公开(公告)号：US10321866B2

公开(公告)日：2019-06-18

申请号：US14484605

申请日：2014-09-12

Applicant: NeuroPace, Inc.

Inventor： Benjamin D. Pless ,  Stephen T. Archer ,  Craig M. Baysinger ,  Barbara Gibb ,  Suresh Gurunathan ,  Bruce Kirkpatrick ,  Thomas K. Tcheng

IPC: A61B5/04 ,  A61B5/00 ,  A61B5/0476 ,  A61B5/0478

Abstract: Systems, methods and devices are disclosed for directing and focusing signals to the brain for neuromodulation and for directing and focusing signals or other energy from the brain for measurement, heat transfer and imaging. An aperture in the skull and/or a channel device implantable in the skull can be used to facilitate direction and focusing. Treatment and diagnosis of multiple neurological conditions may be facilitated with the disclosed systems, methods and devices.

公开(公告)号：US09186508B2

公开(公告)日：2015-11-17

申请号：US14059090

申请日：2013-10-21

Applicant: NeuroPace, Inc.

Inventor： Thomas K. Tcheng ,  Robert E. Fischell ,  Benjamin D. Pless

IPC: A61N1/36

CPC classification number: A61N1/36067 ,  A61N1/36135

Abstract: An implantable neurostimulator system for treating movement disorders includes a sensor, a detection subsystem capable of identifying episodes of a movement disorder by analyzing a signal received from the sensor, and a therapy subsystem capable of supplying therapeutic electrical stimulation to treat the movement disorder. The system treats movement disorders by detecting physiological conditions characteristic of an episode of symptoms of the movement disorder and selectively initiating therapy when such conditions are detected.

公开(公告)号：US20150112222A1

公开(公告)日：2015-04-23

申请号：US14525710

申请日：2014-10-28

Applicant: NeuroPace, Inc.

Inventor： Felice Sun ,  Benjamin D. Pless ,  Barbara Gibb

IPC: A61B5/00 ,  A61B5/0476

CPC classification number: A61B5/4812 ,  A61B5/01 ,  A61B5/0205 ,  A61B5/02438 ,  A61B5/026 ,  A61B5/04012 ,  A61B5/0452 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/11 ,  A61B5/1118 ,  A61B5/14551 ,  A61B5/4815 ,  A61B5/686 ,  A61N1/36082 ,  A61N1/36135 ,  G06F19/00

Abstract: Described here are implantable devices and methods for monitoring physiological information relating to sleep. The implantable devices are generally designed to include at least one sensor for sensing physiological information, a processor for processing the physiological information using low computational power to detect a sleep stage, and a battery. The detected sleep stage information may then be used to indicate sleep quality, identify or monitor a medical condition, or guide treatment thereof.

Abstract translation: 这里描述的是用于监测与睡眠相关的生理信息的可植入装置和方法。 可植入装置通常设计成包括用于感测生理信息的至少一个传感器，用于使用低计算能力处理生理信息以检测睡眠阶段的处理器以及电池。 然后可以使用检测到的睡眠阶段信息来指示睡眠质量，识别或监测医疗状况或指导治疗。

公开(公告)号：US09943690B2

公开(公告)日：2018-04-17

申请号：US15246351

申请日：2016-08-24

Applicant: NeuroPace, Inc.

Inventor： Benjamin D. Pless ,  Thomas K. Tcheng

IPC: A61N1/00 ,  A61N1/36 ,  A61M5/142 ,  A61N1/05 ,  A61B5/00 ,  A61B5/04 ,  A61B5/0476 ,  A61B5/07 ,  A61B5/021 ,  A61B5/026 ,  A61B5/0488 ,  A61B5/145

CPC classification number: A61N1/36135 ,  A61B5/0006 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/021 ,  A61B5/026 ,  A61B5/04012 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/076 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/4812 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/743 ,  A61M5/14276 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0539 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36078 ,  A61N1/36139

Abstract: An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.

公开(公告)号：US08805514B2

公开(公告)日：2014-08-12

申请号：US13783143

申请日：2013-03-01

Applicant: NeuroPace, Inc.

Inventor： Benjamin D. Pless ,  David R. Fischell ,  Barbara Gibb ,  Lisa Guzzo ,  Adrian R. M. Upton

IPC: A61N1/00

CPC classification number: A61B5/076 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/0478 ,  A61B5/0482 ,  A61B5/4094 ,  A61B5/686 ,  A61B5/742 ,  A61B5/7475 ,  A61N1/36064 ,  A61N1/36135 ,  A61N1/37252 ,  A61N1/37258 ,  A61N1/37282 ,  G06F19/00

Abstract: An interactive implantable medical device system includes an implantable medical device and a network-enabled external device capable of bi-directional communication and interaction with the implantable medical device. The external device is programmed to interact with other similarly-enabled devices. The system facilitates improved patient care by eliminating unnecessary geographic limitations on implantable medical device interrogation and programming, and by allowing patients, physicians, and other users to access medical records, history, and information and to receive status and care-related alerts and messages anywhere there is access to a communications network.

Abstract translation: 交互式可植入医疗装置系统包括能够与可植入医疗装置进行双向通信和交互的可植入医疗装置和能够启用网络的外部装置。 外部设备被编程为与其他类似启用的设备进行交互。 该系统通过消除对植入式医疗设备询问和编程的不必要的地理限制，以及允许患者，医生和其他用户访问医疗记录，历史和信息以及随时接收状态和护理相关的警报和消息来促进改善患者护理 可以访问通信网络。

公开(公告)号：US08538514B2

公开(公告)日：2013-09-17

申请号：US13733055

申请日：2013-01-02

Applicant: NeuroPace, Inc.

