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    Method of preparing red blood cell and platelet products
    1.
    发明授权
    Method of preparing red blood cell and platelet products 有权
    制备红细胞和血小板产品的方法

    公开(公告)号：US09394518B2

    公开(公告)日：2016-07-19

    申请号：US14598938

    申请日：2015-01-16

    申请人： New York Blood Center, Inc.

    发明人： Beth H. Shaz ,  Christopher D. Hillyer

    IPC分类号： A61K35/14 ,  C12N5/078 ,  A61M1/02 ,  A01N1/02

    CPC分类号： C12N5/0641 ,  A01N1/02 ,  A01N1/021 ,  A01N1/0226 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K35/19 ,  A61M1/0272 ,  A61M1/342 ,  A61M1/3496 ,  A61M2202/0429 ,  A61M2202/20 ,  C12N5/0644

    摘要： This disclosure provides methods for preparing both a red blood cell (RBC)-containing product and a platelet-containing product from a plurality of blood units. The method comprises leukoreducing a plurality of blood units, separating RBCs, platelets, and plasma from the units to form leukoreduced blood components, pooling the leukoreduced RBC components; pooling the leukoreduced platelet components, treating the pooled components to inactivate one or more pathogens, adding a storage solution to components, dividing the pooled leukoreduced RBCs into a plurality of RBC-containing product units, each having a uniform number of RBCs, and dividing the pooled leukoreduced platelets into a plurality of platelet-containing product units, each having a uniform number of platelets.

    摘要翻译： 本公开提供了制备来自多个血液单元的含红细胞（RBC）的产物和含血小板的产品的方法。 该方法包括白细胞减少多个血液单元，从该单元分离RBC，血小板和血浆以形成白细胞减少的血液成分，汇集白细胞减少的RBC组分; 汇集白细胞减少的血小板成分，处理汇集的组分以灭活一种或多种病原体，向组分中加入储存溶液，将合并的白细胞减少的红细胞分成多个含有RBC的产物单元，每个RBC含有均一数目的RBC， 汇集的白细胞减少的血小板分成多个含血小板的产品单元，每个产品单元具有均匀数量的血小板。

    Component Preparation System
    2.
    发明申请
    Component Preparation System 有权
    组分制备系统

    公开(公告)号：US20150118109A1

    公开(公告)日：2015-04-30

    申请号：US14561138

    申请日：2014-12-04

    申请人： New York Blood Center, Inc.

    发明人： Christopher D. Hillyer ,  Beth H. Shaz

    IPC分类号： A61M1/38

    CPC分类号： A61M1/38 ,  A61M1/02 ,  A61M1/0281 ,  A61M2205/12 ,  A61M2205/75

    摘要： Disclosed herein are centrifuge-free self-contained systems for aseptically separating components of whole blood comprising at least one cassette for receiving whole blood; at least one red blood cell exclusion filter; at least one leukocyte reduction filters; at least one platelet exclusion filter; a plurality of product cassettes; and optionally a plurality of pumps and valves; and wherein the filters, pumps, valves, and cassettes are fluidly connected by tubing and the system does not include a centrifuge. Also disclosed are methods for obtaining blood components using the system.

    摘要翻译： 本文公开了用于无菌分离全血的组分的无离心自包含系统，其包括用于接收全血的至少一个盒; 至少一个红细胞排除滤器; 至少一种白细胞还原过滤器; 至少一个血小板排除过滤器; 多个产品盒; 和可选的多个泵和阀; 并且其中过滤器，泵，阀和盒通过管道流体连接，并且系统不包括离心机。 还公开了使用该系统获得血液成分的方法。

    Method of Blood Pooling and Storage
    8.
    发明申请
    Method of Blood Pooling and Storage 有权
    血液储存方法

    公开(公告)号：US20150125847A1

    公开(公告)日：2015-05-07

    申请号：US14598938

    申请日：2015-01-16

    申请人： New York Blood Center, Inc.

    发明人： Beth H. Shaz ,  Christopher D. Hillyer

    IPC分类号： C12N5/078 ,  A01N1/02 ,  A61M1/02

    CPC分类号： C12N5/0641 ,  A01N1/02 ,  A01N1/021 ,  A01N1/0226 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K35/19 ,  A61M1/0272 ,  A61M1/342 ,  A61M1/3496 ,  A61M2202/0429 ,  A61M2202/20 ,  C12N5/0644

    摘要： The disclosure provides methods of making a cell-containing product having a uniform amount of cells therein. The method comprises pooling red blood cells from a plurality of blood units, and inactivating any pathogen contained therein. A storage solution added to the cellular component results in a cell-containing product that is essentially pathogen and white blood cell free and has an extended shelf life of about 42 to about 100 days. The cell-containing product is further divided into units which comprise a uniform dose of RBCs per unit.

    摘要翻译： 本公开提供了制备其中具有均匀量的细胞的含细胞产物的方法。 所述方法包括从多个血液单元汇集红细胞，并灭活其中所含的任何病原体。 添加到细胞组分中的储存溶液导致基本上是病原体和无白血球的含细胞产物，并且具有约42至约100天的延长的保质期。 含细胞的产物进一步分为每单位含有均匀剂量的RBC的单位。

    Component preparation system
    10.
    发明授权
    Component preparation system 有权
    组分制备系统

    公开(公告)号：US09480786B2

    公开(公告)日：2016-11-01

    申请号：US14561138

    申请日：2014-12-04

    申请人： New York Blood Center, Inc.

    发明人： Christopher D. Hillyer ,  Beth H. Shaz

    IPC分类号： B01D37/00 ,  A61M1/38 ,  A61M1/02

    CPC分类号： A61M1/38 ,  A61M1/02 ,  A61M1/0281 ,  A61M2205/12 ,  A61M2205/75

    摘要： Disclosed herein are centrifuge-free self-contained systems for aseptically separating components of whole blood comprising at least one cassette for receiving whole blood; at least one red blood cell exclusion filter; at least one leukocyte reduction filters; at least one platelet exclusion filter; a plurality of product cassettes; and optionally a plurality of pumps and valves; and wherein the filters, pumps, valves, and cassettes are fluidly connected by tubing and the system does not include a centrifuge. Also disclosed are methods for obtaining blood components using the system.

    摘要翻译： 本文公开了用于无菌分离全血的组分的无离心自包含系统，其包括用于接收全血的至少一个盒; 至少一个红细胞排除滤器; 至少一种白细胞还原过滤器; 至少一个血小板排除过滤器; 多个产品盒; 和可选的多个泵和阀; 并且其中过滤器，泵，阀和盒通过管道流体连接，并且系统不包括离心机。 还公开了使用该系统获得血液成分的方法。