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    Therapeutic methods for inhibiting tumor growth with combination of Dll4 antagonists and VEGF antagonists
    8.
    发明授权
    Therapeutic methods for inhibiting tumor growth with combination of Dll4 antagonists and VEGF antagonists 有权
    通过组合Dll4拮抗剂和VEGF拮抗剂抑制肿瘤生长的治疗方法

    公开(公告)号：US08048418B2

    公开(公告)日：2011-11-01

    申请号：US12435030

    申请日：2009-05-04

    申请人： Irene Noguera-Troise ,  Gavin Thurston ,  Nicholas Gale ,  Eric Smith

    发明人： Irene Noguera-Troise ,  Gavin Thurston ,  Nicholas Gale ,  Eric Smith

    IPC分类号： A61K39/395 ,  A61K38/16

    CPC分类号： C07K14/705 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/22 ,  C07K16/28 ,  C07K2317/73 ,  C07K2319/30 ,  C12N2799/022 ,  C12N2799/027

    摘要： Disclosed is a therapeutic method for inhibiting development or growth of tumors that are resistant to the blockade of delta-like ligand 4 (Dll4), or vascular endothelial growth factor (VEGF), or to other therapeutic agents, by administering the combination of Dll4 antagonist and VEGF antagonist. The combined administration of these two agents, concurrently or sequentially, exhibits synergistic effects on blood vessel development and growth, thereby more effectively inhibiting the tumor growth than an administration of either agent alone. The Dll4 antagonist can be an anti-Dll4 antibody or antibody fragment capable of inhibiting the binding of Dll4 to a Notch receptor, or a fusion protein comprising the extracellular domain of Dll4 or a soluble Notch receptor, or a fragment thereof, fused to a multimerizing component. The VEGF antagonist can be a VEGF trap, anti-VEGF antibody or antibody fragment capable of inhibiting the binding of VEGF to a VEGF receptor.

    摘要翻译： 公开了通过施用Dll4拮抗剂的组合来抑制对阻滞δ-样配体4（Dll4）或血管内皮生长因子（VEGF）或其它治疗剂的抗性的肿瘤的发展或生长的治疗方法 和VEGF拮抗剂。 这两种试剂同时或相继地组合施用对血管发育和生长表现出协同作用，从而比单独施用任一试剂更有效地抑制肿瘤生长。 Dll4拮抗剂可以是能够抑制Dll4与Notch受体结合的抗Dll4抗体或抗体片段，或包含融合到多聚化的Dll4的细胞外结构域或其可溶性Notch受体或其片段的融合蛋白 零件。 VEGF拮抗剂可以是能够抑制VEGF与VEGF受体结合的VEGF陷阱，抗VEGF抗体或抗体片段。

    THERAPEUTIC METHODS FOR INHIBITING TUMOR GROWTH WITH DLL4 ANTAGONISTS
    9.
    发明申请
    THERAPEUTIC METHODS FOR INHIBITING TUMOR GROWTH WITH DLL4 ANTAGONISTS 有权
    用DLL4拮抗剂抑制肿瘤生长的治疗方法

    公开(公告)号：US20090246199A1

    公开(公告)日：2009-10-01

    申请号：US12435030

    申请日：2009-05-04

    申请人： Irene Noguera-Troise ,  Gavin Thurston ,  Nicholas Gale ,  Eric Smith

    发明人： Irene Noguera-Troise ,  Gavin Thurston ,  Nicholas Gale ,  Eric Smith

    IPC分类号： A61K39/395 ,  A61K38/16

    CPC分类号： C07K14/705 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/22 ,  C07K16/28 ,  C07K2317/73 ,  C07K2319/30 ,  C12N2799/022 ,  C12N2799/027

    摘要： Disclosed is a therapeutic method for inhibiting development or growth of tumors that are resistant to the blockade of delta-like ligand 4 (Dll4), or vascular endothelial growth factor (VEGF), or to other therapeutic agents, by administering the combination of Dll4 antagonist and VEGF antagonist. The combined administration of these two agents, concurrently or sequentially, exhibits synergistic effects on blood vessel development and growth, thereby more effectively inhibiting the tumor growth than an administration of either agent alone. The Dll4 antagonist can be an anti-Dll4 antibody or antibody fragment capable of inhibiting the binding of Dll4 to a Notch receptor, or a fusion protein comprising the extracellular domain of Dll4 or a soluble Notch receptor, or a fragment thereof, fused to a multimerizing component. The VEGF antagonist can be a VEGF trap, anti-VEGF antibody or antibody fragment capable of inhibiting the binding of VEGF to a VEGF receptor.

    摘要翻译： 公开了通过施用Dll4拮抗剂的组合来抑制对阻滞δ-样配体4（Dll4）或血管内皮生长因子（VEGF）或其它治疗剂的抗性的肿瘤的发展或生长的治疗方法 和VEGF拮抗剂。 这两种试剂同时或相继地组合施用对血管发育和生长表现出协同作用，从而比单独施用任一试剂更有效地抑制肿瘤生长。 Dll4拮抗剂可以是能够抑制Dll4与Notch受体结合的抗Dll4抗体或抗体片段，或包含融合到多聚化的Dll4的细胞外结构域或其可溶性Notch受体或其片段的融合蛋白 零件。 VEGF拮抗剂可以是能够抑制VEGF与VEGF受体结合的VEGF陷阱，抗VEGF抗体或抗体片段。