Inventor： Felice Sun ,  Benjamin D. Pless ,  Barbara Gibb

IPC: A61B5/048

CPC classification number: A61B5/4812 ,  A61B5/01 ,  A61B5/0205 ,  A61B5/02438 ,  A61B5/026 ,  A61B5/04012 ,  A61B5/0452 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/11 ,  A61B5/1118 ,  A61B5/14551 ,  A61B5/4815 ,  A61B5/686 ,  A61N1/36082 ,  A61N1/36135 ,  G06F19/00

Abstract: Described here are implantable devices and methods for monitoring physiological information relating to sleep. The implantable devices are generally designed to include at least one sensor for sensing physiological information, a processor for processing the physiological information using low computational power to detect a sleep stage, and a battery. The detected sleep stage information may then be used to indicate sleep quality, identify or monitor a medical condition, or guide treatment thereof.

公开(公告)号：US09451891B2

公开(公告)日：2016-09-27

申请号：US14562135

申请日：2014-12-05

Applicant: NeuroPace, Inc.

Inventor： Benjamin D. Pless ,  Thomas K. Tcheng

IPC: A61N1/00 ,  A61B5/04 ,  A61M5/142 ,  A61N1/36 ,  A61B5/0476 ,  A61B5/07 ,  A61N1/05 ,  A61B5/00

CPC classification number: A61N1/36135 ,  A61B5/0006 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/021 ,  A61B5/026 ,  A61B5/04012 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/076 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/4812 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/743 ,  A61M5/14276 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0539 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36078 ,  A61N1/36139

Abstract: An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.

公开(公告)号：US08805520B2

公开(公告)日：2014-08-12

申请号：US14043599

申请日：2013-10-01

Applicant: NeuroPace, Inc.

Inventor： Benjamin D. Pless ,  Michael Sasha John

IPC: A61N1/00

CPC classification number: A61N1/36071 ,  A61F7/007 ,  A61F2007/0075 ,  A61M5/1723 ,  A61M2005/1726 ,  A61N1/36135 ,  A61N2/006 ,  A61N5/0622

Abstract: An implantable neurostimulator system for treating pain includes scheduled and responsive therapy capabilities including responsive stimulation applied to the brain and peripheral sections of the nervous system. Methods for treating chronic nociceptive, neuropathic, and psychogenic pain employ an inventive system to advantageously reduce multiple symptoms and components of pain and to address underlying causes of pain.

Abstract translation: 用于治疗疼痛的可植入神经刺激器系统包括计划和响应的治疗能力，包括应用于神经系统的大脑和周边部分的响应刺激。 用于治疗慢性伤害感受神经病和心理性疼痛的方法采用本发明的系统来有利地减少疼痛的多种症状和成分并解​​决潜在的疼痛原因。

公开(公告)号：US09878160B2

公开(公告)日：2018-01-30

申请号：US15246315

申请日：2016-08-24

Applicant: NeuroPace, Inc.

Inventor： Benjamin D. Pless ,  Thomas K. Tcheng

IPC: A61N1/00 ,  A61N1/36 ,  A61M5/142 ,  A61N1/05 ,  A61B5/00 ,  A61B5/04 ,  A61B5/0476 ,  A61B5/07 ,  A61B5/021 ,  A61B5/026 ,  A61B5/0488 ,  A61B5/145

CPC classification number: A61N1/36135 ,  A61B5/0006 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/021 ,  A61B5/026 ,  A61B5/04012 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/076 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/4812 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/743 ,  A61M5/14276 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0539 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36078 ,  A61N1/36139

Abstract: An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.

公开(公告)号：US09302111B2

公开(公告)日：2016-04-05

申请号：US14282983

申请日：2014-05-20

Applicant: NeuroPace, Inc.

Inventor： Michael Sasha John ,  Benjamin D. Pless ,  Brett Wingeier

IPC: A61N1/36 ,  A61B5/1455 ,  A61F7/00 ,  A61N2/02 ,  A61N5/06 ,  A61N7/00 ,  A61B5/02 ,  A61F7/12 ,  A61B5/00 ,  A61B5/0476 ,  A61B5/1459 ,  A61B8/06

CPC classification number: A61N1/36139 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0476 ,  A61B5/14553 ,  A61B5/1459 ,  A61B5/4094 ,  A61B5/6868 ,  A61B5/7217 ,  A61B8/06 ,  A61B8/12 ,  A61B8/488 ,  A61F7/00 ,  A61F7/12 ,  A61N1/36057 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/36135 ,  A61N2/006 ,  A61N2/02 ,  A61N5/0622 ,  A61N7/00 ,  A61N2007/0043

Abstract: A system includes an implantable neurostimulator device capable of modulating cerebral blood flow to treat epilepsy and other neurological disorders. In one embodiment, the system is capable of modulating cerebral blood flow (also referred to as cerebral perfusion) in response to measurements and other observed conditions. Perfusion may be increased or decreased by systems and methods according to the invention as clinically required.

Abstract translation: 一种系统包括能够调节脑血流量以治疗癫痫和其他神经障碍的可植入神经刺激器装置。 在一个实施方案中，系统能够响应于测量和其他观察到的条件而调节脑血流量（也称为脑灌注）。 根据临床要求的根据本发明的系统和方法可以增加或减少灌注。