公开(公告)号：US09474739B2

公开(公告)日：2016-10-25

申请号：US14615227

申请日：2015-02-05

申请人： NEWRON PHARMACEUTICALS S.P.A.

发明人： Piero Melloni ,  Alessandra Restivo ,  Emanuela Izzo ,  Simona Francisconi ,  Elena Colombo ,  Cibele Sabido-David

IPC分类号： A61K31/165 ,  A61K31/137 ,  A61P1/00 ,  A61K31/381 ,  C07C237/08 ,  C07C317/28 ,  C07C323/25 ,  C07C327/42 ,  C07D295/182 ,  A61K31/40 ,  A61K31/4515 ,  A61K31/519 ,  A61K31/5513 ,  C07C237/06 ,  C07D207/16 ,  C07D333/20 ,  C07C237/20 ,  C07C321/26 ,  C07C327/44

CPC分类号： A61K31/381 ,  A61K31/137 ,  A61K31/165 ,  A61K31/40 ,  A61K31/4515 ,  A61K31/519 ,  A61K31/5513 ,  C07C237/06 ,  C07C237/08 ,  C07C237/20 ,  C07C317/28 ,  C07C321/26 ,  C07C323/25 ,  C07C327/42 ,  C07C327/44 ,  C07D207/16 ,  C07D295/182 ,  C07D333/20

摘要： Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives of formula (I) wherein X, Y, Z, R, R1, R2, R3, R′3 R4, R5, R6, R7 have the meanings defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.

公开(公告)号：US09474738B2

公开(公告)日：2016-10-25

申请号：US14615176

申请日：2015-02-05

申请人： NEWRON PHARMACEUTICALS S.P.A.

发明人： Piero Melloni ,  Alessandra Restivo ,  Emanuela Izzo ,  Simona Francisconi ,  Elena Colombo ,  Cibele Sabido-David

IPC分类号： A61K31/165 ,  A61K31/137 ,  A61P13/00 ,  A61K31/381 ,  C07C237/08 ,  C07C317/28 ,  C07C323/25 ,  C07C327/42 ,  C07D295/182 ,  A61K31/40 ,  A61K31/4515 ,  A61K31/519 ,  A61K31/5513 ,  C07C237/06 ,  C07D207/16 ,  C07D333/20 ,  C07C237/20 ,  C07C321/26 ,  C07C327/44

CPC分类号： A61K31/381 ,  A61K31/137 ,  A61K31/165 ,  A61K31/40 ,  A61K31/4515 ,  A61K31/519 ,  A61K31/5513 ,  C07C237/06 ,  C07C237/08 ,  C07C237/20 ,  C07C317/28 ,  C07C321/26 ,  C07C323/25 ,  C07C327/42 ,  C07C327/44 ,  C07D207/16 ,  C07D295/182 ,  C07D333/20

摘要： Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives of formula (I) wherein X, Y, Z, R, R1, R2, R3, R′3 R4, R5, R6, R7 have the meanings defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.

公开(公告)号：US20150157601A1

公开(公告)日：2015-06-11

申请号：US14615227

申请日：2015-02-05

申请人： NEWRON PHARMACEUTICALS S.P.A.

发明人： Piero Melloni ,  Alessandra Restivo ,  Emanuela Izzo ,  Simona Francisconi ,  Elena Colombo ,  Cibele Sabido-David

IPC分类号： A61K31/381 ,  A61K31/165

CPC分类号： A61K31/381 ,  A61K31/137 ,  A61K31/165 ,  A61K31/40 ,  A61K31/4515 ,  A61K31/519 ,  A61K31/5513 ,  C07C237/06 ,  C07C237/08 ,  C07C237/20 ,  C07C317/28 ,  C07C321/26 ,  C07C323/25 ,  C07C327/42 ,  C07C327/44 ,  C07D207/16 ,  C07D295/182 ,  C07D333/20

摘要： Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives of formula (I) wherein X, Y, Z, R, R1, R2, R3, R′3 R4, R5, R6, R7 have the meanings defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.

公开(公告)号：US09051240B2

公开(公告)日：2015-06-09

申请号：US13794555

申请日：2013-03-11

申请人： Newron Pharmaceuticals S.P.A.

发明人： Piero Melloni ,  Alessandra Restivo ,  Emanuela Izzo ,  Simona Francisconi ,  Elena Colombo ,  Cibele Sabido-David

IPC分类号： A61K31/165 ,  C07C237/08 ,  C07C233/05 ,  C07C233/65 ,  A61P25/00 ,  C07C237/20 ,  C07C317/28 ,  C07C323/25 ,  C07C327/42 ,  C07D295/182 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4515 ,  A61K31/519 ,  A61K31/5513 ,  C07C237/06 ,  C07D207/16 ,  C07D333/20 ,  C07C321/26 ,  C07C327/44

CPC分类号： A61K31/381 ,  A61K31/137 ,  A61K31/165 ,  A61K31/40 ,  A61K31/4515 ,  A61K31/519 ,  A61K31/5513 ,  C07C237/06 ,  C07C237/08 ,  C07C237/20 ,  C07C317/28 ,  C07C321/26 ,  C07C323/25 ,  C07C327/42 ,  C07C327/44 ,  C07D207/16 ,  C07D295/182 ,  C07D333/20

摘要： Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing them are useful as sodium and/or calcium channel modulators for preventing, alleviating and curing pathologies wherein the above mechanisms play a pathological role. The compounds may be particularly useful for the prevention, alleviation, and curing of, for example, neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases.

