公开(公告)号：US11064926B2

公开(公告)日：2021-07-20

申请号：US15817160

申请日：2017-11-17

Applicant: NeuroPace, Inc.

Inventor： Tara L. Crowder ,  Brett M. Wingeier ,  Martha J. Morrell ,  Felice Sun ,  Thomas Tcheng

IPC: A61B5/00 ,  A61B5/24 ,  A61B5/377 ,  A61B5/145 ,  A61B5/1455

Abstract: Systems and methods rely on feedback from an active medical device or devices (e.g., neurostimulator coupled to sensing and stimulation elements such as electrodes) to assess the effectiveness of a patient's drug regimen. Such reliance may include analyzing characteristics in physiological data acquired by the medical device(s), for example, in the form of responses evoked from the patient by electrical stimulation waveforms. Systems and methods further involved adjusting one or more parameters according to which a combination therapy consisting of at least a drug regimen and an electrical stimulation therapy are delivered to a patient, in an effort to optimize the therapeutic effect of the combination. The adjustments may be automatically by one or more implanted or external hosts working together or alone, and/or with the input of a physician.

公开(公告)号：US20130072810A1

公开(公告)日：2013-03-21

申请号：US13679925

申请日：2012-11-16

Applicant: NeuroPace, Inc.

Inventor： Brett M. Wingeier ,  Thomas K. Tcheng

IPC: A61B5/0476

CPC classification number: A61B5/0476 ,  A61B5/0031 ,  A61B5/048 ,  A61B5/0484 ,  A61B5/076 ,  A61B5/16 ,  A61B5/4094 ,  A61B5/7257

Abstract: A system and method for detecting and predicting neurological events with an implantable device uses a relatively low-power central processing unit in connection with signal processing circuitry to identify features (including half waves) and calculate window-based characteristics (including line lengths and areas under the curve of the waveform) in one or more electrographic signals received from a patient's brain. The features and window-based characteristics are employed within the framework of a programmable finite state machine to identify patterns and sequences in and across the electrographic signals, facilitating early and reliable detection and prediction of complex spatiotemporal neurological events in real time, and enabling responsive action by the implantable device.

Abstract translation: 使用可植入装置检测和预测神经病学的系统和方法使用与信号处理电路相关联的相对低功率的中央处理单元来识别特征（包括半波）并计算基于窗口的特征（包括线路长度和面积 波形的曲线）在从患者的大脑接收的一个或多个电描记信号中。 在可编程有限状态机的框架内采用特征和基于窗口的特征，以识别和跨越电图像信号的图案和序列，便于实时地对复杂的时空神经事件进行早期可靠的检测和预测，并且能够实现响应动作 通过可植入装置。

公开(公告)号：US20240306989A1

公开(公告)日：2024-09-19

申请号：US18674684

申请日：2024-05-24

Applicant: NeuroPace, Inc.

Inventor： Tara L. Crowder ,  Brett M. Wingeier ,  Martha J. Morrell ,  Felice Sun ,  Thomas Tcheng

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/24 ,  A61B5/377

CPC classification number: A61B5/4848 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/24 ,  A61B5/377 ,  A61B5/0022 ,  A61B5/14539 ,  A61B5/14553 ,  A61B5/4082 ,  A61B5/4094

Abstract: Systems and methods rely on feedback from an active medical device or devices (e.g., neurostimulator coupled to sensing and stimulation elements such as electrodes) to assess the effectiveness of a patient's drug regimen. Such reliance may include analyzing characteristics in physiological data acquired by the medical device(s), for example, in the form of responses evoked from the patient by electrical stimulation waveforms. Systems and methods further involved adjusting one or more parameters according to which a combination therapy consisting of at least a drug regimen and an electrical stimulation therapy are delivered to a patient, in an effort to optimize the therapeutic effect of the combination. The adjustments may be automatically by one or more implanted or external hosts working together or alone, and/or with the input of a physician.

公开(公告)号：US12029581B2

公开(公告)日：2024-07-09

申请号：US17346944

申请日：2021-06-14

Applicant: NeuroPace, Inc.

Inventor： Tara L. Crowder ,  Brett M. Wingeier ,  Martha J. Morrell ,  Felice Sun ,  Thomas Tcheng

IPC: A61B5/00 ,  A61B5/24 ,  A61B5/377 ,  A61B5/145 ,  A61B5/1455

CPC classification number: A61B5/4848 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/24 ,  A61B5/377 ,  A61B5/0022 ,  A61B5/14539 ,  A61B5/14553 ,  A61B5/4082 ,  A61B5/4094

Abstract: Systems and methods rely on feedback from an active medical device or devices (e.g., neurostimulator coupled to sensing and stimulation elements such as electrodes) to assess the effectiveness of a patient's drug regimen. Such reliance may include analyzing characteristics in physiological data acquired by the medical device(s), for example, in the form of responses evoked from the patient by electrical stimulation waveforms. Systems and methods further involved adjusting one or more parameters according to which a combination therapy consisting of at least a drug regimen and an electrical stimulation therapy are delivered to a patient, in an effort to optimize the therapeutic effect of the combination. The adjustments may be automatically by one or more implanted or external hosts working together or alone, and/or with the input of a physician.

