonizing islet amyloid polypeptide (IAPP) induced β-cell damage and impaired glucose tolerance which are symptoms typically associated with diabetes mellitus type 2 (T2D).

公开(公告)号：US20200010567A1

公开(公告)日：2020-01-09

申请号：US16434654

申请日：2019-06-07

申请人： Neurimmune Holding AG

发明人： Fabio MONTRASIO ,  Jan GRIMM

IPC分类号： C07K16/44 ,  G01N33/68

摘要： Provided are novel human-derived dipeptide repeat (DPR) specific antibodies as well as synthetic variants and biotechnological derivatives thereof, preferably capable of binding C9ORF72 DPRs, as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for DPRs and DPR proteins such C9ORF72 DPRs are also disclosed. The antibody of the present invention can be used in pharmaceutical and diagnostic compositions for DPR protein-targeted immunotherapy and diagnostics.

公开(公告)号：US20170247471A1

公开(公告)日：2017-08-31

申请号：US15508343

申请日：2015-09-30

申请人： Neurimmune Holding AG

发明人： Fabio MONTRASIO ,  Jan GRIMM

IPC分类号： C07K16/44 ,  G01N33/68

CPC分类号： C07K16/44 ,  A61P25/28 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2800/2814

摘要： Provided are novel human-derived dipeptide repeat (DPR) specific antibodies as well as synthetic variants and biotechnological derivatives thereof, preferably capable of binding C9ORF72 DPRs, as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for DPRs and DPR proteins such C9ORF72 DPRs are also disclosed. The antibody of the present invention can be used in pharmaceutical and diagnostic compositions for DPR protein-targeted immunotherapy and diagnostics.

公开(公告)号：US20220332808A1

公开(公告)日：2022-10-20

申请号：US17810113

申请日：2022-06-30

申请人： Neurimmune Holding AG

发明人： Marcel MAIER ,  Jan GRIMM

IPC分类号： C07K16/18 ,  G01N33/68 ,  A61K39/395 ,  C07K14/47

摘要： Provided are novel human-derived anti-huntingtin (HTT) antibodies and biotechnological derivatives thereof, preferably capable of binding mutated and/or aggregated HTT species and or fragments thereof, as well as methods related thereto. The human-derived anti-HTT antibodies and biotechnological derivatives can be used in pharmaceutical and diagnostic compositions for HTT targeted immunotherapy of Huntington Disease and diagnosis thereof.