摘要翻译： 取代的2- [2-（苯基）乙基氨基]烷酰胺衍生物，其药学上可接受的盐和含有它们的药物组合物可用作用于预防，减轻和治愈其中上述机制发挥病理作用的病症的钠和/或钙通道调节剂。 这些化合物可能特别可用于预防，减轻和治愈例如神经，认知，精神，炎症，泌尿生殖和胃肠道疾病。

公开(公告)号：US20150157600A1

公开(公告)日：2015-06-11

申请号：US14615176

申请日：2015-02-05

申请人： NEWRON PHARMACEUTICALS S.P.A.

发明人： Piero Melloni ,  Alessandra Restivo ,  Emanuela Izzo ,  Simona Francisconi ,  Elena Colombo ,  Cibele Sabido-David

IPC分类号： A61K31/381 ,  A61K31/137 ,  A61K31/165

CPC分类号： A61K31/381 ,  A61K31/137 ,  A61K31/165 ,  A61K31/40 ,  A61K31/4515 ,  A61K31/519 ,  A61K31/5513 ,  C07C237/06 ,  C07C237/08 ,  C07C237/20 ,  C07C317/28 ,  C07C321/26 ,  C07C323/25 ,  C07C327/42 ,  C07C327/44 ,  C07D207/16 ,  C07D295/182 ,  C07D333/20

摘要： Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives of formula (I) wherein X, Y, Z, R, R1, R2, R3, R′3 R4, R5, R6, R7 have the meanings defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.

摘要翻译： 其中X，Y，Z，R，R 1，R 2，R 3，R'3 R 4，R 5，R 6，R 7的取代的式（I）的2- [2-（苯基）乙基氨基]烷酰胺衍生物具有本说明书 含有它们作为活性成分的药物组合物及其作为钠和/或钙通道调节剂的用途，其可用于预防，减轻和治愈广泛范围的病理学，包括但不限于神经学，认知功能，精神病学， 炎性，泌尿生殖和胃肠道疾病，其中上述机制被描述为发挥病理作用。

公开(公告)号：US20150157598A1

公开(公告)日：2015-06-11

申请号：US14614677

申请日：2015-02-05

申请人： NEWRON PHARMACEUTICALS S.P.A.

发明人： Piero Melloni ,  Alessandra Restivo ,  Emanuela Izzo ,  Simona Francisconi ,  Elena Colombo ,  Cibele Sabido-David

IPC分类号： A61K31/381 ,  A61K31/137 ,  A61K31/165

CPC分类号： A61K31/381 ,  A61K31/137 ,  A61K31/165 ,  A61K31/40 ,  A61K31/4515 ,  A61K31/519 ,  A61K31/5513 ,  C07C237/06 ,  C07C237/08 ,  C07C237/20 ,  C07C317/28 ,  C07C321/26 ,  C07C323/25 ,  C07C327/42 ,  C07C327/44 ,  C07D207/16 ,  C07D295/182 ,  C07D333/20

摘要： Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives of formula (I) wherein X, Y, Z, R, R1, R2, R3, R′3 R4, R5, R6, R7 have the meanings defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.

公开(公告)号：US09603832B2

公开(公告)日：2017-03-28

申请号：US14615275

申请日：2015-02-05

申请人： NEWRON PHARMACEUTICALS S.P.A.

发明人： Piero Melloni ,  Alessandra Restivo ,  Emanuela Izzo ,  Simona Francisconi ,  Elena Colombo ,  Cibele Sabido-David

IPC分类号： A61K31/165 ,  A61K31/137 ,  A61P5/00 ,  A61P37/00 ,  A61K31/381 ,  C07C237/08 ,  C07C317/28 ,  C07C323/25 ,  C07C327/42 ,  C07D295/182 ,  A61K31/40 ,  A61K31/4515 ,  A61K31/519 ,  A61K31/5513 ,  C07C237/06 ,  C07D207/16 ,  C07D333/20 ,  C07C237/20 ,  C07C321/26 ,  C07C327/44

CPC分类号： A61K31/381 ,  A61K31/137 ,  A61K31/165 ,  A61K31/40 ,  A61K31/4515 ,  A61K31/519 ,  A61K31/5513 ,  C07C237/06 ,  C07C237/08 ,  C07C237/20 ,  C07C317/28 ,  C07C321/26 ,  C07C323/25 ,  C07C327/42 ,  C07C327/44 ,  C07D207/16 ,  C07D295/182 ,  C07D333/20

摘要： Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives of formula (I) wherein X, Y, Z, R, R1, R2, R3, R′3 R4, R5, R6, R7 have the meanings defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.

