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    System and Method for Fabrication of Uniform Polymer Films Containing Nano and Micro Particles via Continuous Drying Process
    1.
    发明申请
    System and Method for Fabrication of Uniform Polymer Films Containing Nano and Micro Particles via Continuous Drying Process 审中-公开
    通过连续干燥工艺制备含有纳米微粒子的均匀聚合物膜的系统和方法

    公开(公告)号：US20160022599A1

    公开(公告)日：2016-01-28

    申请号：US14777191

    申请日：2014-03-17

    申请人： NEW JERSEY INSTITUTE OF TECHNOLOGY

    发明人： Rajesh N. Dave ,  Ramani Susarla ,  Boris Khusid ,  Anagha A. Bhakay ,  Ecevit A. Bilgili ,  Fernando Muzzio

    IPC分类号： A61K9/70 ,  A61K47/38 ,  B29C39/14 ,  A61K31/216 ,  B29C39/00 ,  A61K31/343 ,  A61K47/32

    CPC分类号： A61K9/7007 ,  A61F13/00063 ,  A61K9/0056 ,  A61K9/006 ,  A61K31/216 ,  A61K31/343 ,  A61K47/32 ,  A61K47/38 ,  B29C39/003 ,  B29C39/14 ,  B29L2007/008

    摘要： The present disclosure provides improved stripfilm based pharmaceutical products (e.g., for enhancing dissolution and bioavailability). More particularly, the present disclosure provides improved systems/methods for fabricating stripfilm based pharmaceutical products by utilizing higher viscosity film forming precursors and drying methods that accomplish improved/faster drying and provide improved/excellent content uniformity of active pharmaceutical agents in the stripfilm based pharmaceutical products. Exemplary systems/methods advantageously use high viscosity, bio-compatible polymeric precursors, (optional use of surface modified drug powders), and convective drying for fabrication of thin films loaded with nano and/or micro sized particles of poorly water-soluble active pharmaceutical ingredients (APIs) to achieve improved active content uniformity and very fast dissolution from poorly water soluble actives, while accomplishing fast drying during the fabrication process. The present disclosure provides for the fast drying (e.g., via low temperature forced convection) of biocompatible polymer films loaded with poorly water-soluble drug nano-particles.

    摘要翻译： 本公开提供了改进的基于薄膜的药物产品（例如，用于增强溶解和生物利用度）。 更具体地，本公开提供了通过利用更高粘度的成膜前体和干燥方法来制造基于薄膜的药物产品的改进的系统/方法，所述前体和干燥方法实现改进/更快的干燥，并且提供基于带状薄膜的药物产品中活性药剂的改进/优异的含量均匀性 。 示例性系统/方法有利地使用高粘度，生物相容性聚合物前体（任选使用表面改性药物粉末）和对流干燥以制备装载有水溶性差的活性药物成分的纳米和/或微尺寸颗粒的薄膜 （API），以实现改善的活性成分均匀性和非常快的水溶性活性物质的溶出，同时在制造过程中实现快速干燥。 本公开内容提供了装载有不良水溶性药物纳米颗粒的生物相容性聚合物膜的快速干燥（例如通过低温强制对流）。

    Pharmaceutical Core-Shell Composite Powder and Processes for Making the Same
    4.
    发明申请
    Pharmaceutical Core-Shell Composite Powder and Processes for Making the Same 有权
    制药芯壳复合粉及其制作方法

    公开(公告)号：US20150297521A1

    公开(公告)日：2015-10-22

    申请号：US14441970

    申请日：2013-11-08

    申请人： New Jersey Institute of Technology

    发明人： Daniel To ,  Rajesh Dave ,  Catharina Knieke ,  Ecevit A. Bilgili ,  Mohammed A. Azad

    IPC分类号： A61K9/16 ,  B05D1/22 ,  A61K31/216

    CPC分类号： A61K9/1676 ,  A61K9/14 ,  A61K9/141 ,  A61K9/145 ,  A61K9/1611 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1682 ,  A61K9/1694 ,  A61K9/20 ,  A61K9/2077 ,  A61K9/501 ,  A61K9/5078 ,  A61K9/5089 ,  A61K31/216 ,  B05D1/22

    摘要： A composite particle including a core with at least one carrier material; a fluidizing material layer on the surface of the core; and an outer layer comprising nanoparticles of an ingestible material distributed in at least one matrix-forming material. A process of making the composite particles includes the steps of dry coating carrier particles with a fluidizing material; preparing a suspension of nanoparticles of an ingestible material distributed in a matrix-forming material; and fluid bed coating the carrier particles with the suspension. The process and products provide quick dissolving composite particles which can be used for delivery of poorly water soluble ingestible materials in suitable dosage forms. The process of the invention reduces or prevents particle agglomeration during fabrication of the composite particles to enable delivery and quick redispersion of nanoparticles of the ingestible material from a dosage form.

    摘要翻译： 包括具有至少一种载体材料的芯的复合颗粒; 在芯的表面上的流化材料层; 以及包含分布在至少一种基质形成材料中的可摄取材料的纳米颗粒的外层。 制造复合颗粒的方法包括用流化材料干燥涂布载体颗粒的步骤; 制备分布在基质形成材料中的可摄取材料的纳米颗粒的悬浮液; 并且将载体颗粒与悬浮液一起涂覆的流化床。 该方法和产品提供快速溶解的复合颗粒，其可用于以合适的剂型递送水溶性差的可摄取材料。 本发明的方法在制备复合颗粒期间降低或防止颗粒聚集，以使得能够从剂型中输送并快速再分散可摄取材料的纳米颗粒。