公开(公告)号：US09314182B2

公开(公告)日：2016-04-19

申请号：US13679925

申请日：2012-11-16

Applicant: NeuroPace, Inc.

Inventor： Brett M. Wingeier ,  Thomas K. Tcheng

IPC: A61B5/04 ,  A61B5/0476 ,  A61B5/048 ,  A61B5/0484 ,  A61B5/00 ,  A61B5/16 ,  A61B5/07

CPC classification number: A61B5/0476 ,  A61B5/0031 ,  A61B5/048 ,  A61B5/0484 ,  A61B5/076 ,  A61B5/16 ,  A61B5/4094 ,  A61B5/7257

Abstract: A system and method for detecting and predicting neurological events with an implantable device uses a relatively low-power central processing unit in connection with signal processing circuitry to identify features (including half waves) and calculate window-based characteristics (including line lengths and areas under the curve of the waveform) in one or more electrographic signals received from a patient's brain. The features and window-based characteristics are employed within the framework of a programmable finite state machine to identify patterns and sequences in and across the electrographic signals, facilitating early and reliable detection and prediction of complex spatiotemporal neurological events in real time, and enabling responsive action by the implantable device.

公开(公告)号：US20180085015A1

公开(公告)日：2018-03-29

申请号：US15817160

申请日：2017-11-17

Applicant: NeuroPace, Inc.

Inventor： Tara L. Crowder ,  Brett M. Wingeier ,  Martha J. Morrell ,  Felice Sun ,  Thomas Tcheng

IPC: A61B5/04 ,  A61B5/00 ,  A61B5/0484 ,  A61B5/1455 ,  A61B5/145

CPC classification number: A61B5/04 ,  A61B5/0002 ,  A61B5/0022 ,  A61B5/04001 ,  A61B5/0484 ,  A61B5/14539 ,  A61B5/14553 ,  A61B5/4082 ,  A61B5/4094 ,  A61B5/4848

Abstract: Systems and methods rely on feedback from an active medical device or devices (e.g., neurostimulator coupled to sensing and stimulation elements such as electrodes) to assess the effectiveness of a patient's drug regimen. Such reliance may include analyzing characteristics in physiological data acquired by the medical device(s), for example, in the form of responses evoked from the patient by electrical stimulation waveforms. Systems and methods further involved adjusting one or more parameters according to which a combination therapy consisting of at least a drug regimen and an electrical stimulation therapy are delivered to a patient, in an effort to optimize the therapeutic effect of the combination. The adjustments may be automatically by one or more implanted or external hosts working together or alone, and/or with the input of a physician.

公开(公告)号：US20210298654A1

公开(公告)日：2021-09-30

申请号：US17346944

申请日：2021-06-14

Applicant: NeuroPace, Inc.

Inventor： Tara L. Crowder ,  Brett M. Wingeier ,  Martha J. Morrell ,  Felice Sun ,  Thomas Tcheng

IPC: A61B5/24 ,  A61B5/00 ,  A61B5/377

Abstract: Systems and methods rely on feedback from an active medical device or devices (e.g., neurostimulator coupled to sensing and stimulation elements such as electrodes) to assess the effectiveness of a patient's drug regimen. Such reliance may include analyzing characteristics in physiological data acquired by the medical device(s), for example, in the form of responses evoked from the patient by electrical stimulation waveforms. Systems and methods further involved adjusting one or more parameters according to which a combination therapy consisting of at least a drug regimen and an electrical stimulation therapy are delivered to a patient, in an effort to optimize the therapeutic effect of the combination. The adjustments may be automatically by one or more implanted or external hosts working together or alone, and/or with the input of a physician.

公开(公告)号：US08771194B2

公开(公告)日：2014-07-08

申请号：US13714387

申请日：2012-12-13

Applicant: NeuroPace, Inc.

Inventor： Michael S. John ,  Benjamin D. Pless ,  Brett M. Wingeier

IPC: A61B5/027 ,  A61B5/02 ,  A61B8/06

CPC classification number: A61N1/36139 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0476 ,  A61B5/14553 ,  A61B5/1459 ,  A61B5/4094 ,  A61B5/6868 ,  A61B5/7217 ,  A61B8/06 ,  A61B8/12 ,  A61B8/488 ,  A61F7/00 ,  A61F7/12 ,  A61N1/36057 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/36135 ,  A61N2/006 ,  A61N2/02 ,  A61N5/0622 ,  A61N7/00 ,  A61N2007/0043

Abstract: A system including an implantable neurostimulator device capable of modulating cerebral blood flow to treat epilepsy and other neurological disorders. In one embodiment, the system is capable of modulating cerebral blood flow (also referred to as cerebral perfusion) in response to measurements and other observed conditions. Perfusion may be increased or decreased by systems and methods according to the invention as clinically required.

Abstract translation: 一种包括能够调节脑血流以治疗癫痫和其他神经障碍的可植入神经刺激器装置的系统。 在一个实施方案中，系统能够响应于测量和其他观察到的条件而调节脑血流量（也称为脑灌注）。 根据临床要求的根据本发明的系统和方法可以增加或减少灌注。