公开(公告)号：US09801820B2

公开(公告)日：2017-10-31

申请号：US14441970

申请日：2013-11-08

申请人： New Jersey Institute of Technology

发明人： Daniel To ,  Rajesh Dave ,  Catharina Knieke ,  Ecevit A. Bilgili ,  Mohammed A. Azad

IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K31/216 ,  B05D1/22 ,  A61K9/50

CPC分类号： A61K9/1676 ,  A61K9/14 ,  A61K9/141 ,  A61K9/145 ,  A61K9/1611 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1682 ,  A61K9/1694 ,  A61K9/20 ,  A61K9/2077 ,  A61K9/501 ,  A61K9/5078 ,  A61K9/5089 ,  A61K31/216 ,  B05D1/22

摘要： A composite particle including a core with at least one carrier material; a fluidizing material layer on the surface of the core; and an outer layer comprising nanoparticles of an ingestible material distributed in at least one matrix-forming material. A process of making the composite particles includes the steps of dry coating carrier particles with a fluidizing material; preparing a suspension of nanoparticles of an ingestible material distributed in a matrix-forming material; and fluid bed coating the carrier particles with the suspension. The process and products provide quick dissolving composite particles which can be used for delivery of poorly water soluble ingestible materials in suitable dosage forms. The process of the invention reduces or prevents particle agglomeration during fabrication of the composite particles to enable delivery and quick redispersion of nanoparticles of the ingestible material from a dosage form.

公开(公告)号：US20150297521A1

公开(公告)日：2015-10-22

申请号：US14441970

申请日：2013-11-08

申请人： New Jersey Institute of Technology

发明人： Daniel To ,  Rajesh Dave ,  Catharina Knieke ,  Ecevit A. Bilgili ,  Mohammed A. Azad

IPC分类号： A61K9/16 ,  B05D1/22 ,  A61K31/216

CPC分类号： A61K9/1676 ,  A61K9/14 ,  A61K9/141 ,  A61K9/145 ,  A61K9/1611 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1682 ,  A61K9/1694 ,  A61K9/20 ,  A61K9/2077 ,  A61K9/501 ,  A61K9/5078 ,  A61K9/5089 ,  A61K31/216 ,  B05D1/22

摘要： A composite particle including a core with at least one carrier material; a fluidizing material layer on the surface of the core; and an outer layer comprising nanoparticles of an ingestible material distributed in at least one matrix-forming material. A process of making the composite particles includes the steps of dry coating carrier particles with a fluidizing material; preparing a suspension of nanoparticles of an ingestible material distributed in a matrix-forming material; and fluid bed coating the carrier particles with the suspension. The process and products provide quick dissolving composite particles which can be used for delivery of poorly water soluble ingestible materials in suitable dosage forms. The process of the invention reduces or prevents particle agglomeration during fabrication of the composite particles to enable delivery and quick redispersion of nanoparticles of the ingestible material from a dosage form.

摘要翻译： 包括具有至少一种载体材料的芯的复合颗粒; 在芯的表面上的流化材料层; 以及包含分布在至少一种基质形成材料中的可摄取材料的纳米颗粒的外层。 制造复合颗粒的方法包括用流化材料干燥涂布载体颗粒的步骤; 制备分布在基质形成材料中的可摄取材料的纳米颗粒的悬浮液; 并且将载体颗粒与悬浮液一起涂覆的流化床。 该方法和产品提供快速溶解的复合颗粒，其可用于以合适的剂型递送水溶性差的可摄取材料。 本发明的方法在制备复合颗粒期间降低或防止颗粒聚集，以使得能够从剂型中输送并快速再分散可摄取材料的纳米颗粒。