公开(公告)号：US09585869B2

公开(公告)日：2017-03-07

申请号：US14614677

申请日：2015-02-05

申请人： NEWRON PHARMACEUTICALS S.P.A.

发明人： Piero Melloni ,  Alessandra Restivo ,  Emanuela Izzo ,  Simona Francisconi ,  Elena Colombo ,  Cibele Sabido-David

IPC分类号： A61K31/165 ,  A61K31/137 ,  A61P25/00 ,  A61K31/381 ,  C07C237/08 ,  C07C317/28 ,  C07C323/25 ,  C07C327/42 ,  C07D295/182 ,  A61K31/40 ,  A61K31/4515 ,  A61K31/519 ,  A61K31/5513 ,  C07C237/06 ,  C07D207/16 ,  C07D333/20 ,  C07C237/20 ,  C07C321/26 ,  C07C327/44

CPC分类号： A61K31/381 ,  A61K31/137 ,  A61K31/165 ,  A61K31/40 ,  A61K31/4515 ,  A61K31/519 ,  A61K31/5513 ,  C07C237/06 ,  C07C237/08 ,  C07C237/20 ,  C07C317/28 ,  C07C321/26 ,  C07C323/25 ,  C07C327/42 ,  C07C327/44 ,  C07D207/16 ,  C07D295/182 ,  C07D333/20

摘要： Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives of formula (I) wherein X, Y, Z, R, R1, R2, R3, R′3 R4, R5, R6, R7 have the meanings defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.

摘要翻译： 取代的2- [2-（苯基）乙基氨基]烷酰胺衍生物，其药学上可接受的盐和含有它们的药物组合物可用作用于预防，减轻和治愈其中上述机制发挥病理作用的病症的钠和/或钙通道调节剂。 这些化合物可以特别用于预防，缓解和治愈例如神经，认知，精神，炎症，泌尿生殖和胃肠道疾病。

公开(公告)号：US20150157599A1

公开(公告)日：2015-06-11

申请号：US14614758

申请日：2015-02-05

申请人： NEWRON PHARMACEUTICALS S.P.A.

发明人： Piero Melloni ,  Alessandra Restivo ,  Emanuela Izzo ,  Simona Francisconi ,  Elena Colombo ,  Cibele Sabido-David

IPC分类号： A61K31/381 ,  A61K31/137 ,  A61K31/165

CPC分类号： A61K31/381 ,  A61K31/137 ,  A61K31/165 ,  A61K31/40 ,  A61K31/4515 ,  A61K31/519 ,  A61K31/5513 ,  C07C237/06 ,  C07C237/08 ,  C07C237/20 ,  C07C317/28 ,  C07C321/26 ,  C07C323/25 ,  C07C327/42 ,  C07C327/44 ,  C07D207/16 ,  C07D295/182 ,  C07D333/20

摘要： Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives of formula (I) wherein X, Y, Z, R, R1, R2, R3, R′3 R4, R5, R6, R7 have the meanings defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.

公开(公告)号：US20130274249A1

公开(公告)日：2013-10-17

申请号：US13794555

申请日：2013-03-11

申请人： Newron Pharmaceuticals S.P.A.

发明人： Piero MELLONI ,  Alessandra Restivo ,  Emanuela Izzo ,  Simona Francisconi ,  Elena Colombo ,  Cibele Sabido-David

IPC分类号： A61K31/165 ,  C07D207/16 ,  A61K31/40 ,  A61K31/5513 ,  A61K31/381 ,  A61K31/4515 ,  A61K31/519 ,  C07C237/06 ,  C07D333/20

CPC分类号： A61K31/381 ,  A61K31/137 ,  A61K31/165 ,  A61K31/40 ,  A61K31/4515 ,  A61K31/519 ,  A61K31/5513 ,  C07C237/06 ,  C07C237/08 ,  C07C237/20 ,  C07C317/28 ,  C07C321/26 ,  C07C323/25 ,  C07C327/42 ,  C07C327/44 ,  C07D207/16 ,  C07D295/182 ,  C07D333/20

摘要： Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing them are useful as sodium and/or calcium channel modulators for preventing, alleviating and curing pathologies wherein the above mechanisms play a pathological role. The compounds may be particularly useful for the prevention, alleviation, and curing of, for example, neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases.

摘要翻译： 取代的2- [2-（苯基）乙基氨基]烷酰胺衍生物，其药学上可接受的盐和含有它们的药物组合物可用作用于预防，减轻和治愈其中上述机制发挥病理作用的病症的钠和/或钙通道调节剂。 这些化合物可能特别可用于预防，减轻和治愈例如神经，认知，精神，炎症，泌尿生殖和胃肠道疾病。